Preparation of an extract of muscle results in a dramatic decrease in the concentration of citric acid cycle intermediates compared to their concentrations in the tissue. However, in 1935, Szent-Gyorgi showed that the production of CO2 by the extract increased when succinate was added. In fact, for every mole of succinate added, many extra moles of CO2 were produced. Explain this effect in terms of the known catabolic pathways.

The dramatic decrease in the concentrati

Conversion of 1 mol of acetyl-CoA to 2 mol of CO2 and CoA via the citric acid cycle results in the net production of:

A) 1 mol of citrate. B) 1 mol of FADH2. C) 1 mol of NADH. D) 1 mol of oxaloacetate. E) 7 mol of ATP. A) 1 mol of citrate. B) 1 mol of FADH2. C) 1 mol of NADH. D) 1 mol of oxaloacetate. E) 7 mol of ATP.

Exam 16: The Citric Acid Cycle

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The pyruvate dehydrogenase complex and the $\alpha$ -ketoglutarate dehydrogenase complex are homologous enzyme assemblies that require several different coenzymes to carry out their reactions. Which compound does NOT participate directly in the function of these complexes?

(Multiple Choice)

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Question 21

Which reaction of the citric acid cycle produces a net of one water molecule?

(Multiple Choice)

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Question 22

Which statement is NOT true of the citric acid cycle?

(Multiple Choice)

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Question 23

In the citric acid cycle, a five-carbon compound is decarboxylated to yield an activated four-carbon compound. Show the substrate and product in this step, and indicate where any cofactor(s) participate(s).

(Short Answer)

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Question 24

Which statement is FALSE regarding the citric acid cycle?

(Multiple Choice)

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Question 25

Which part of the citric acid cycle from isocitrate to fumarate only are the high-energy phosphate compounds or reduced electron carriers produced or consumed, and name the enzyme that catalyzes each step.

(Essay)

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Question 26

Which statement is FALSE regarding the reaction catalyzed by the $\alpha$ -ketoglutarate dehydrogenase complex?

(Multiple Choice)

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Question 27

The glyoxylate cycle is:

(Multiple Choice)

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Question 28

Which enzyme does NOT have water as a substrate in the reaction it catalyzes?

(Multiple Choice)

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Question 29

Entry of acetyl-CoA into the citric acid cycle is DECREASED when:

(Multiple Choice)

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Question 30

Preparation of an extract of muscle results in a dramatic decrease in the concentration of citric acid cycle intermediates compared to their concentrations in the tissue. However, in 1935, Szent-Gyorgi showed that the production of CO₂ by the extract increased when succinate was added. In fact, for every mole of succinate added, many extra moles of CO₂ were produced. Explain this effect in terms of the known catabolic pathways.

(Essay)

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Question 31

Degradation of leucine yields acetyl-CoA. Can degradation of this amino acid replenish the pool of citric acid cycle intermediates? Explain your reasoning.

(Essay)

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Question 32

Show the three reactions in the citric acid cycle in which NADH is produced, including the structures. None of these reactions involves molecular oxygen (O₂), but all three reactions are strongly inhibited by anaerobic conditions; explain why.

(Essay)

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Question 33

The two moles of CO₂ produced in the first turn of the citric acid cycle have their origin in the:

(Multiple Choice)

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Question 34

Which compound is NOT an intermediate of the citric acid cycle?

(Multiple Choice)

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Question 35

You are in charge of genetically engineering a new bacterium that will derive all of its ATP from sunlight by photosynthesis. Will you put the enzymes of the citric acid cycle in this organism? Briefly explain why or why not.

(Essay)

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Question 36

The citric acid cycle begins with the condensation of acetyl-CoA with oxaloacetate. Describe three possible sources for the acetyl-CoA.

(Essay)

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Question 37

Which compound is NOT required for the oxidative decarboxylation of $\alpha$ -ketoglutarate?

(Multiple Choice)

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Question 38

Conversion of 1 mol of acetyl-CoA to 2 mol of CO₂ and CoA via the citric acid cycle results in the net production of:

(Multiple Choice)

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Question 39

In the citric acid cycle, a flavin coenzyme is required for:

(Multiple Choice)

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Question 40

Showing 21 - 40 of 105

Exam 16: The Citric Acid Cycle

The pyruvate dehydrogenase complex and the α\alphaα -ketoglutarate dehydrogenase complex are homologous enzyme assemblies that require several different coenzymes to carry out their reactions. Which compound does NOT participate directly in the function of these complexes?

Which reaction of the citric acid cycle produces a net of one water molecule?

Which statement is NOT true of the citric acid cycle?

In the citric acid cycle, a five-carbon compound is decarboxylated to yield an activated four-carbon compound. Show the substrate and product in this step, and indicate where any cofactor(s) participate(s).

Which statement is FALSE regarding the citric acid cycle?

Which part of the citric acid cycle from isocitrate to fumarate only are the high-energy phosphate compounds or reduced electron carriers produced or consumed, and name the enzyme that catalyzes each step.

Which statement is FALSE regarding the reaction catalyzed by the α\alphaα -ketoglutarate dehydrogenase complex?

The glyoxylate cycle is:

Which enzyme does NOT have water as a substrate in the reaction it catalyzes?

Entry of acetyl-CoA into the citric acid cycle is DECREASED when:

Degradation of leucine yields acetyl-CoA. Can degradation of this amino acid replenish the pool of citric acid cycle intermediates? Explain your reasoning.

Show the three reactions in the citric acid cycle in which NADH is produced, including the structures. None of these reactions involves molecular oxygen (O2), but all three reactions are strongly inhibited by anaerobic conditions; explain why.

The two moles of CO2 produced in the first turn of the citric acid cycle have their origin in the:

Which compound is NOT an intermediate of the citric acid cycle?

You are in charge of genetically engineering a new bacterium that will derive all of its ATP from sunlight by photosynthesis. Will you put the enzymes of the citric acid cycle in this organism? Briefly explain why or why not.

The citric acid cycle begins with the condensation of acetyl-CoA with oxaloacetate. Describe three possible sources for the acetyl-CoA.

Which compound is NOT required for the oxidative decarboxylation of α\alphaα -ketoglutarate?

Conversion of 1 mol of acetyl-CoA to 2 mol of CO2 and CoA via the citric acid cycle results in the net production of:

In the citric acid cycle, a flavin coenzyme is required for:

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Carbohydrate Biosynthesis in Plants and Bacteria

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The pyruvate dehydrogenase complex and the $\alpha$ -ketoglutarate dehydrogenase complex are homologous enzyme assemblies that require several different coenzymes to carry out their reactions. Which compound does NOT participate directly in the function of these complexes?

Which statement is FALSE regarding the reaction catalyzed by the $\alpha$ -ketoglutarate dehydrogenase complex?

Show the three reactions in the citric acid cycle in which NADH is produced, including the structures. None of these reactions involves molecular oxygen (O₂), but all three reactions are strongly inhibited by anaerobic conditions; explain why.

The two moles of CO₂ produced in the first turn of the citric acid cycle have their origin in the:

Which compound is NOT required for the oxidative decarboxylation of $\alpha$ -ketoglutarate?

Conversion of 1 mol of acetyl-CoA to 2 mol of CO₂ and CoA via the citric acid cycle results in the net production of: