Exam 6: How Enzymes Work

Which of the following is true regarding heparin?

Which of the following is a feature of protease inhibitor specific for trypsin?

Different enzymes that catalyze the same reaction are known as _____.

In an enzyme mechanism that generates a negative charge in the transition state, which of the following would be most effective to have in the active site of the enzyme?

An organic molecule that is tightly bound to an enzyme and participates in an enzyme catalyzed reaction is specifically referred to as a _____.

Zymogens are not enzymatically active because _____.

Thrombin is similar to ___ as it cleaves peptide bonds following ___ residues.

In the enzyme catalyzed decarboxylation of acetoacetate, a Schiff base is formed between the ketone of acetoacetate and a _____ residue in the active site of the enzyme.

If an enzyme rate increases 10-fold for every 5.7 kJ/mol decrease in the energy of activation, what rate increase would be observed if three H-bonds were stabilizing the transition state with each H-bond having a strength of 21 kJ/mol?

Of the following ions, which would be most likely to participate in metal ion catalysis?

Of all the species that enzymes bind, they are thought to bind most tightly to _____.

The ability for an enzyme to pick out one particular substrate from the myriad of molecules floating around its environment is an example of _____.

The enzyme hexokinase catalyzes a reaction where its substrates are completely sequestered from the aqueous environment allowing for interactions to occur between enzyme and substrates that would not normally occur in an aqueous environment. What term describes this type of catalysis?

The blood coagulation cascade is triggered when ___ is converted to ___.

How does a catalyst increase the rate of a reaction?

How does a catalyst increase the rate of a reaction?

Thrombin circulates in the blood as a(n) ___ that is called ___.

Fibrinogen is converted to _____ by the action of _____.

Which protein in the blood is responsible for converting fibrinogen to fibrin?

Conversion of factor X to factor Xa represents a(n) _____ form of activation; binding of antithrombin to thrombin represents a(n) _____ form of inhibition.