Question 1

The hematopoietic progenitor cells that eventually repopulate the bone marrow and also circulate in the blood are called:

Accepted Answer

A)  peripheral blood stem cells (PBS
C) . 
B)  hematopoietic stem cells (HS
C) . 
C)  myeloid stem cells (MS
C) . 
D)  lymphoid stem cells. 
A)  peripheral blood stem cells (PBS
C) . 
B)  hematopoietic stem cells (HS
C) . 
C)  myeloid stem cells (MS
C) . 
D)  lymphoid stem cells.

Question 2

One unit of apheresed platelets should increase the platelet count .

Accepted Answer

A)  5,000 to 10,000 per µL 
B)  20,000 to 60,000 per µL 
C)  80,000 to 100,000 per µL 
D)  15,000 to 30,000 per µL 
A)  5,000 to 10,000 per µL 
B)  20,000 to 60,000 per µL 
C)  80,000 to 100,000 per µL 
D)  15,000 to 30,000 per µL

Question 3

Which cell type is densest in the white blood cell layer when anticoagulated blood is centrifuged?

Accepted Answer

A)  Granulocyte 
B)  Monocyte 
C)  Lymphocyte 
D)  Platelets 
A)  Granulocyte 
B)  Monocyte 
C)  Lymphocyte 
D)  Platelets

Question 4

Which of the following incorporates membrane filtration technology with intermittent flow centrifugation (IFC) apheresis?

Accepted Answer

A)  Haemonetics V50 
B)  COBE Spectra 
C)  Fenwal Autopheresis-C 
D)  Haemonetics V30 
A)  Haemonetics V50 
B)  COBE Spectra 
C)  Fenwal Autopheresis-C 
D)  Haemonetics V30

Question 5

What is the primary anticoagulant used in pheresis procedures?

Accepted Answer

A)  CPDA-1 
B)  Heparin 
C)  Citrate 
D)  EDTA 
A)  CPDA-1 
B)  Heparin 
C)  Citrate 
D)  EDTA

Question 6

A donor's estimated total blood volume was determined to be 4,500 mL before a plasmapheresis procedure. The extracorporeal blood volume should not exceed:

Accepted Answer

A)  675 mL. 
B)  335 mL. 
C)  187 mL. 
D)  50 mL. 
A)  675 mL. 
B)  335 mL. 
C)  187 mL. 
D)  50 mL.

Question 7

The removal of red blood cells in a hemapheresis procedure is called:

Accepted Answer

A)  thrombocytapheresis. 
B)  plasmapheresis. 
C)  erythrocytapheresis. 
D)  leukapheresis. 
A)  thrombocytapheresis. 
B)  plasmapheresis. 
C)  erythrocytapheresis. 
D)  leukapheresis.

Question 8

testing is performed on platelet apheresis products to make sure that HIV, WNV, and hepatitis C are not present.

Accepted Answer

A)  Serological 
B)  Nucleic acid 
C)  Electrophoretic 
D)  Rapid 
A)  Serological 
B)  Nucleic acid 
C)  Electrophoretic 
D)  Rapid

Question 9

Leukopheresis may be indicated when the white blood cell count exceeds .

Accepted Answer

A)  50,000 per µL 
B)  100,000 per µL 
C)  75,000 per µL 
D)  25,000 per µL 
A)  50,000 per µL 
B)  100,000 per µL 
C)  75,000 per µL 
D)  25,000 per µL

Question 10

The platelet count of the plateletpheresis donor must be prior to the procedure.

Accepted Answer

A)  >100 $\times$ 109 per L 
B)  >50 $\times$ 109 per L 
C)  >150 $\times$ 109 per L 
D)  >20 $\times$ 109 per L 
A)  >100 $\times$ 109 per L 
B)  >50 $\times$ 109 per L 
C)  >150 $\times$ 109 per L 
D)  >20 $\times$ 109 per L

Question 11

The method in which a specific ligand is bound to an insoluble matrix in a column and plasma is perfused over the column with select removal of pathogenic substance and return of patient's plasma is known as:

Accepted Answer

A)  immunoinhibition. 
B)  plasma exchange. 
C)  immunoadsorption. 
D)  elution. 
A)  immunoinhibition. 
B)  plasma exchange. 
C)  immunoadsorption. 
D)  elution.

Question 12

The concentrate obtained from plateletpheresis via a closed system is stored for 5 days at room temperature. What must the pH be at the end of storage?

Accepted Answer

A)  >=5.0 
B)  >=6.0 
C)  >=4.0 
D)  >=8.0 
A)  >=5.0 
B)  >=6.0 
C)  >=4.0 
D)  >=8.0

Question 13

Plasmapheresis is synonymous with what term?

Accepted Answer

A)  Plasma exchange 
B)  Antibody exchange 
C)  Plasma dilution 
D)  Antibody dilution 
A)  Plasma exchange 
B)  Antibody exchange 
C)  Plasma dilution 
D)  Antibody dilution

Question 14

Antiplatelet medications have differing deferral time periods. Which of the following does not match?

Accepted Answer

A)  Aspirin-48 hours 
B)  Plavix-14 days 
C)  Feldene-7 days 
D)  Ticlid-14 days 
A)  Aspirin-48 hours 
B)  Plavix-14 days 
C)  Feldene-7 days 
D)  Ticlid-14 days

Question 15

Which patients are at the most risk for platelet refractoriness where they become alloimmunized to HLA antigens on platelets?

Accepted Answer

A)  Patients with liver disease 
B)  Cardiac patients 
C)  Leukemic patients 
D)  Kidney transplant patients 
A)  Patients with liver disease 
B)  Cardiac patients 
C)  Leukemic patients 
D)  Kidney transplant patients

Question 16

The removal of endotoxin from patient plasma can be assisted through the use of which adsorbent during plasmapheresis procedures?

Accepted Answer

A)  Cellulose acetate 
B)  Charcoal 
C)  Polymyxin B 
D)  Any of these. 
A)  Cellulose acetate 
B)  Charcoal 
C)  Polymyxin B 
D)  Any of these.

Question 17

What other technique is available for neonates with sepsis when apheresis is unavailable?

Accepted Answer

A)  A buffy coat prepared from plasma less than 12 hours old 
B)  A buffy coat prepared from red blood cells less than 12 hours old 
C)  A buffy coat prepared from a whole blood unit less than 12 hours old 
D)  A buffy coat prepared from platelets less than 12 hours old 
A)  A buffy coat prepared from plasma less than 12 hours old 
B)  A buffy coat prepared from red blood cells less than 12 hours old 
C)  A buffy coat prepared from a whole blood unit less than 12 hours old 
D)  A buffy coat prepared from platelets less than 12 hours old

Question 18

What does the hematocrit need to be (regardless of gender) for a double red blood cell collection?

Accepted Answer

A)  25% 
B)  45% 
C)  40% 
D)  35% 
A)  25% 
B)  45% 
C)  40% 
D)  35%

Question 19

Fresh frozen plasma (FFP) is not the optimal product for replacement fluids for a therapeutic plasma exchange procedure. For which patient is FFP the optimal product of choice?

Accepted Answer

A)  Patient with liver disease 
B)  Patient with thrombotic thrombocytopenic purpura (TTP) 
C)  Patient scheduled to undergo an invasive procedure 
D)  All of the above 
A)  Patient with liver disease 
B)  Patient with thrombotic thrombocytopenic purpura (TTP) 
C)  Patient scheduled to undergo an invasive procedure 
D)  All of the above

Question 20

Which of the following conditions would necessitate a plasmapheresis procedure?

Accepted Answer

A)  Sickle-cell anemia 
B)  Barbiturate poisoning 
C)  CML 
D)  Polycythemia vera 
A)  Sickle-cell anemia 
B)  Barbiturate poisoning 
C)  CML 
D)  Polycythemia vera

Exam 18: Apheresis

The hematopoietic progenitor cells that eventually repopulate the bone marrow and also circulate in the blood are called:

One unit of apheresed platelets should increase the platelet count .

Which cell type is densest in the white blood cell layer when anticoagulated blood is centrifuged?

Which of the following incorporates membrane filtration technology with intermittent flow centrifugation (IFC) apheresis?

What is the primary anticoagulant used in pheresis procedures?

A donor's estimated total blood volume was determined to be 4,500 mL before a plasmapheresis procedure. The extracorporeal blood volume should not exceed:

The removal of red blood cells in a hemapheresis procedure is called:

testing is performed on platelet apheresis products to make sure that HIV, WNV, and hepatitis C are not present.

Leukopheresis may be indicated when the white blood cell count exceeds .

The platelet count of the plateletpheresis donor must be prior to the procedure.

The method in which a specific ligand is bound to an insoluble matrix in a column and plasma is perfused over the column with select removal of pathogenic substance and return of patient's plasma is known as:

The concentrate obtained from plateletpheresis via a closed system is stored for 5 days at room temperature. What must the pH be at the end of storage?

Plasmapheresis is synonymous with what term?

Antiplatelet medications have differing deferral time periods. Which of the following does not match?

Which patients are at the most risk for platelet refractoriness where they become alloimmunized to HLA antigens on platelets?

The removal of endotoxin from patient plasma can be assisted through the use of which adsorbent during plasmapheresis procedures?

What other technique is available for neonates with sepsis when apheresis is unavailable?

What does the hematocrit need to be (regardless of gender) for a double red blood cell collection?

Fresh frozen plasma (FFP) is not the optimal product for replacement fluids for a therapeutic plasma exchange procedure. For which patient is FFP the optimal product of choice?

Which of the following conditions would necessitate a plasmapheresis procedure?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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