Question 1

Which of the following best describes when a pattern of gene expression is altered without change in the DNA sequence?

Accepted Answer

A)  epigenetic states 
B)  negative autoregulation 
C)  positive autoregulation 
D)  meiosis 
A)  epigenetic states 
B)  negative autoregulation 
C)  positive autoregulation 
D)  meiosis

Question 2

How does entropy drive protein-DNA complex formations?

Accepted Answer

Entropy is often increased by

Question 3

State the four distinct transcription states in the SOS regulon.

Accepted Answer

(1)When the system is in the OFF state,t

Question 4

In yeast,the sugar galactose is converted to what molecule to enter glycolysis?

Accepted Answer

A)  glucose 
B)  fructose 
C)  glucose-6-phosphate 
D)  fructose-6-phosphate 
A)  glucose 
B)  fructose 
C)  glucose-6-phosphate 
D)  fructose-6-phosphate

Question 5

Define the different mechanism of positive and negative gene regulation by ligand binding.

Accepted Answer

As shown in Figure 23.10 a and d,negativ

Question 6

A result of the DNA bend induced by the lac repressor binding is that the __________ groove of the DNA is widened to allow binding of the lac repressor __________.

Accepted Answer

A)  minor;  -helix 
B)  major;  -helix 
C)  minor;  -helix 
D)  major;  -helix 
A)  minor;  -helix 
B)  major;  -helix 
C)  minor;  -helix 
D)  major;  -helix

Question 7

What are the two main types of stem cells?

Accepted Answer

A)  somatic and embryonic 
B)  somatic and epithelial 
C)  stromal and somatic 
D)  stromal and embryonic 
A)  somatic and embryonic 
B)  somatic and epithelial 
C)  stromal and somatic 
D)  stromal and embryonic

Question 8

Describe the three biochemical consequences of histone acetylation.

Accepted Answer

First,it weakens the interaction between

Question 9

The control point for most gene regulation occurs at the initiation of

Accepted Answer

A)  transcription. 
B)  RNA processing. 
C)  protein synthesis. 
D)  protein modifications. 
A)  transcription. 
B)  RNA processing. 
C)  protein synthesis. 
D)  protein modifications.

Question 10

Bicoid,Hunchback,Giant,and Kruppel are all transcription factor proteins involved in __________ pattern.

Accepted Answer

A)  even-skipped expression 
B)  odd-skipped expression 
C)  even-skipped transcription 
D)  odd-skipped transcription 
A)  even-skipped expression 
B)  odd-skipped expression 
C)  even-skipped transcription 
D)  odd-skipped transcription

Question 11

Differentiate among the helix-turn-helix,zinc-finger DNA-binding,leucine zipper,and helix-loop-helix motifs.

Accepted Answer

Helix-turn-helix is approximately 20 ami

Question 12

What are two medical applications that iPS could be used for?

Accepted Answer

A)  type 1 diabetes and Parkinson's 
B)  type 2 diabetes and Parkinson's 
C)  Alzheimer's and Parkinson's 
D)  Alzheimer's and type 2 diabetes 
A)  type 1 diabetes and Parkinson's 
B)  type 2 diabetes and Parkinson's 
C)  Alzheimer's and Parkinson's 
D)  Alzheimer's and type 2 diabetes

Question 13

Together,the eight histone molecules are called the histone

Accepted Answer

A)  octane. 
B)  octamer. 
C)  dimer. 
D)  tetramer. 
A)  octane. 
B)  octamer. 
C)  dimer. 
D)  tetramer.

Question 14

What by-product can be measured for in a cell if lacZ is being used as a reporter gene?

Accepted Answer

A)  luciferase 
B)  chloramphenicol acetyltransferase 
C)    -galactosidase 
D)  GFP 
A)  luciferase 
B)  chloramphenicol acetyltransferase 
C)    -galactosidase 
D)  GFP

Question 15

Which of the following is NOT a common mechanism for modifying transcription factor activity?

Accepted Answer

A)  allosteric activation 
B)  covalent modification 
C)  ionic modification 
D)  positive modulation 
A)  allosteric activation 
B)  covalent modification 
C)  ionic modification 
D)  positive modulation

Question 16

Explain how transcription of the yeast PHO5 gene is regulated.

Accepted Answer

Transcription of the yeast PHO5 gene is

Question 17

How can pluripotency be induced?

Accepted Answer

Reprogramming of differentiated cells to

Question 18

The portion of the histone that can be acetylated is the

Accepted Answer

A)  head. 
B)  body. 
C)  tail. 
D)  arm. 
A)  head. 
B)  body. 
C)  tail. 
D)  arm.

Question 19

Histone acetylation leads to transcriptional activation by

Accepted Answer

A)  increasing the interaction between the histone tail and DNA. 
B)  decreasing the interaction between the histone tail and DNA. 
C)  strengthening the interactions between nucleosomes. 
D)  removing binding sites for additional transcriptional factors. 
A)  increasing the interaction between the histone tail and DNA. 
B)  decreasing the interaction between the histone tail and DNA. 
C)  strengthening the interactions between nucleosomes. 
D)  removing binding sites for additional transcriptional factors.

Question 20

When trp operon is attenuated,what does that mean for the trp operon?

Accepted Answer

A)  inhibition of transcriptional initiation by RNA polymerase 
B)  disruption of transcriptional elongation by RNA polymerase 
C)  initiation by RNA polymerase 
D)  enhancement of transcriptional elongation by RNA polymerase 
A)  inhibition of transcriptional initiation by RNA polymerase 
B)  disruption of transcriptional elongation by RNA polymerase 
C)  initiation by RNA polymerase 
D)  enhancement of transcriptional elongation by RNA polymerase

Exam 23: Gene Regulation

Which of the following best describes when a pattern of gene expression is altered without change in the DNA sequence?

How does entropy drive protein-DNA complex formations?

State the four distinct transcription states in the SOS regulon.

In yeast,the sugar galactose is converted to what molecule to enter glycolysis?

Define the different mechanism of positive and negative gene regulation by ligand binding.

A result of the DNA bend induced by the lac repressor binding is that the __________ groove of the DNA is widened to allow binding of the lac repressor __________.

What are the two main types of stem cells?

Describe the three biochemical consequences of histone acetylation.

The control point for most gene regulation occurs at the initiation of

Bicoid,Hunchback,Giant,and Kruppel are all transcription factor proteins involved in __________ pattern.

Differentiate among the helix-turn-helix,zinc-finger DNA-binding,leucine zipper,and helix-loop-helix motifs.

What are two medical applications that iPS could be used for?

Together,the eight histone molecules are called the histone

What by-product can be measured for in a cell if lacZ is being used as a reporter gene?

Which of the following is NOT a common mechanism for modifying transcription factor activity?

Explain how transcription of the yeast PHO5 gene is regulated.

How can pluripotency be induced?

The portion of the histone that can be acetylated is the

Histone acetylation leads to transcriptional activation by

When trp operon is attenuated,what does that mean for the trp operon?

Principles of Biochemistry

Physical Biochemistry: Energy Conversion,water,and Membranes

Nucleic Acid Structure and Function

Protein Structure

Methods in Protein Biochemistry

Protein Function

Enzyme Mechanisms

Cell Signaling Systems

Glycolysis: a Paradigm of Metabolic Regulation

The Citrate Cycle

Oxidative Phosphorylation

Photosynthesis

Carbohydrate Structure and Function

Carbohydrate Metabolism

Lipid Structure and Function

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Metabolic Integration

Dna Replication, repair, and Recombination

Rna Synthesis, processing, and Gene Silencing

Protein Synthesis, posttranslational Modification, and Transport

Filters

A result of the DNA bend induced by the lac repressor binding is that the groove of the DNA is widened to allow binding of the lac repressor .