Question 1

A 10-year-old male with Down syndrome undergoes chemotherapy for cancer. Following treatment, he is most susceptible to:

Accepted Answer

A)  acute lymphoblastic leukemia. 
B)  acute myelogenous leukemia. 
C)  non-Hodgkin lymphoma. 
D)  Hodgkin lymphoma. 
A)  acute lymphoblastic leukemia. 
B)  acute myelogenous leukemia. 
C)  non-Hodgkin lymphoma. 
D)  Hodgkin lymphoma.

Question 2

A 12-year-old male is diagnosed with sickle cell anemia. A blood smear reveals severely sickled cells. The sickled cells will be removed from circulation mostly by the:

Accepted Answer

A)  liver. 
B)  pancreas. 
C)  kidney. 
D)  spleen. 
A)  liver. 
B)  pancreas. 
C)  kidney. 
D)  spleen.

Question 3

A 10-year-old male is diagnosed with sickle cell anemia. He most likely inherited it from:

Accepted Answer

A)  his mother. 
B)  his father. 
C)  both his mother and father. 
D)  none of the above; sickle cell disease is not clearly an inherited disease. 
A)  his mother. 
B)  his father. 
C)  both his mother and father. 
D)  none of the above; sickle cell disease is not clearly an inherited disease.

Question 4

A 5-year-old male is diagnosed with idiopathic thrombocytic purpura (ITP). This condition is caused by:

Accepted Answer

A)  normal postnatal platelet lysis. 
B)  virally induced antibody destruction of platelets. 
C)  an allergic reaction to vaccinations. 
D)  maternal antibodies that target platelets in the neonate. 
A)  normal postnatal platelet lysis. 
B)  virally induced antibody destruction of platelets. 
C)  an allergic reaction to vaccinations. 
D)  maternal antibodies that target platelets in the neonate.

Question 5

A 1-year-old female is diagnosed with anemia secondary to insufficient erythropoiesis. The most likely cause is:

Accepted Answer

A)  genetic factors. 
B)  an iron deficiency. 
C)  a hemoglobin abnormality. 
D)  a erythrocyte structural abnormality. 
A)  genetic factors. 
B)  an iron deficiency. 
C)  a hemoglobin abnormality. 
D)  a erythrocyte structural abnormality.

Question 6

A 25-year-old female has a child that is diagnosed with sickle cell anemia. She does not have the disease. Which of the following characterizes the genetic makeup of the parents with regard to this trait?

Accepted Answer

A)  HbS and HbS 
B)  HbS and HbA 
C)  HbS and HbC 
D)  HbA and HbC 
A)  HbS and HbS 
B)  HbS and HbA 
C)  HbS and HbC 
D)  HbA and HbC

Question 7

Sickle cell disease is characterized by the presence of Hb S. Which of the following amino acids is present in Hb S and not present in normal Hb?

Accepted Answer

A)  Valine 
B)  Glutamic acid 
C)  Proline 
D)  Histidine 
A)  Valine 
B)  Glutamic acid 
C)  Proline 
D)  Histidine

Question 8

The most common childhood cancer is:

Accepted Answer

A)  acute lymphoblastic leukemia. 
B)  chronic myelocytic leukemia. 
C)  non-Hodgkin lymphoma. 
D)  Hodgkin lymphoma. 
A)  acute lymphoblastic leukemia. 
B)  chronic myelocytic leukemia. 
C)  non-Hodgkin lymphoma. 
D)  Hodgkin lymphoma.

Question 9

The mother of a 3-year-old child speaks to the pediatrician because the child took several hours to stop bleeding following a minor scrape. Testing reveals that the child has hemophilia A resulting from a deficiency in:

Accepted Answer

A)  factor IX. 
B)  factor XII. 
C)  factor XIII. 
D)  factor VIII. 
A)  factor IX. 
B)  factor XII. 
C)  factor XIII. 
D)  factor VIII.

Question 10

A 10-year-old female is diagnosed with a malignancy in the brain and lung. DNA analysis reveals translocation at chromosome 7 and 14. The most likely diagnosis is:

Accepted Answer

A)  lymphoblastic non-Hodgkin lymphoma. 
B)  nodular non-Hodgkin lymphoma. 
C)  Hodgkin lymphoma. 
D)  small noncleaved cell non-Hodgkin lymphoma. 
A)  lymphoblastic non-Hodgkin lymphoma. 
B)  nodular non-Hodgkin lymphoma. 
C)  Hodgkin lymphoma. 
D)  small noncleaved cell non-Hodgkin lymphoma.

Question 11

Hemophilia B is also known as:

Accepted Answer

A)  classic hemophilia. 
B)  Christmas disease. 
C)  thalassemia. 
D)  von Willebrand disease. 
A)  classic hemophilia. 
B)  Christmas disease. 
C)  thalassemia. 
D)  von Willebrand disease.

Exam 21: Alterations of Hematologic Function in Children

A 10-year-old male with Down syndrome undergoes chemotherapy for cancer. Following treatment, he is most susceptible to:

A 12-year-old male is diagnosed with sickle cell anemia. A blood smear reveals severely sickled cells. The sickled cells will be removed from circulation mostly by the:

A 10-year-old male is diagnosed with sickle cell anemia. He most likely inherited it from:

A 5-year-old male is diagnosed with idiopathic thrombocytic purpura (ITP). This condition is caused by:

A 1-year-old female is diagnosed with anemia secondary to insufficient erythropoiesis. The most likely cause is:

A 25-year-old female has a child that is diagnosed with sickle cell anemia. She does not have the disease. Which of the following characterizes the genetic makeup of the parents with regard to this trait?

Sickle cell disease is characterized by the presence of Hb S. Which of the following amino acids is present in Hb S and not present in normal Hb?

The most common childhood cancer is:

The mother of a 3-year-old child speaks to the pediatrician because the child took several hours to stop bleeding following a minor scrape. Testing reveals that the child has hemophilia A resulting from a deficiency in:

A 10-year-old female is diagnosed with a malignancy in the brain and lung. DNA analysis reveals translocation at chromosome 7 and 14. The most likely diagnosis is:

Hemophilia B is also known as:

Cellular Biology

Genes and Genetic Diseases

Altered Cellular and Tissue Biology

Fluids and Electrolytes, Acids and Bases

Innate Defenses: Inflammation

Adaptive Immunity

Hypersensitivities, Infection, and Immune Deficiencies

Stress and Disease

Biology of Cancer and Tumor Spread

Cancer Epidemiology, Manifestations, and Treatment

Cancer in Children

Structure and Function of the Neurologic System

Pain, Temperature, Sleep, and Sensory Function

Concepts of Neurologic Dysfunction

Alterations of Neurologic Function

Alterations of Neurologic Function in Children

Mechanisms of Hormonal Regulation

Alterations of Hormonal Regulation

Structure and Function of the Hematologic System

Alterations of Hematologic Function

Structure and Function of the Cardiovascular and Lymphatic Systems

Alterations of Cardiovascular Function

Alterations of Cardiovascular Function in Children

Structure and Function of the Pulmonary System

Alterations of Pulmonary Function

Alterations of Pulmonary Function in Children

Structure and Function of the Renal and Urologic Systems

Alterations of Renal and Urinary Tract Function

Alterations of Renal and Urinary Tract Function in Children

Structure and Function of the Reproductive Systems

Alterations of the Reproductive Systems, Including Sexually Transmitted Infections

Structure and Function of the Digestive System

Alterations of Digestive Function

Alterations of Digestive Function in Children

Structure and Function of the Musculoskeletal System

Alterations of Musculoskeletal Function

Alterations of Musculoskeletal Function in Children

Structure, Function, and Disorders of the Integument

Alterations of the Integument in Children

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