Exam 8: Cell Signaling Systems

Liver cells were monitored for changes in metabolic enzymatic activity after exposure to glucagon.The enzymes that showed changes in activity were then analyzed to assess if they had been covalently modified.Which of the following results were likely observed?

Which of the following proteins contains an SH3 domain?

On binding of an insulin molecule to the insulin receptor,which region of the receptor becomes phosphorylated?

On binding of insulin to the insulin receptor,the receptor becomes phosphorylated.What is the name of the protein that carried out this phosphorylation?

Glycogen metabolism is regulated when glucagon binds to 2-adrenergic receptors on liver cells.Describe the type of covalent modification that leads to this regulation and distinguish how the modification effects the rate of glycogen synthesis and glycogen degradation.

Which of the following is true of active NF $\kappa$ B?

When bound to GTP, obtains a conformation that promotes interaction with

A mutation causes a cell to divide uncontrollably.Analysis of the cell shows that both copies of the gene must have the mutation.From this information,it can be determined that the mutation is

Which of the following list includes ONLY first messengers?

An estrogen-dependent breast cancer cell line is grown in a medium that contains estrogen.Cell proliferation is monitored over time.In a separate experiment,the cell line is grown in a medium that lacks estrogen but includes bisphenol A,a compound found in polycarbonate plastics.When monitored,cell proliferation is higher than in the presence of estrogen.A possible explanation of these results is that bisphenol A

Below is the molecular structure of a single bovine -arrestin subunit.Two locations are indicated.What is most likely to interact with the protein at these locations?

Caspases contain

When PKA is inactive,which of the following is true?

The __________ is a specific type of __________.

Which class of proteins interacts with a heterotrimeric intracellular protein?

On insulin binding to the insulin receptor,MAP kinase signaling proteins are activated.Which of the following proteins are part of this signaling pathway?

Caspase 3 is responsible for

Nuclear receptors are ligand-activated transcription factors that control a wide range of physiologic responses.The responses are governed by cell-specific expression of nuclear receptors and coregulatory proteins and accessibility of target gene DNA sequences.What else governs the responses?

Which of the following is true of a recessive oncogene mutation but NOT a dominant oncogene mutation?

Phosphorylation of which of the following is necessary for the increased expression of antiapoptotic genes?