Question 1

Which immunoadsorbent has an affinity for IgG classes 1, 2, and 4 and their immune complexes?

Accepted Answer

A)  Charcoal 
B)  Staphylococcal protein A 
C)  DNA 
D)  A antigen 
A)  Charcoal 
B)  Staphylococcal protein A 
C)  DNA 
D)  A antigen

Question 2

Plasma exchange is most effective when is considered the pathological substance.

Accepted Answer

A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE 
A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE

Question 3

All of the following statements are consistent with photopheresis except:

Accepted Answer

A)  the patient is given an oral dose of psoralen, which binds to the DNA of all nucleated cells. 
B)  collected white blood cells are exposed to ultraviolet light, which activates psoralen, preventing replication. 
C)  the patient is given an oral dose of piroxicam, which binds to the RNA of all nucleated cells. 
D)  treated cells are returned to the patient, inducing an immune response against the abnormal lymphocyte clone. 
A)  the patient is given an oral dose of psoralen, which binds to the DNA of all nucleated cells. 
B)  collected white blood cells are exposed to ultraviolet light, which activates psoralen, preventing replication. 
C)  the patient is given an oral dose of piroxicam, which binds to the RNA of all nucleated cells. 
D)  treated cells are returned to the patient, inducing an immune response against the abnormal lymphocyte clone.

Question 4

What can be done to prevent the development of HLA alloimmunization and platelet refractoriness?

Accepted Answer

A)  Test the donor for the presence of platelet antibodies. 
B)  Issue only cytomegalovirus-negative platelets. 
C)  Irradiate the platelet concentrate. 
D)  Reduce the number of leukocytes in the platelet product. 
A)  Test the donor for the presence of platelet antibodies. 
B)  Issue only cytomegalovirus-negative platelets. 
C)  Irradiate the platelet concentrate. 
D)  Reduce the number of leukocytes in the platelet product.

Question 5

When is isolation of PBSCs via apheresis equipment indicated?

Accepted Answer

A)  The bone marrow contains malignant cells 
B)  The bone marrow has been irradiated 
C)  The patient cannot tolerate general anesthesia 
D)  All of the above 
A)  The bone marrow contains malignant cells 
B)  The bone marrow has been irradiated 
C)  The patient cannot tolerate general anesthesia 
D)  All of the above

Question 6

Currently, the immunoaffinity column has FDA licensure for treating what disease state?

Accepted Answer

A)  Hemolytic uremic syndrome 
B)  TTP 
C)  AIDS 
D)  Idiopathic thrombocytopenic purpura (ITP) 
A)  Hemolytic uremic syndrome 
B)  TTP 
C)  AIDS 
D)  Idiopathic thrombocytopenic purpura (ITP)

Question 7

In what circumstance is a plasmapheresis donor rejected from donation?

Accepted Answer

A)  Blood pressure = 140/95 
B)  Temperature = 99.5°F 
C)  Serum protein = 5.0 g/dL 
D)  Hematocrit = 40% 
A)  Blood pressure = 140/95 
B)  Temperature = 99.5°F 
C)  Serum protein = 5.0 g/dL 
D)  Hematocrit = 40%

Question 8

Photopheresis is effective against what malignant disorder?

Accepted Answer

A)  Hairy cell leukemia 
B)  Cutaneous T-cell lymphoma 
C)  Hodgkin's lymphoma 
D)  Acute lymphocytic leukemia 
A)  Hairy cell leukemia 
B)  Cutaneous T-cell lymphoma 
C)  Hodgkin's lymphoma 
D)  Acute lymphocytic leukemia

Question 9

Which of the following statements best describes the apheresis concept?

Accepted Answer

A)  Blood is removed from an individual and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
B)  Blood is removed from an individual, the desired component is retained, anticoagulated, and separated, and the remaining portion is returned to the donor/patient. 
C)  Blood is removed from an individual, anticoagulated, and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
D)  None of the above 
A)  Blood is removed from an individual and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
B)  Blood is removed from an individual, the desired component is retained, anticoagulated, and separated, and the remaining portion is returned to the donor/patient. 
C)  Blood is removed from an individual, anticoagulated, and separated, the desired component is retained, and the remaining portions are returned to the donor/patient. 
D)  None of the above

Question 10

What is the physiological cause of citrate toxicity in cytapheresis procedures?

Accepted Answer

A)  The extracorporeal blood volume leaks citrate into the reinfusion site of the donor. 
B)  The anticoagulant in plasma contains citrate, which binds calcium, lowering the body's ionized calcium. 
C)  The anticoagulant in plasma contains citrate, which binds chloride, lowering the anion gap. 
D)  None of the above. 
A)  The extracorporeal blood volume leaks citrate into the reinfusion site of the donor. 
B)  The anticoagulant in plasma contains citrate, which binds calcium, lowering the body's ionized calcium. 
C)  The anticoagulant in plasma contains citrate, which binds chloride, lowering the anion gap. 
D)  None of the above.

Question 11

When a sample of whole blood is spun, distinct layers form. What cell line or lines make up the buffy coat?

Accepted Answer

A)  White blood cells only 
B)  White blood cells and platelets 
C)  Red blood cells 
D)  Cellular fragments 
A)  White blood cells only 
B)  White blood cells and platelets 
C)  Red blood cells 
D)  Cellular fragments

Question 12

What is the definition of apheresis?

Accepted Answer

A)  The process of freezing RBCs in liquid nitrogen 
B)  Separation or removal of a blood component from whole blood 
C)  The addition of EPO to red blood cells to increase 2,3 DPG levels 
D)  The extraction of plasma from a whole blood unit 
A)  The process of freezing RBCs in liquid nitrogen 
B)  Separation or removal of a blood component from whole blood 
C)  The addition of EPO to red blood cells to increase 2,3 DPG levels 
D)  The extraction of plasma from a whole blood unit

Question 13

What is a disadvantage of choosing fresh frozen plasma for fluid replacement in persons undergoing therapeutic plasmapheresis?

Accepted Answer

A)  Citrate toxicity 
B)  Disease transmission 
C)  ABO incompatibility 
D)  All of the above 
A)  Citrate toxicity 
B)  Disease transmission 
C)  ABO incompatibility 
D)  All of the above

Question 14

What is an example of a continuous flow centrifugation (CFC) instrument?

Accepted Answer

A)  Haemonetics V50 
B)  COBE Spectra 
C)  Fenwal Autopheresis-C 
D)  Haemonetics V30 
A)  Haemonetics V50 
B)  COBE Spectra 
C)  Fenwal Autopheresis-C 
D)  Haemonetics V30

Question 15

A person participating in a serial apheresis program would not:

Accepted Answer

A)  donate more frequently than every 4 weeks. 
B)  lose more than 25 mL of red blood cells per week. 
C)  be monitored for weight loss. 
D)  donate every 72 hours. 
A)  donate more frequently than every 4 weeks. 
B)  lose more than 25 mL of red blood cells per week. 
C)  be monitored for weight loss. 
D)  donate every 72 hours.

Question 16

The specific cell product used for treating sepsis is the:

Accepted Answer

A)  lymphocyte. 
B)  granulocyte. 
C)  monocyte. 
D)  plasmacyte. 
A)  lymphocyte. 
B)  granulocyte. 
C)  monocyte. 
D)  plasmacyte.

Question 17

Which of the following is not an indication for plasmapheresis?

Accepted Answer

A)  To decrease iron deposition in tissues in chronically transfused patients 
B)  To collect rare red blood cell antibodies 
C)  To increase the inventory of AB plasma 
D)  To manufacture Rh-immune globulin 
A)  To decrease iron deposition in tissues in chronically transfused patients 
B)  To collect rare red blood cell antibodies 
C)  To increase the inventory of AB plasma 
D)  To manufacture Rh-immune globulin

Question 18

Compatibility testing is required for granulocyte concentration if the red blood cell contamination is greater than:

Accepted Answer

A)  20 mL. 
B)  10 mL. 
C)  5 mL. 
D)  15 mL. 
A)  20 mL. 
B)  10 mL. 
C)  5 mL. 
D)  15 mL.

Question 19

What variables are necessary to calculate the donor's total blood volume?

Accepted Answer

A)  Height 
B)  Weight 
C)  Sex 
D)  All of the above 
A)  Height 
B)  Weight 
C)  Sex 
D)  All of the above

Question 20

What possible risk exists when hydroxyethyl starch (HES) concentration has exceeded the renal threshold and excretion is retarded?

Accepted Answer

A)  Blockage of the reticuloendothelial system 
B)  Blockage of the spleen 
C)  Citrate toxicity 
D)  Infiltration of the liver by activated macrophages 
A)  Blockage of the reticuloendothelial system 
B)  Blockage of the spleen 
C)  Citrate toxicity 
D)  Infiltration of the liver by activated macrophages

Exam 18: Apheresis

Which immunoadsorbent has an affinity for IgG classes 1, 2, and 4 and their immune complexes?

Plasma exchange is most effective when is considered the pathological substance.

All of the following statements are consistent with photopheresis except:

What can be done to prevent the development of HLA alloimmunization and platelet refractoriness?

When is isolation of PBSCs via apheresis equipment indicated?

Currently, the immunoaffinity column has FDA licensure for treating what disease state?

In what circumstance is a plasmapheresis donor rejected from donation?

Photopheresis is effective against what malignant disorder?

Which of the following statements best describes the apheresis concept?

What is the physiological cause of citrate toxicity in cytapheresis procedures?

When a sample of whole blood is spun, distinct layers form. What cell line or lines make up the buffy coat?

What is the definition of apheresis?

What is a disadvantage of choosing fresh frozen plasma for fluid replacement in persons undergoing therapeutic plasmapheresis?

What is an example of a continuous flow centrifugation (CFC) instrument?

A person participating in a serial apheresis program would not:

The specific cell product used for treating sepsis is the:

Which of the following is not an indication for plasmapheresis?

Compatibility testing is required for granulocyte concentration if the red blood cell contamination is greater than:

What variables are necessary to calculate the donor's total blood volume?

What possible risk exists when hydroxyethyl starch (HES) concentration has exceeded the renal threshold and excretion is retarded?

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The Rh Blood Group System

Blood Group Terminology and Common Blood Groups

Uncommon Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Blood Bank Technologies and Automation

Donor Selection

Transfusion-Transmitted Diseases

Component Preparation

Transfusion Therapy

Adverse Effects of Blood Transfusion

Cellular Therapy in the Transplant Setting

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

Tissue Banking As Part of the Transfusion Service

The Hla System

Relationship Testing

Quality Management

Patient Blood Management

Transfusion Safety and Federal Regulatory Requirements

Laboratory Information Systems in the Blood Bank

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

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