Question 1

An oxygen binding curve of fractional saturation versus pO2 displays a sigmoidal shape.This is the oxygen binding curve for

Accepted Answer

A)  myoglobin. 
B)  hemoglobin that has been dissociated into individual subunits. 
C)  hemoglobin in the presence of 2,3-BPG. 
D)  myoglobin in the presence of 2,3-BPG. 
A)  myoglobin. 
B)  hemoglobin that has been dissociated into individual subunits. 
C)  hemoglobin in the presence of 2,3-BPG. 
D)  myoglobin in the presence of 2,3-BPG.

Question 2

If a metabolic enzyme __________ the energy of activation of a reaction,the rate of product formation will __________.

Accepted Answer

A)  increases; decrease 
B)  decreases; increase 
C)  increases; increase 
D)  decreases; decrease 
A)  increases; decrease 
B)  decreases; increase 
C)  increases; increase 
D)  decreases; decrease

Question 3

Consider a system where a passive transport channel is available for a neutral molecule X.If RTln(C2/C1)is zero,then

Accepted Answer

A)  no net transport will occur. 
B)  the molecule will move from the area where the concentration is C2 to the area where the concentration is C1. 
C)  the molecule will move from the area where the concentration is C1 to the area where the concentration is C2. 
D)  There is no way to determine if or how transport of X will occur given the information provided. 
A)  no net transport will occur. 
B)  the molecule will move from the area where the concentration is C2 to the area where the concentration is C1. 
C)  the molecule will move from the area where the concentration is C1 to the area where the concentration is C2. 
D)  There is no way to determine if or how transport of X will occur given the information provided.

Question 4

Which of the following is a pharmaceutical drug that targets an active transporter?

Accepted Answer

A)  sertraline 
B)  malate 
C)  gramicidin A 
D)  2,3-BPG 
A)  sertraline 
B)  malate 
C)  gramicidin A 
D)  2,3-BPG

Question 5

Which of the following pairs are paralogous genes?

Accepted Answer

A)  chicken myoglobin; human  Subunit 
B)  chicken hemoglobin  Subunit; chicken hemoglobin  Subunit 
C)  human hemoglobin  Subunit; chicken hemoglobin  Subunit 
D)  chicken hemoglobin  Subunit; human myoglobin 
A)  chicken myoglobin; human  Subunit 
B)  chicken hemoglobin  Subunit; chicken hemoglobin  Subunit 
C)  human hemoglobin  Subunit; chicken hemoglobin  Subunit 
D)  chicken hemoglobin  Subunit; human myoglobin

Question 6

The estrogen receptor is a(n)

Accepted Answer

A)  G protein-coupled receptor. 
B)  receptor tyrosine kinase. 
C)  nuclear receptor. 
D)  intracellular signaling protein. 
A)  G protein-coupled receptor. 
B)  receptor tyrosine kinase. 
C)  nuclear receptor. 
D)  intracellular signaling protein.

Question 7

Fetal and adult hemoglobin have different affinities for 2,3-BPG.Predict if O2 transport from maternal cells to fetal cells will be altered from the normal rate if the   subunit of the fetal red blood cells have a Ser143   His143 mutation.Include the term T state in your answer.

Accepted Answer

When the fetal @#IMG-DLM&_TB6697_11 subunit contai

Question 8

The lactose permease from E.coli and the molybdate transporter from Archaeoglobus fulgidus both

Accepted Answer

A)  drive transport through the hydrolysis of ATP. 
B)  drive transport through the use of a concentration gradient. 
C)  undergo a conformational change that occurs on substrate binding. 
D)  contain a selectivity filter. 
A)  drive transport through the hydrolysis of ATP. 
B)  drive transport through the use of a concentration gradient. 
C)  undergo a conformational change that occurs on substrate binding. 
D)  contain a selectivity filter.

Question 9

A cell with a membrane potential of -70 mV that contains functioning Na+-K+ ATPase membrane transport proteins will maintain an extracellular __________ concentration that is __________ than the intracellular __________ concentration.

Accepted Answer

A)  Na+; lower; K+ 
B)  Na+; lower; Na+ 
C)  K+; higher; Na+ 
D)  K+; lower; K+ 
A)  Na+; lower; K+ 
B)  Na+; lower; Na+ 
C)  K+; higher; Na+ 
D)  K+; lower; K+

Question 10

Explain how the five arginine residues found within the channel of Omp32 protein of the bacterium Delftia acidovorans increase the specificity of the channel.

Accepted Answer

The arginine residues are negatively cha

Question 11

Consider the movement of glucose into a cell by passive transport.If the extracellular concentration of glucose is 4 mM and the intracellular concentration of glucose is 2 mM,what is the free energy of transport in kJ/mol?

Accepted Answer

The answer of Consider the movement of glucose into a...

Question 12

The translocation rate of a solute across a membrane is measured.A plot of translocation rate versus solute concentration displays a hyperbolic curve.The translation

Accepted Answer

A)  could be occurring through a passive transport channel. 
B)  could be occurring by diffusion. 
C)  could be occurring through a passive transport carrier. 
D)  must require an input of energy. 
A)  could be occurring through a passive transport channel. 
B)  could be occurring by diffusion. 
C)  could be occurring through a passive transport carrier. 
D)  must require an input of energy.

Question 13

Label the structures marked in this diagram of a sarcomere.

Accepted Answer

A is a thi

Question 14

In both myoglobin and hemoglobin,O2 reversibly binds to a(n)__________ atom contained in a porphyrin ring that is tightly bound to the protein.

Accepted Answer

A)  calcium 
B)  iron 
C)  magnesium 
D)  manganese 
A)  calcium 
B)  iron 
C)  magnesium 
D)  manganese

Question 15

A protein displays allosteric regulation.Which of the following is true?

Accepted Answer

A)  Each subunit is either in the T state or the R state, but does not switch from one state to the other. 
B)  Each subunit can exist in more than one conformation. 
C)  When the protein binds to a positive allosteric effector, the subunits are more likely to be in the T state. 
D)  A subunit must be in the R state in order to bind ligand. 
A)  Each subunit is either in the T state or the R state, but does not switch from one state to the other. 
B)  Each subunit can exist in more than one conformation. 
C)  When the protein binds to a positive allosteric effector, the subunits are more likely to be in the T state. 
D)  A subunit must be in the R state in order to bind ligand.

Question 16

Which of the following is NOT considered part of the thin filament?

Accepted Answer

A)  actin 
B)  myosin 
C)  troponin 
D)  tropomyosin 
A)  actin 
B)  myosin 
C)  troponin 
D)  tropomyosin

Question 17

If SERCA is not functioning in a myoblast,which of the following may occur?

Accepted Answer

A)  Myosin will not undergo the conformational change that results in the power stroke. 
B)  Myosin will not be able to bind to the thin filament. 
C)  The myofibrils can shorten but not lengthen. 
D)  The myofibrils can lengthen but not shorten. 
A)  Myosin will not undergo the conformational change that results in the power stroke. 
B)  Myosin will not be able to bind to the thin filament. 
C)  The myofibrils can shorten but not lengthen. 
D)  The myofibrils can lengthen but not shorten.

Question 18

A mutation of the N-terminal valine in adult hemoglobin occurs.The amino acid is replaced with an isoleucine.Studies show that the replacement does not alter the overall structure of the protein.Which of the following hemoglobin functions may be altered?

Accepted Answer

A)  affinity for 2,3-BPG 
B)  ability to transport O2 
C)  ability to transport CO2 
D)  ability to switch from the T state to the R state 
A)  affinity for 2,3-BPG 
B)  ability to transport O2 
C)  ability to transport CO2 
D)  ability to switch from the T state to the R state

Question 19

When ATP binds to myosin,

Accepted Answer

A)  the troponin binding sites are exposed. 
B)  it cannot interact with actin. 
C)  the power stroke occurs. 
D)  the actin nucleotide binding sites are exposed. 
A)  the troponin binding sites are exposed. 
B)  it cannot interact with actin. 
C)  the power stroke occurs. 
D)  the actin nucleotide binding sites are exposed.

Question 20

Using the oxygen binding curve shown,calculate the approximate percentage of O2 that is released from hemoglobin as the pO2 changes from 13 kPa to 4 kPa.

Accepted Answer

A)  4% 
B)  9% 
C)  60% 
D)  91% 
A)  4% 
B)  9% 
C)  60% 
D)  91%

Exam 6: Protein Function

An oxygen binding curve of fractional saturation versus pO2 displays a sigmoidal shape.This is the oxygen binding curve for

If a metabolic enzyme __________ the energy of activation of a reaction,the rate of product formation will __________.

Consider a system where a passive transport channel is available for a neutral molecule X.If RTln(C2/C1)is zero,then

Which of the following is a pharmaceutical drug that targets an active transporter?

Which of the following pairs are paralogous genes?

The estrogen receptor is a(n)

Fetal and adult hemoglobin have different affinities for 2,3-BPG.Predict if O2 transport from maternal cells to fetal cells will be altered from the normal rate if the subunit of the fetal red blood cells have a Ser143 His143 mutation.Include the term T state in your answer.

The lactose permease from E.coli and the molybdate transporter from Archaeoglobus fulgidus both

A cell with a membrane potential of -70 mV that contains functioning Na+-K+ ATPase membrane transport proteins will maintain an extracellular __________ concentration that is __________ than the intracellular __________ concentration.

Explain how the five arginine residues found within the channel of Omp32 protein of the bacterium Delftia acidovorans increase the specificity of the channel.

Consider the movement of glucose into a cell by passive transport.If the extracellular concentration of glucose is 4 mM and the intracellular concentration of glucose is 2 mM,what is the free energy of transport in kJ/mol?

The translocation rate of a solute across a membrane is measured.A plot of translocation rate versus solute concentration displays a hyperbolic curve.The translation

Label the structures marked in this diagram of a sarcomere.

In both myoglobin and hemoglobin,O2 reversibly binds to a(n)__________ atom contained in a porphyrin ring that is tightly bound to the protein.

A protein displays allosteric regulation.Which of the following is true?

Which of the following is NOT considered part of the thin filament?

If SERCA is not functioning in a myoblast,which of the following may occur?

A mutation of the N-terminal valine in adult hemoglobin occurs.The amino acid is replaced with an isoleucine.Studies show that the replacement does not alter the overall structure of the protein.Which of the following hemoglobin functions may be altered?

When ATP binds to myosin,

Using the oxygen binding curve shown,calculate the approximate percentage of O2 that is released from hemoglobin as the pO2 changes from 13 kPa to 4 kPa.

Principles of Biochemistry

Physical Biochemistry: Energy Conversion,water,and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

The Citrate Cycle

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

Dna Replication, repair, and Recombination

Rna Synthesis, processing, and Gene Silencing

Protein Synthesis, posttranslational Modification, and Transport

Gene Regulation

Filters

An oxygen binding curve of fractional saturation versus pO₂ displays a sigmoidal shape.This is the oxygen binding curve for

If a metabolic enzyme the energy of activation of a reaction,the rate of product formation will .

Consider a system where a passive transport channel is available for a neutral molecule X.If RTln(C₂/C₁)is zero,then

Fetal and adult hemoglobin have different affinities for 2,3-BPG.Predict if O₂ transport from maternal cells to fetal cells will be altered from the normal rate if the subunit of the fetal red blood cells have a Ser143 His143 mutation.Include the term T state in your answer.

A cell with a membrane potential of -70 mV that contains functioning Na⁺-K⁺ ATPase membrane transport proteins will maintain an extracellular concentration that is than the intracellular __ concentration.

In both myoglobin and hemoglobin,O₂ reversibly binds to a(n)__________ atom contained in a porphyrin ring that is tightly bound to the protein.

Using the oxygen binding curve shown,calculate the approximate percentage of O₂ that is released from hemoglobin as the pO₂ changes from 13 kPa to 4 kPa.