Exam 12: Biosignaling
Match the signal input with the result:
Input
Result
a) Light
1) Sensory cell depolarizes
b) Odorant
2) Sensory cell hyperpolarizes
c) Sweet molecule
3) No effect on sensory cell membrane potential
d) Epinephrine
To match the signal input with the result, we need to understand how different sensory cells respond to various stimuli:a) Light typically causes photoreceptor cells in the retina to hyperpolarize. When light hits these cells, it leads to a chemical change that closes ion channels, causing the cell to become more negative inside compared to the outside.
b) Odorant molecules bind to receptors on olfactory sensory neurons, which usually leads to the depolarization of these cells. This depolarization occurs because the binding of the odorant opens ion channels, allowing positively charged ions to flow into the cell.
c) Sweet molecules interact with taste receptors on the tongue, particularly the G protein-coupled receptors that, when activated, initiate a cascade of events leading to depolarization of the taste sensory cells.
d) Epinephrine (adrenaline) binds to adrenergic receptors on various target cells. Depending on the specific receptor type (alpha or beta receptors), the effect can be either depolarization or hyperpolarization. However, in many cases, epinephrine binding leads to a response that does not directly change the membrane potential but instead triggers a signaling cascade that results in physiological changes, such as increased heart rate or breakdown of glycogen.
Based on this information, the matches would be:
a) Light - 2) Sensory cell hyperpolarizes
b) Odorant - 1) Sensory cell depolarizes
c) Sweet molecule - 1) Sensory cell depolarizes
d) Epinephrine - 3) No effect on sensory cell membrane potential (or it could have various effects depending on the cell type, but for simplicity, we'll choose no direct effect on membrane potential)
Please note that the response to epinephrine can vary greatly depending on the cell type and receptor involved, so the answer provided for epinephrine is a simplified generalization.
Which statement is TRUE of gated ion channels?
A
The specificity of signaling pathways does NOT include:
A
In the insulin-receptor-dependent activation of the protein ERK (extracellular regulated kinase), what protein is responsible for phosphorylating ERK?
Describe three factors that contribute to the high degree of sensitivity of signal transduction systems.
G protein-coupled activation of phospholipase C directly generates which second messenger?
_____ is NOT involved in signal transduction by the -adrenergic receptor pathway.
Which statement does NOT describe a step in the response to photon absorption by rhodopsin?
Which statement concerning signal transduction by the insulin receptor is NOT correct?
Which statement is TRUE regarding the Na+ voltage-gated channel in neurons?
GTP-binding proteins play critical roles in many signal transductions. Describe two cases in which such proteins act, and compare the role of the G proteins in each case.
Briefly compare the two types of guanylyl cyclases that participate in signal transduction.
What is meant by multivalent adaptor proteins in signaling pathways?
The force that drives an ion through a membrane channel depends on the:
The toxins produced by Bordetella pertussis (which causes whooping cough) and by Vibrio cholerae (which causes cholera) have similar modes of action in toxin-sensitive mammalian cells. Describe the molecular basis for their toxic effects.
Mutations are NOT part of the progression from normal to cancerous cells in colorectal cancer in:
Explain why mutations in oncogenes are generally dominant while those in tumor suppressor genes are recessive.
Filters
- Essay(0)
- Multiple Choice(0)
- Short Answer(0)
- True False(0)
- Matching(0)