Exam 10: Nutritional Genomics

Epigenetics relates not to the genome sequence itself, but to the inherited pattern of gene expression regulated by modifications to DNA.

In addition to the genome sequence, the role of _______________, the microbiome, and modulation of gene expression by dietary factors must also be considered in the overall scope of genome-nutrient interactions.

What initiative was formed to establish a coordinated evidence-based process for evaluating genetic tests and translating genomic applications that are in transition from research to both clinical and public health applications?

Discuss the sex chromosomes.

"Junk DNA" appears to play an important role in:

Like DNA methylation, histone modification is a form of epigenetic regulation.

Discuss the link between genetics and obesity.

Dietary fats interact with various _______________ to influence outcomes.

In addition to advice on specific nutrients and foods, what should the registered dietician tell Mrs. G to avoid or limit in order to lower her risk of this specific polymorphism?

How many pairs of chromosomes comprise the human genome?

The nitrogenous bases include adenine and _______________ (both purines), as well as thymine and _______________.

_______________ determine which patients will benefit or fail to benefit from specific diet prescriptions.

Dietary modification, such as avoidance of phenylalanine, is effective for _______________ diseases, such as PKU.

Cancer can result from genome-wide _______________ due to inappropriate gene activation and chromosomal instability.

The coding strand of DNA that serves as the template for mRNA synthesis is known as the _______________ strand.

What gene mutation is responsible for familial hypercholesterolemia?

When did James Watson and Francis Crick describe the double-helical structure of DNA?

What gender and genotype is most likely to be responsive to dietary and other lifestyle interventions to minimize cardiovascular disease risk?

A diet high in what foods can potentially lower Mrs. G's risk of this genetically linked disease?

Outline the differences between nutrigenetics and nutrigenomics.