Question 1

Which drug-induced mechanism does not result in a hemolytic episode?

Accepted Answer

A)  Immune complex formation 
B)  Drug adsorption 
C)  Membrane modification 
D)  Methyldopa-induced autoantibody 
A)  Immune complex formation 
B)  Drug adsorption 
C)  Membrane modification 
D)  Methyldopa-induced autoantibody

Question 2

Which of the following forward-typing reagents may generate false-positive results in a patient with a warm-reacting autoantibody?

Accepted Answer

A)  Anti-A 
B)  Anti-B 
C)  Anti-A, B 
D)  Anti-D 
A)  Anti-A 
B)  Anti-B 
C)  Anti-A, B 
D)  Anti-D

Question 3

A patient with a positive DAT needs to be phenotyped for Jka. What reagent can be used on red blood cells to ensure accurate typing?

Accepted Answer

A)  DTT 
B)  Chloroquine diphosphate 
C)  Ficin 
D)  Digitonin 
A)  DTT 
B)  Chloroquine diphosphate 
C)  Ficin 
D)  Digitonin

Question 4

Anti-K was identified in absorbed serum of a patient with warm autoimmune hemolytic anemia. If a red blood cell phenotype was performed using an indirect antiglobulin test to ensure the patient was negative for K antigen, what would the technologist find?

Accepted Answer

A)  A negative result after cells were treated with ficin 
B)  A positive result due to IgM coating cells 
C)  Patient would type negative for K antigen 
D)  A positive result due to IgG coating cells 
A)  A negative result after cells were treated with ficin 
B)  A positive result due to IgM coating cells 
C)  Patient would type negative for K antigen 
D)  A positive result due to IgG coating cells

Question 5

In cases of warm autoimmune hemolytic anemia, what subclass of IgG is most efficient in binding complement?

Accepted Answer

A)  IgG2 
B)  IgG1 
C)  IgG3 
D)  IgG4 
A)  IgG2 
B)  IgG1 
C)  IgG3 
D)  IgG4

Question 6

A benign cold autoagglutinin may cause interference in antibody screening procedures when:

Accepted Answer

A)  anti-IgG AHG reagents are used in the test procedure. 
B)  polyspecific AHG reagents are used in the test procedure. 
C)  the immediate spin phase is omitted. 
D)  LISS is used as a potentiator at 37°C incubation. 
A)  anti-IgG AHG reagents are used in the test procedure. 
B)  polyspecific AHG reagents are used in the test procedure. 
C)  the immediate spin phase is omitted. 
D)  LISS is used as a potentiator at 37°C incubation.

Which drug-induced mechanism does not result in a hemolytic episode?

Which of the following forward-typing reagents may generate false-positive results in a patient with a warm-reacting autoantibody?

A patient with a positive DAT needs to be phenotyped for Jk^a. What reagent can be used on red blood cells to ensure accurate typing?

Anti-K was identified in absorbed serum of a patient with warm autoimmune hemolytic anemia. If a red blood cell phenotype was performed using an indirect antiglobulin test to ensure the patient was negative for K antigen, what would the technologist find?

In cases of warm autoimmune hemolytic anemia, what subclass of IgG is most efficient in binding complement?

A benign cold autoagglutinin may cause interference in antibody screening procedures when:

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

Exam 20: Autoimmune Hemolytic Anemias

Which drug-induced mechanism does not result in a hemolytic episode?

Which of the following forward-typing reagents may generate false-positive results in a patient with a warm-reacting autoantibody?

A patient with a positive DAT needs to be phenotyped for Jka. What reagent can be used on red blood cells to ensure accurate typing?

Anti-K was identified in absorbed serum of a patient with warm autoimmune hemolytic anemia. If a red blood cell phenotype was performed using an indirect antiglobulin test to ensure the patient was negative for K antigen, what would the technologist find?

In cases of warm autoimmune hemolytic anemia, what subclass of IgG is most efficient in binding complement?

A benign cold autoagglutinin may cause interference in antibody screening procedures when:

Red Blood Cells and Platelet Preservation: Historical Perspectives and Current Trends

Basic Genetics

Fundamentals of Immunology

Concepts in Molecular Biology

The Antiglobulin Test

The Abo Blood Group System

The RH Blood Group System

Blood Group Terminology and the Other Blood Groups

Detection and Identification of Antibodies

Pre-Transfusion Testing

Overview of the Routine Blood Bank Laboratory

Other Technologies and Automation

Donor Screening and Component Preparation

Apheresis

Transfusion Therapy

Cellular Therapy

Transfusion-Transmitted Diseases

Hemolytic Disease of the Fetus and Newborn

The Hla System

Relationship Testing

Quality Management

Transfusion Safety and Federal Regulatory Requirements

Utilization Management

Laboratory Information Systems

Medicolegal and Ethical Aspects of Providing Blood Collection and Transfusion Services

Tissue Banking: A New Role for the Transfusion Service

Filters

A patient with a positive DAT needs to be phenotyped for Jk^a. What reagent can be used on red blood cells to ensure accurate typing?