Exam 24: HIV and Aids

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Describe the different classes of antiretroviral meds used to combat HIV infection.

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There are currently five classes of antiretroviral medications: 1) Entry inhibitors interfere with the virus's ability to bind to receptors on the outer surface of the cell it tries to enter. When receptor binding fails, HIV cannot infect the cell; 2) Fusion inhibitors interfere with the virus's ability to fuse with a cellular membrane, preventing HIV from entering a cell; 3) Nucleoside/nucleotide reverse transcriptase inhibitors are faulty DNA building blocks. When one of these faulty building blocks is added to a growing HIV DNA chain, no further segments can be added on, halting HIV DNA synthesis. Non-nucleoside reverse transcriptase inhibitors bind to reverse transcriptase, interfering with its ability to convert HIV RNA into HIV DNA; 4) Integrase strand transfer inhibitors block the HIV enzyme integrase, which the virus uses to integrate its genetic material into the DNA of the cell it has infected; and 5) Protease inhibitors interfere with the HIV enzyme called protease, which normally cuts long chains of HIV proteins into smaller individual proteins, thus preventing the assembly of new virus particles.​

In 2010, the FDA approved the daily injectable drug _______________ to treat accumulation of visceral fat around the liver, stomach, and other abdominal organs.

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Egrifta (tesamorelin) ​

Research has shown that _______________ can improve insulin resistance, metabolic abnormalities, and body composition in HIV patients.

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chromium​

Discuss renal problems associated with HIV infection.

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A low level of what nutrient is associated with greater HIV transmission risk between mother and child?​

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What are symptoms of lactic acidosis?​

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According to the World Health Organization, the HIV epidemic has _______________.

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What is the term for a change in a person's antibody status from negative to positive?​

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A CD4 count below what level defines AIDS?​

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What BMI (body mass index) value is associated with increased risk for HIV-related morbidity and mortality?​

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What percentage of weight loss is associated with increased risk for HIV-related morbidity and mortality?​

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What recommendations might the RD suggest regarding NP's diarrhea?​

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Limited evidence supports the use of the glycemic index, fiber, or specific fatty acids in individuals with HIV.

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Combination _______________ testing for both antigen and antibodies allows for earlier diagnosis of HIV infection.

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Because viral load and CD4 counts have been associated with changes in weight, a low viral load or a high CD4 count should be considered a nutritional risk factor.

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AIDS-related wasting is similar to _______________, which is commonly seen in cancer patients.

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Describe testing of genotype and phenotype assays for HIV mutations.

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Describe a nutritional risk screening for a patient with HIV infection.

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If NP's diarrhea cannot be remedied or controlled, what is the primary short-term concern?

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What is a virus called that has not undergone mutations due to the use of antiviral meds?​

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