Exam 28: Regulation of Gene Expression

How does the transcriptional machinery gain access to the nucleosome-sequestered DNA? I.Methylation of DNA prevents histone binding. II.Chromatin-remodeling complexes allow sections of DNA to be transiently exposed to transcription factors. III.The transcription proteins have higher affinity for DNA and push the histones away from binding sites.

Human cancers are often caused by a mutation in ___, which generally functions to restrain uncontrolled cell proliferation.

Which of the following genes rarely occur in multiple copies? I.histone proteins II.protein-coding genes III.gene clusters

Considering the E.coli trp operon, which of the following is TRUE? I.The formation of the 2-3 hairpin is highly favored over the 1-2 hairpin when trp is low. II.When the concentration of Trp-tRNA^Trp is low, the ribosome halts on tandem Trp codon of segment 1. III.Formation of the 2-3 hairpin facilitates transcription and translation of the trp operon. IV.The attenuator system has no effect when Trp levels are high.

Which of the following are requirements for genetic information? I.Information must be tapped in an orderly fashion. II.Information must be available to direct responses in changes to internal or external conditions. III.Information must be removable following development.

In prokaryotes, which of the following are effective at controlling gene expression relative to the concentration of a metabolite or catabolite? I.CAP or CRP II.long terminal repeats (LTRs) III.riboswitches IV.SWI/SNF

Upstream transcription factors typically contain the following domain(s) I.a DNA binding domain. II.an activation domain, which often is rich in negative charges. III.an ATP binding domain, which is used to promote conformational change in the DNA.

Matching Choose the correct answer from the list. Not all the answers will be used. -In bacteria, riboflavin can inhibit its own synthesis by binding to an mRNA element termed a ______.

Which of the following is TRUE regarding eukaryotic mRNAs? I.They uniformly stable. II.The poly (A)tail appears to partially Moderate the rate of degradation. III.The 5' cap appears to partially Moderate the rate of degradation. IV.They have decay times ranging from 10-30 minutes.

The apparent correlation between histone modification and control over gene expression is termed

Matching Choose the correct answer from the list. Not all the answers will be used. -Enhancer activity can be blocked by the presence of sequences called _____.

Matching Choose the correct answer from the list. Not all the answers will be used. -To induce expression of the lac operon, _______ can be added to the cell medium.

HMG proteins are I.a set of small conserved proteins containing about 50% charged amino acids. II.regulation elements Moderated by the trp attenuation leader sequence. III.able to alter DNA conformation by causing it to bend, unwind, and form loops. IV.architectural proteins that regulate gene expression.

How do steroid hormones influence gene expression?

"Programmed" cell death is called

Matching Choose the correct answer from the list. Not all the answers will be used. -Cell death caused by trauma is called ______.

Which of the following relates to the observation that males and females make approximately equal amounts of X-chromosome gene products?

Which of the following correctly describes the function of the repressor protein controlling expression of the trp operon?

Eukaryotic posttranscriptional control of gene expression does NOT include

RNA interference is a mechanism of posttranscriptional RNA-dependent