Question 1

Why is thrombocytopenia a manifestation of a massive transfusion?

Accepted Answer

A)  Platelets are diluted by resuscitation fluids and stored blood. 
B)  Platelets are refractory to infused blood. 
C)  Platelets are sequestered in the spleen due to abnormal hemodynamics. 
D)  None of the above 
A)  Platelets are diluted by resuscitation fluids and stored blood. 
B)  Platelets are refractory to infused blood. 
C)  Platelets are sequestered in the spleen due to abnormal hemodynamics. 
D)  None of the above

Question 2

Hemophilia A is clinically apparent when the factor VIII level is less than:

Accepted Answer

A)  20% 
B)  10% 
C)  50% 
D)  60% 
A)  20% 
B)  10% 
C)  50% 
D)  60%

Question 3

The pathological cause of a decreased red blood cell mass include(s):

Accepted Answer

A)  compromised bone marrow production. 
B)  decreased red blood cell survival. 
C)  bleeding as a result of trauma. 
D)  all of the above. 
A)  compromised bone marrow production. 
B)  decreased red blood cell survival. 
C)  bleeding as a result of trauma. 
D)  all of the above.

Question 4

Which of the following should be done when selecting units for a hypoxic neonate?

Accepted Answer

A)  Irradiation 
B)  Cytomegalovirus testing 
C)  Hgb S testing 
D)  Epstein-Barr virus testing 
A)  Irradiation 
B)  Cytomegalovirus testing 
C)  Hgb S testing 
D)  Epstein-Barr virus testing

Question 5

All of the following are characteristics of protein C except:

Accepted Answer

A)  it has a vitamin K dependent factor. 
B)  it has a serine protease inhibitor. 
C)  it enhances factors V and VIII. 
D)  it produces a hypercoagulable state. 
A)  it has a vitamin K dependent factor. 
B)  it has a serine protease inhibitor. 
C)  it enhances factors V and VIII. 
D)  it produces a hypercoagulable state.

Question 6

A 160-pound man was transfused with 1 unit of whole blood after being rescued from a burning apartment building. His hematocrit was determined to be 27% before transfusion. What would you expect his hematocrit to be in 48 hours?

Accepted Answer

A)  28% 
B)  30% 
C)  40% 
D)  45% 
A)  28% 
B)  30% 
C)  40% 
D)  45%

Question 7

What is used to anticoagulate the shed blood obtained from intraoperative salvage?

Accepted Answer

A)  EDTA 
B)  Citrate 
C)  Heparin 
D)  Citrate and heparin 
A)  EDTA 
B)  Citrate 
C)  Heparin 
D)  Citrate and heparin

Question 8

Why is red blood cell transfusion contraindicated in a stable patient with chronic renal failure who has no symptoms except after climbing three flights of stairs?

Accepted Answer

A)  The anemia is compensated. 
B)  The anemia is a "nutritional anemia." 
C)  Whole blood is recommended because the plasma volume is decreased in these patients. 
D)  None of the above 
A)  The anemia is compensated. 
B)  The anemia is a "nutritional anemia." 
C)  Whole blood is recommended because the plasma volume is decreased in these patients. 
D)  None of the above

Question 9

Which of the following is an indication for plasma transfusion in a patient who has been massively transfused?

Accepted Answer

A)  PT = 12 seconds 
B)  PTT greater than 60 seconds 
C)  Fibrinogen = 120 mg/dL 
D)  Platelets = 25,000/µL 
A)  PT = 12 seconds 
B)  PTT greater than 60 seconds 
C)  Fibrinogen = 120 mg/dL 
D)  Platelets = 25,000/µL

Question 10

What is the best-tolerated form of transplantation in humans?

Accepted Answer

A)  Red blood cells 
B)  Platelets 
C)  Bone marrow 
D)  Liver 
A)  Red blood cells 
B)  Platelets 
C)  Bone marrow 
D)  Liver

Question 11

What hemoglobin level is considered critical and may warrant a red blood cell transfusion?

Accepted Answer

A)  10 g/dL 
B)  7 g/dL 
C)  12 g/dL 
D)  9 g/dL 
A)  10 g/dL 
B)  7 g/dL 
C)  12 g/dL 
D)  9 g/dL

Question 12

Which of the following criteria warrants a granulocyte concentrate transfusion?

Accepted Answer

A)  A neutrophil count greater than 1,000 per µL 
B)  A septic patient unresponsive to antibiotics 
C)  Bone marrow hyperplasia 
D)  None of the above 
A)  A neutrophil count greater than 1,000 per µL 
B)  A septic patient unresponsive to antibiotics 
C)  Bone marrow hyperplasia 
D)  None of the above

Question 13

How are RBC aliquots prepared for a neonate transfusion?

Accepted Answer

A)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with saline. 
B)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with glycerol. 
C)  Blood is transferred from collection bag to satellite bag and withdrawn using a syringe. 
D)  None of the above 
A)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with saline. 
B)  Blood is withdrawn from collection bag using a syringe and diluted 1:2 with glycerol. 
C)  Blood is transferred from collection bag to satellite bag and withdrawn using a syringe. 
D)  None of the above

Question 14

Why is plasma not recommended for the treatment of hemophilia B?

Accepted Answer

A)  Hypervolemia limits factor IX efficacy. 
B)  Hypovolemia limits factor IX efficacy. 
C)  Plasma is devoid of factor IX. 
D)  None of the above 
A)  Hypervolemia limits factor IX efficacy. 
B)  Hypovolemia limits factor IX efficacy. 
C)  Plasma is devoid of factor IX. 
D)  None of the above

Question 15

Vitamin K is essential for the carboxylation of which coagulation factors?

Accepted Answer

A)  I, VII, IX, X 
B)  I, V, IX, X 
C)  II, VII, IX, X 
D)  II, VII, XI, XII 
A)  I, VII, IX, X 
B)  I, V, IX, X 
C)  II, VII, IX, X 
D)  II, VII, XI, XII

Question 16

The most important step in the safe administration of blood is to:

Accepted Answer

A)  perform compatibility testing accurately. 
B)  get an accurate patient history. 
C)  exclude disqualified donors. 
D)  accurately identify the donor unit and intended recipient. 
A)  perform compatibility testing accurately. 
B)  get an accurate patient history. 
C)  exclude disqualified donors. 
D)  accurately identify the donor unit and intended recipient.

Question 17

Immunoglobulin prepared from pooled plasma is primarily:

Accepted Answer

A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE 
A)  IgG 
B)  IgM 
C)  IgA 
D)  IgE

Question 18

All of the following are consistent with graft-versus-host disease (GVHD) except:

Accepted Answer

A)  transplantation of immunocompetent T lymphocytes. 
B)  HLA incompatibility between graft and recipient. 
C)  transplantation of "immunologically naive" T lymphocytes. 
D)  an immunocompromised recipient. 
A)  transplantation of immunocompetent T lymphocytes. 
B)  HLA incompatibility between graft and recipient. 
C)  transplantation of "immunologically naive" T lymphocytes. 
D)  an immunocompromised recipient.

Question 19

Cryoprecipitate AHF contains factor VIII. What other coagulation factor is present?

Accepted Answer

A)  I 
B)  V 
C)  VII 
D)  XII 
A)  I 
B)  V 
C)  VII 
D)  XII

Question 20

Deglycerolized red blood cells can be used interchangeably with washed red blood cells, because both procedures:

Accepted Answer

A)  remove white blood cells. 
B)  remove plasma. 
C)  have 24-hour outdate. 
D)  all of the above. 
A)  remove white blood cells. 
B)  remove plasma. 
C)  have 24-hour outdate. 
D)  all of the above.

Exam 15: Transfusion Therapy

Why is thrombocytopenia a manifestation of a massive transfusion?

Hemophilia A is clinically apparent when the factor VIII level is less than:

The pathological cause of a decreased red blood cell mass include(s):

Which of the following should be done when selecting units for a hypoxic neonate?

All of the following are characteristics of protein C except:

A 160-pound man was transfused with 1 unit of whole blood after being rescued from a burning apartment building. His hematocrit was determined to be 27% before transfusion. What would you expect his hematocrit to be in 48 hours?

What is used to anticoagulate the shed blood obtained from intraoperative salvage?

Why is red blood cell transfusion contraindicated in a stable patient with chronic renal failure who has no symptoms except after climbing three flights of stairs?

Which of the following is an indication for plasma transfusion in a patient who has been massively transfused?

What is the best-tolerated form of transplantation in humans?

What hemoglobin level is considered critical and may warrant a red blood cell transfusion?

Which of the following criteria warrants a granulocyte concentrate transfusion?

How are RBC aliquots prepared for a neonate transfusion?

Why is plasma not recommended for the treatment of hemophilia B?

Vitamin K is essential for the carboxylation of which coagulation factors?

The most important step in the safe administration of blood is to:

Immunoglobulin prepared from pooled plasma is primarily:

All of the following are consistent with graft-versus-host disease (GVHD) except:

Cryoprecipitate AHF contains factor VIII. What other coagulation factor is present?

Deglycerolized red blood cells can be used interchangeably with washed red blood cells, because both procedures:

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

Autoimmune Hemolytic Anemias

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

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