Question 1

The diagram represents a "substrate cycle" in glucose metabolism.Which of the following statements about the cycle is true?

Accepted Answer

A) Reactions I & II are catalyzed by the same enzyme and help establish equilibrium between the two metabolites. 
B) Reaction II produces ATP by substrate-level phosphorylation. 
C) Reaction II is catalyzed by an allosteric enzyme that is inhibited by fructose-2-6-bisphosphate. 
D) Reaction I is involved in the biosynthesis of glucose. 
E) Reaction II occurs under low-energy conditions when the cell needs ATP. 
A) Reactions I & II are catalyzed by the same enzyme and help establish equilibrium between the two metabolites. 
B) Reaction II produces ATP by substrate-level phosphorylation. 
C) Reaction II is catalyzed by an allosteric enzyme that is inhibited by fructose-2-6-bisphosphate. 
D) Reaction I is involved in the biosynthesis of glucose. 
E) Reaction II occurs under low-energy conditions when the cell needs ATP.

Question 2

Which statement is true regarding the activation of pyruvate carboxylase by acetyl-CoA?

Accepted Answer

A) Feedback activation enhances flux through glycolysis. 
B) Feedforward activation enhances the entry of pyruvate through the TCA cycle as Acetyl-CoA. 
C) Ensures that gluconeogenesis occurs rather than pyruvate conversion to acetyl-CoA. 
D) Ensures that ATP is not wasted in the production of oxaloacetate. 
E) Feedback inhibition ensures that excess glucose-6-phosphate is not produced. 
A) Feedback activation enhances flux through glycolysis. 
B) Feedforward activation enhances the entry of pyruvate through the TCA cycle as Acetyl-CoA. 
C) Ensures that gluconeogenesis occurs rather than pyruvate conversion to acetyl-CoA. 
D) Ensures that ATP is not wasted in the production of oxaloacetate. 
E) Feedback inhibition ensures that excess glucose-6-phosphate is not produced.

Question 3

Which of the following overall sequences is correct with regard to gluconeogenesis?

Accepted Answer

A) Oxaloacetate $\rarr$ PEP $\rarr$ G6P $\rarr$ Glucose 
B) Pyruvate $\rarr$ FBP $\rarr$ PEP $\rarr$ Glucose 
C) Lactate $\rarr$ PEP $\rarr$ Pyruvate $\rarr$ G6P 
D) Oxaloacetate $\rarr$ F6P $\rarr$ FBP $\rarr$ Glucose 
E) F6P $\rarr$ FBP $\rarr$ Glucose $\rarr$ G6P 
A) Oxaloacetate $\rarr$ PEP $\rarr$ G6P $\rarr$ Glucose 
B) Pyruvate $\rarr$ FBP $\rarr$ PEP $\rarr$ Glucose 
C) Lactate $\rarr$ PEP $\rarr$ Pyruvate $\rarr$ G6P 
D) Oxaloacetate $\rarr$ F6P $\rarr$ FBP $\rarr$ Glucose 
E) F6P $\rarr$ FBP $\rarr$ Glucose $\rarr$ G6P

Question 4

If cAMP levels are high
I.Glycogenolysis will occur in muscle cells but not liver cells.
II.Glucose released from muscle glycogen will enter glycolysis.
III.Glucose released from liver glycogen will exit liver cells via the GLUT4 transporter.
IV.Glucose will enter liver cells resulting in glycogen synthesis.

Accepted Answer

A) I, II, IV 
B) I, II 
C) II, III, IV 
D) II only 
E) III only 
A) I, II, IV 
B) I, II 
C) II, III, IV 
D) II only 
E) III only

Question 5

Matching 
Choose the correct answer from the list. Not all the answers will be used.
-Both glycogen synthesis and glycogen breakdown share the metabolite ______.

Accepted Answer

A) phosphorylase α 
B) gluconeogenesis 
C) glucagon 
D) glucose-6-phosphatase 
E) cAMP
F)biotin
G)insulin
H)glycogenolysis
I)liver
J)glucose-1-phosphate
K)dolichol
L)muscle 
A) phosphorylase α 
B) gluconeogenesis 
C) glucagon 
D) glucose-6-phosphatase 
E) cAMP
F)biotin
G)insulin
H)glycogenolysis
I)liver
J)glucose-1-phosphate
K)dolichol
L)muscle

Question 6

Matching 
Choose the correct answer from the list. Not all the answers will be used.
-Low blood glucose (< 5mM)levels result in the release of ______.

Accepted Answer

A) phosphorylase α 
B) gluconeogenesis 
C) glucagon 
D) glucose-6-phosphatase 
E) cAMP
F)biotin
G)insulin
H)glycogenolysis
I)liver
J)glucose-1-phosphate
K)dolichol
L)muscle 
A) phosphorylase α 
B) gluconeogenesis 
C) glucagon 
D) glucose-6-phosphatase 
E) cAMP
F)biotin
G)insulin
H)glycogenolysis
I)liver
J)glucose-1-phosphate
K)dolichol
L)muscle

Question 7

In glycogen synthesis, the intermediate between glucose-1-phosphate and glycogen is

Accepted Answer

A) UDP-glucose . 
B) UDP-glycogen. 
C) glucose-1,6-bisphosphate. 
D) glucose-6-phosphate. 
E) glucose. 
A) UDP-glucose . 
B) UDP-glycogen. 
C) glucose-1,6-bisphosphate. 
D) glucose-6-phosphate. 
E) glucose.

Question 8

Which of the following statements about glycogen is true?
I.Glycogen is a polymer of glucose in $\alpha$(1$\rarr$6)linkages with $\alpha$(1$\rarr$4)linked branches every 8-14 residues.
II.UDP-glucose is produced from glycogen by the action of the enzyme phosphorylase.
III.In glycogen breakdown, glucose residues are sequentially removed from the nonreducing ends.
IV.The breakdown of glycogen in skeletal muscle ultimately supplies glucose-6-phosphate, which can enter glycolysis to generate ATP.

Accepted Answer

A) I, II, III, IV 
B) I, II 
C) II, III, IV 
D) III, IV 
E) III only 
A) I, II, III, IV 
B) I, II 
C) II, III, IV 
D) III, IV 
E) III only

Question 9

Individuals with McArdle's disease lack the ____ in the ____,

Accepted Answer

A) debranching enzyme; liver 
B) phosphoglucomutase; liver 
C) glycogen phosphorylase; muscle 
D) phosphoglucomutase; muscle 
E) glycogen phosphorylase; liver 
A) debranching enzyme; liver 
B) phosphoglucomutase; liver 
C) glycogen phosphorylase; muscle 
D) phosphoglucomutase; muscle 
E) glycogen phosphorylase; liver

Question 10

Which enzyme has an intermediate of the form presented below?

Accepted Answer

A) phosphofructokinase 
B) glycogen phosphorylase 
C) phosphohexose isomerase 
D) phosphoglucomutase 
E) none of the above 
A) phosphofructokinase 
B) glycogen phosphorylase 
C) phosphohexose isomerase 
D) phosphoglucomutase 
E) none of the above

The diagram represents a "substrate cycle" in glucose metabolism.Which of the following statements about the cycle is true?

Which statement is true regarding the activation of pyruvate carboxylase by acetyl-CoA?

Which of the following overall sequences is correct with regard to gluconeogenesis?

Matching Choose the correct answer from the list. Not all the answers will be used. -Both glycogen synthesis and glycogen breakdown share the metabolite ______.

Matching Choose the correct answer from the list. Not all the answers will be used. -Low blood glucose (< 5mM)levels result in the release of ______.

In glycogen synthesis, the intermediate between glucose-1-phosphate and glycogen is

Individuals with McArdle's disease lack the in the ,

Which enzyme has an intermediate of the form presented below?

Introduction to the Chemistry of Life

Water

Nucleotides, Nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, Inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glucose Catabolism

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

Dna Replication, Repair and Recombination

Transcription and Rna Processing

Translation

Regulation of Gene Expression

Filters

Exam 15: Glycogen Metabolism and Gluconeogenesis

The diagram represents a "substrate cycle" in glucose metabolism.Which of the following statements about the cycle is true?

Which statement is true regarding the activation of pyruvate carboxylase by acetyl-CoA?

Which of the following overall sequences is correct with regard to gluconeogenesis?

Matching Choose the correct answer from the list. Not all the answers will be used. -Both glycogen synthesis and glycogen breakdown share the metabolite ______.

Matching Choose the correct answer from the list. Not all the answers will be used. -Low blood glucose (< 5mM)levels result in the release of ______.

In glycogen synthesis, the intermediate between glucose-1-phosphate and glycogen is

Individuals with McArdle's disease lack the ____ in the ____,

Which enzyme has an intermediate of the form presented below?

Introduction to the Chemistry of Life

Water

Nucleotides, Nucleic Acids, and Genetic Information

Amino Acids

Proteins: Primary Structure

Proteins: Three-Dimensional Structure

Protein Function Part I: Myoglobin and Hemoglobin

Carbohydrates

Lipids and Biological Membranes

Membrane Transport

Enzyme Catalysis

Enzyme Kinetics, Inhibition and Control

Biochemical Signaling

Introduction to Metabolism

Glucose Catabolism

Citric Acid Cycle

Electron Transport and Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Mammalian Fuel Metabolism: Integration and Regulation

Nucleotide Metabolism

Nucleic Acid Structure

Dna Replication, Repair and Recombination

Transcription and Rna Processing

Translation

Regulation of Gene Expression

Filters

Individuals with McArdle's disease lack the in the ,