Question 1

Which of the following is a lipid-soluble electron carrier in its reduced state?

Accepted Answer

A)  NADPH 
B)  NADH 
C)  NAD+ 
D)  ubiquinol 
E)  ubiquinone 
A)  NADPH 
B)  NADH 
C)  NAD+ 
D)  ubiquinol 
E)  ubiquinone

Question 2

Which of the following factors contributes to the highly exergonic nature of ATP hydrolysis?

Accepted Answer

A)  removal of phosphate from the cytoplasm 
B)  addition of water to the hydrophilic ATP molecule 
C)  decrease in negative-ion repulsion in ATP 
D)  low energy of activation for the hydrolysis 
E)  none of the above 
A)  removal of phosphate from the cytoplasm 
B)  addition of water to the hydrophilic ATP molecule 
C)  decrease in negative-ion repulsion in ATP 
D)  low energy of activation for the hydrolysis 
E)  none of the above

Question 3

The oxidized form of NADH is _____.

Accepted Answer

A)  NADH+ 
B)  NAD+ 
C)  NADH 
D)  NADH2 
E)  none of the above 
A)  NADH+ 
B)  NAD+ 
C)  NADH 
D)  NADH2 
E)  none of the above

Question 4

For the following reaction, calculate the $\Delta$G at 37°C, given concentrations for glucose-1-phosphate of 25 mM and glucose-6-phosphate of 1 mM.
Glucose-1-phosphate   glucose-6-phosphate $\Delta$G°    = -7.1 kJ/mol

Accepted Answer

A)  -15.4 kJ/mol 
B)  -8.1 kJ/mol 
C)  -6.1 kJ/mol 
D)  1.2 kJ/mol 
E)  none of the above 
A)  -15.4 kJ/mol 
B)  -8.1 kJ/mol 
C)  -6.1 kJ/mol 
D)  1.2 kJ/mol 
E)  none of the above

Question 5

Amino acids can be converted to _____.

Accepted Answer

A)  carbohydrates 
B)  fatty acids 
C)  nucleotides 
D)  peptides 
E)  all of the above 
A)  carbohydrates 
B)  fatty acids 
C)  nucleotides 
D)  peptides 
E)  all of the above

Question 6

Metabolomics is the study of the metabolic activity of a cell or tissue by identifying and quantifying all of its metabolites.

Accepted Answer

A) True 
 B)False

Question 7

For the following reaction, calculate the Keq at 25°C.
Succinyl-CoA + acetoacetate   acetoacetyl-CoA + succinate $\Delta$G°   = -1.25 kJ/mol

Accepted Answer

A)  0.602 
B)  1.00 
C)  1.66 
D)  3.21 
E)  4.22c*c 102 
A)  0.602 
B)  1.00 
C)  1.66 
D)  3.21 
E)  4.22c*c 102

Question 8

Which of the following is mobilized for energy use by a phosphorolysis reaction, not a hydrolysis?

Accepted Answer

A)  glycogen 
B)  protein 
C)  triacylglycerols 
D)  polynucleotides 
E)  cholesterol esters 
A)  glycogen 
B)  protein 
C)  triacylglycerols 
D)  polynucleotides 
E)  cholesterol esters

Question 9

Which of the following molecules is in the most reduced state?

Accepted Answer

A)  methane 
B)  formaldehyde 
C)  formic acid 
D)  methanol 
E)  carbon dioxide 
A)  methane 
B)  formaldehyde 
C)  formic acid 
D)  methanol 
E)  carbon dioxide

Question 10

For the following reaction, calculate the $\Delta$G°  at 37°C.
Glucose-6-phosphate   fructose-6-phosphate Keq = 0.517

Accepted Answer

A)  -2.87 kJ/mol 
B)  -1.70 kJ/mol 
C)  0.203 kJ/mol 
D)  -0.738 kJ/mol 
E)  1.70 kJ/mol 
A)  -2.87 kJ/mol 
B)  -1.70 kJ/mol 
C)  0.203 kJ/mol 
D)  -0.738 kJ/mol 
E)  1.70 kJ/mol

Question 11

Eukaryotes evolved and developed extensive intracellular membraines enclosed in compartments called _______.

Accepted Answer

A)  lysosomes 
B)  organelles 
C)  peroxisomes 
D)  vacuoles 
A)  lysosomes 
B)  organelles 
C)  peroxisomes 
D)  vacuoles

Question 12

If the following reactions were coupled, what would be the overall $\Delta$G°   $\rightarrow$
Glucose + Pi   glucose-6-phosphate $\Delta$G°    = 13.8 kJ/mol
ATP + H2O   ADP + Pi $\Delta$G°    = -30.5 kJ/mol

Accepted Answer

A)  44.3 kJ/mol 
B)  16.7 kJ/mol 
C)  0 kJ/mol 
D)  -16.7 kJ/mol 
E)  -44.3 kJ/mol 
A)  44.3 kJ/mol 
B)  16.7 kJ/mol 
C)  0 kJ/mol 
D)  -16.7 kJ/mol 
E)  -44.3 kJ/mol

Question 13

Which of the following is correct regarding metabolic pathways?

Accepted Answer

A)  most pathways are isolated from other pathways 
B)  the activity of most pathways is not regulated 
C)  all cells within a multi-cellular organism contain the same pathways 
D)  anabolic pathways never occur at the same time as catabolic pathways 
E)  none of the above are correct 
A)  most pathways are isolated from other pathways 
B)  the activity of most pathways is not regulated 
C)  all cells within a multi-cellular organism contain the same pathways 
D)  anabolic pathways never occur at the same time as catabolic pathways 
E)  none of the above are correct

Question 14

Which of the following describes the bonding of the three phosphates to adenosine in ATP? How many phosphoanhydride bonds are found in ATP?

Accepted Answer

A)  one phosphoanhydride bond, two low energy phosphate esters 
B)  two phosphoanhydride bonds, one low energy phosphate ester 
C)  three phosphoanhydride bonds, one low energy phosphate ester 
D)  three phosphoanhydride bonds 
E)  none of the above 
A)  one phosphoanhydride bond, two low energy phosphate esters 
B)  two phosphoanhydride bonds, one low energy phosphate ester 
C)  three phosphoanhydride bonds, one low energy phosphate ester 
D)  three phosphoanhydride bonds 
E)  none of the above

Question 15

Acetylcholinesterase catalyzes the reaction in which acetylcholine is hydrolyzed into acetate and choline. This is a reversible reaction. A student incubates a 1 M solution of acetylcholine for two hours with 100uL of acetylcholinesterase. At equilibrium the concentration of acetylcholine is 3.0 × 10 mM and the concentration of acetate and choline are 5.2 × 10-3 M and 7.4 x 10-2 M, respectively.
Calculate the equilibrium constant (Keq) and the standard state free energy ($\Delta$G°') for this reaction at 17°C.

Accepted Answer

The equilibrium constant K_eq

Question 16

The $\Delta$G°    for the hydrolysis of acetyl CoA is most similar to the $\Delta$G°   for the hydrolysis of _____.

Accepted Answer

A)  1,3-bisphosphoglycerate 
B)  ATP 
C)  glucose-1-phosphate 
D)  glucose-6-phosphate 
E)  phosphoenolpyruvate 
A)  1,3-bisphosphoglycerate 
B)  ATP 
C)  glucose-1-phosphate 
D)  glucose-6-phosphate 
E)  phosphoenolpyruvate

Question 17

The reaction below is an example of _________________.

Accepted Answer

A)  dehydration 
B)  hydration 
C)  oxidation 
D)  reduction 
E)  none of the above 
A)  dehydration 
B)  hydration 
C)  oxidation 
D)  reduction 
E)  none of the above

Question 18

Degradation of proteins within a cell can occur within the _____ or by use of _____.

Accepted Answer

A)  endoplasmic reticulum; protease enzymes chymotrypsin and trypsin 
B)  Golgi apparatus; protease enzymes chymotrypsin and trypsin 
C)  endoplasmic reticulum; a proteasome 
D)  lysosome; a proteasome 
E)  mitochondria; ubiquitin 
A)  endoplasmic reticulum; protease enzymes chymotrypsin and trypsin 
B)  Golgi apparatus; protease enzymes chymotrypsin and trypsin 
C)  endoplasmic reticulum; a proteasome 
D)  lysosome; a proteasome 
E)  mitochondria; ubiquitin

Question 19

Which of the following has the most spontaneous hydrolysis?

Accepted Answer

A)  1,3-bisphosphoglycerate 
B)  phosphocreatine 
C)  glucose-1-phosphate 
D)  pyrophosphate 
E)  phosphoenolpyruvate 
A)  1,3-bisphosphoglycerate 
B)  phosphocreatine 
C)  glucose-1-phosphate 
D)  pyrophosphate 
E)  phosphoenolpyruvate

Question 20

Which of the following molecules is involved with the oxidation of glucose, synthesis of fatty acids and oxidation of fatty acids?

Accepted Answer

A)  pyruvate 
B)  acetyl-CoA 
C)  alanine 
D)  oxaloacetate 
E)  glyceraldehyde-3-phosphate 
A)  pyruvate 
B)  acetyl-CoA 
C)  alanine 
D)  oxaloacetate 
E)  glyceraldehyde-3-phosphate

Which of the following is a lipid-soluble electron carrier in its reduced state?

Which of the following factors contributes to the highly exergonic nature of ATP hydrolysis?

The oxidized form of NADH is _____.

Amino acids can be converted to _____.

Metabolomics is the study of the metabolic activity of a cell or tissue by identifying and quantifying all of its metabolites.

Which of the following is mobilized for energy use by a phosphorolysis reaction, not a hydrolysis?

Which of the following molecules is in the most reduced state?

For the following reaction, calculate the $\Delta$ G° at 37°C. Glucose-6-phosphate $For the following reaction, calculate the \Delta G° at 37°C. Glucose-6-phosphate fructose-6-phosphate K<sub>eq</sub> = 0.517$ fructose-6-phosphate K_eq = 0.517

Eukaryotes evolved and developed extensive intracellular membraines enclosed in compartments called _______.

Which of the following is correct regarding metabolic pathways?

Which of the following describes the bonding of the three phosphates to adenosine in ATP? How many phosphoanhydride bonds are found in ATP?

The $\Delta$ G° $The \Delta G° for the hydrolysis of acetyl CoA is most similar to the \Delta G° for the hydrolysis of _____.$ for the hydrolysis of acetyl CoA is most similar to the $\Delta$ G° 11ee7c69_05ae_405c_ae82_f7bc848d8fc6_TBW1044_11 for the hydrolysis of _____.

The reaction below is an example of _________________.

Degradation of proteins within a cell can occur within the _ or by use of _.

Which of the following has the most spontaneous hydrolysis?

Which of the following molecules is involved with the oxidation of glucose, synthesis of fatty acids and oxidation of fatty acids?

The Chemical Basis of Life

Aqueous Chemistry

Nucleic Acid Structure and Function

Protein Structure

Protein Function

How Enzymes Work

Enzyme Kinetics and Inhibition

Lipids and Membranes

Membrane Transport

Signaling

Carbohydrates

Glucose Metabolism

The Citric Acid Cycle

Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Nitrogen Metabolism

Regulation of Mammalian Fuel Metabolism

DNA Replication and Repair

Transcription and RNA

Protein Synthesis

Filters

Exam 12: Metabolism and Bioenergetics

Which of the following is a lipid-soluble electron carrier in its reduced state?

Which of the following factors contributes to the highly exergonic nature of ATP hydrolysis?

The oxidized form of NADH is _____.

For the following reaction, calculate the Δ\DeltaΔ G at 37°C, given concentrations for glucose-1-phosphate of 25 mM and glucose-6-phosphate of 1 mM. Glucose-1-phosphate glucose-6-phosphate Δ\DeltaΔ G° = -7.1 kJ/mol

Amino acids can be converted to _____.

Metabolomics is the study of the metabolic activity of a cell or tissue by identifying and quantifying all of its metabolites.

For the following reaction, calculate the Keq at 25°C. Succinyl-CoA + acetoacetate acetoacetyl-CoA + succinate Δ\DeltaΔ G° = -1.25 kJ/mol

Which of the following is mobilized for energy use by a phosphorolysis reaction, not a hydrolysis?

Which of the following molecules is in the most reduced state?

For the following reaction, calculate the Δ\DeltaΔ G° at 37°C. Glucose-6-phosphate fructose-6-phosphate Keq = 0.517

Eukaryotes evolved and developed extensive intracellular membraines enclosed in compartments called _______.

Which of the following is correct regarding metabolic pathways?

Which of the following describes the bonding of the three phosphates to adenosine in ATP? How many phosphoanhydride bonds are found in ATP?

The Δ\DeltaΔ G° for the hydrolysis of acetyl CoA is most similar to the Δ\DeltaΔ G° 11ee7c69_05ae_405c_ae82_f7bc848d8fc6_TBW1044_11 for the hydrolysis of _____.

The reaction below is an example of _________________.

Degradation of proteins within a cell can occur within the _____ or by use of _____.

Which of the following has the most spontaneous hydrolysis?

Which of the following molecules is involved with the oxidation of glucose, synthesis of fatty acids and oxidation of fatty acids?

The Chemical Basis of Life

Aqueous Chemistry

Nucleic Acid Structure and Function

Protein Structure

Protein Function

How Enzymes Work

Enzyme Kinetics and Inhibition

Lipids and Membranes

Membrane Transport

Signaling

Carbohydrates

Glucose Metabolism

The Citric Acid Cycle

Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Nitrogen Metabolism

Regulation of Mammalian Fuel Metabolism

DNA Replication and Repair

Transcription and RNA

Protein Synthesis

Filters

For the following reaction, calculate the $\Delta$ G° at 37°C. Glucose-6-phosphate $For the following reaction, calculate the \Delta G° at 37°C. Glucose-6-phosphate fructose-6-phosphate K<sub>eq</sub> = 0.517$ fructose-6-phosphate K_eq = 0.517

The $\Delta$ G° $The \Delta G° for the hydrolysis of acetyl CoA is most similar to the \Delta G° for the hydrolysis of _____.$ for the hydrolysis of acetyl CoA is most similar to the $\Delta$ G° 11ee7c69_05ae_405c_ae82_f7bc848d8fc6_TBW1044_11 for the hydrolysis of _____.

Degradation of proteins within a cell can occur within the _ or by use of _.