Question 1

The ability for some receptor tyrosine kinases to ultimately activate phospholipase C is an example of _____.

Accepted Answer

A)  antagonism 
B)  desensitization 
C)  autophosphorylation 
D)  poor receptor-ligand specificity 
E)  cross-talk 
A)  antagonism 
B)  desensitization 
C)  autophosphorylation 
D)  poor receptor-ligand specificity 
E)  cross-talk E

Question 2

A sample of cells with a total receptor concentration of 50  $\mu$ M was incubated with a ligand concentration of 100  $\mu$ M. Following the incubation period, the concentration of unbound receptors was determined to be 15  $\mu$ M. What is the Kd for the receptor-ligand interaction?

Accepted Answer

A)  28  $\mu$ M 
B)  43  $\mu$ M 
C)  143  $\mu$ M 
D)  217  $\mu$ M 
E)  333  $\mu$ M 
A)  28  $\mu$ M 
B)  43  $\mu$ M 
C)  143  $\mu$ M 
D)  217  $\mu$ M 
E)  333  $\mu$ M A

Question 3

The eicosanoids are derived from the membrane fatty acid _____.

Accepted Answer

A)  stearic acid 
B)  linoleic acid 
C)   $\alpha$ -linolenic acid 
D)  arachidonic acid 
E)  docosahexaenoic acid (DH
A)  
A)  stearic acid 
B)  linoleic acid 
C)   $\alpha$ -linolenic acid 
D)  arachidonic acid 
E)  docosahexaenoic acid (DH
A)  D

Question 4

The _____ signaling pathway undergoes autophosphorylation, resulting in kinase activation.

Accepted Answer

receptor t

Question 5

The complex formed between a lipid hormone and its receptor binds to _____ which are specific DNA sequences.

Accepted Answer

A)  transcription factors 
B)  nuclear localization sequences 
C)  DNA-binding domains 
D)  hormone response elements 
E)  none of the above 
A)  transcription factors 
B)  nuclear localization sequences 
C)  DNA-binding domains 
D)  hormone response elements 
E)  none of the above

Question 6

Which of the following can be a hormone?

Accepted Answer

A)  amino acid derivatives 
B)  steroids 
C)  polypeptides 
D)  eicosanoids 
E)  all of the above 
A)  amino acid derivatives 
B)  steroids 
C)  polypeptides 
D)  eicosanoids 
E)  all of the above

Question 7

Which of the following hormones is able to cross biological membranes and thus the receptor is found inside the cell, not on the cell surface?

Accepted Answer

A)  insulin 
B)  glucagon 
C)  cortisol 
D)  epinephrine 
E)  platelet derived growth factor 
A)  insulin 
B)  glucagon 
C)  cortisol 
D)  epinephrine 
E)  platelet derived growth factor

Question 8

Interaction of the Ras protein with ___ results in activation by ___

Accepted Answer

an adaptor

Question 9

Hormones bind to _____ with _____ affinity.

Accepted Answer

A)  ligands; low 
B)  agonists; high 
C)  antagonists; low 
D)  G proteins; low 
E)  receptors; high 
A)  ligands; low 
B)  agonists; high 
C)  antagonists; low 
D)  G proteins; low 
E)  receptors; high

Question 10

When a receptor loses its ability to transmit a signal following continuous exposure to a ligand, the receptor is said to be _____.

Accepted Answer

A)  saturated 
B)  desensitized 
C)  transduced 
D)  specific 
E)  none of the above 
A)  saturated 
B)  desensitized 
C)  transduced 
D)  specific 
E)  none of the above

Question 11

Activity of the Ras protein is analogous to the _____ in terms of its ability to bind GTP.

Accepted Answer

A)  G protein  $\alpha$  subunit 
B)  G protein  $\beta$  subunit 
C)  G protein  $\gamma$  subunit 
D)  calmodulin 
E)  all of the above 
A)  G protein  $\alpha$  subunit 
B)  G protein  $\beta$  subunit 
C)  G protein  $\gamma$  subunit 
D)  calmodulin 
E)  all of the above

Question 12

Which of the following is an inhibitor of cyclooxygenase?

Accepted Answer

A)  acetaminophen 
B)  aspirin 
C)  eicosanoic acid 
D)  thromboxane 
E)  progesterone 
A)  acetaminophen 
B)  aspirin 
C)  eicosanoic acid 
D)  thromboxane 
E)  progesterone

Question 13

Which of the following can be regulated by eicosanoids?

Accepted Answer

A)  blood pressure 
B)  blood coagulation 
C)  inflammation 
D)  fever 
E)  all of the above 
A)  blood pressure 
B)  blood coagulation 
C)  inflammation 
D)  fever 
E)  all of the above

Question 14

The action of a ___ results in the hydrolysis of cAMP, thus decreasing the signal from ___.

Accepted Answer

phosphodie

Question 15

Which of the following is a ligand of the  $\beta$ 2-adrenergic receptor?

Accepted Answer

A)  tyrosine 
B)  serotonin 
C)  norepinephrine 
D)  caffeine 
E)  adenosine 
A)  tyrosine 
B)  serotonin 
C)  norepinephrine 
D)  caffeine 
E)  adenosine

Question 16

In order for cAMP to ___ protein kinase A, cAMP binds to the ___ subunits.

Accepted Answer

activate,

The ability for some receptor tyrosine kinases to ultimately activate phospholipase C is an example of _____.

A sample of cells with a total receptor concentration of 50 $\mu$ M was incubated with a ligand concentration of 100 $\mu$ M. Following the incubation period, the concentration of unbound receptors was determined to be 15 $\mu$ M. What is the K_d for the receptor-ligand interaction?

The eicosanoids are derived from the membrane fatty acid _____.

The _____ signaling pathway undergoes autophosphorylation, resulting in kinase activation.

The complex formed between a lipid hormone and its receptor binds to _____ which are specific DNA sequences.

Which of the following can be a hormone?

Which of the following hormones is able to cross biological membranes and thus the receptor is found inside the cell, not on the cell surface?

Interaction of the Ras protein with _ results in activation by _

Hormones bind to _ with _ affinity.

When a receptor loses its ability to transmit a signal following continuous exposure to a ligand, the receptor is said to be _____.

Activity of the Ras protein is analogous to the _____ in terms of its ability to bind GTP.

Which of the following is an inhibitor of cyclooxygenase?

Which of the following can be regulated by eicosanoids?

The action of a _ results in the hydrolysis of cAMP, thus decreasing the signal from _.

Which of the following is a ligand of the $\beta$ ₂-adrenergic receptor?

In order for cAMP to _ protein kinase A, cAMP binds to the _ subunits.

The Chemical Basis of Life

Aqueous Chemistry

Nucleic Acid Structure and Function

Protein Structure

Protein Function

How Enzymes Work

Enzyme Kinetics and Inhibition

Lipids and Membranes

Membrane Transport

Carbohydrates

Metabolism and Bioenergetics

Glucose Metabolism

The Citric Acid Cycle

Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Nitrogen Metabolism

Regulation of Mammalian Fuel Metabolism

DNA Replication and Repair

Transcription and RNA

Protein Synthesis

Filters

Exam 10: Signaling

The ability for some receptor tyrosine kinases to ultimately activate phospholipase C is an example of _____.

A sample of cells with a total receptor concentration of 50 μ\muμ M was incubated with a ligand concentration of 100 μ\muμ M. Following the incubation period, the concentration of unbound receptors was determined to be 15 μ\muμ M. What is the Kd for the receptor-ligand interaction?

The eicosanoids are derived from the membrane fatty acid _____.

The _____ signaling pathway undergoes autophosphorylation, resulting in kinase activation.

The complex formed between a lipid hormone and its receptor binds to _____ which are specific DNA sequences.

Which of the following can be a hormone?

Which of the following hormones is able to cross biological membranes and thus the receptor is found inside the cell, not on the cell surface?

Interaction of the Ras protein with ___ results in activation by ___

Hormones bind to _____ with _____ affinity.

When a receptor loses its ability to transmit a signal following continuous exposure to a ligand, the receptor is said to be _____.

Activity of the Ras protein is analogous to the _____ in terms of its ability to bind GTP.

Which of the following is an inhibitor of cyclooxygenase?

Which of the following can be regulated by eicosanoids?

The action of a ___ results in the hydrolysis of cAMP, thus decreasing the signal from ___.

Which of the following is a ligand of the β\betaβ 2-adrenergic receptor?

In order for cAMP to ___ protein kinase A, cAMP binds to the ___ subunits.

The Chemical Basis of Life

Aqueous Chemistry

Nucleic Acid Structure and Function

Protein Structure

Protein Function

How Enzymes Work

Enzyme Kinetics and Inhibition

Lipids and Membranes

Membrane Transport

Carbohydrates

Metabolism and Bioenergetics

Glucose Metabolism

The Citric Acid Cycle

Oxidative Phosphorylation

Photosynthesis

Lipid Metabolism

Nitrogen Metabolism

Regulation of Mammalian Fuel Metabolism

DNA Replication and Repair

Transcription and RNA

Protein Synthesis

Filters

A sample of cells with a total receptor concentration of 50 $\mu$ M was incubated with a ligand concentration of 100 $\mu$ M. Following the incubation period, the concentration of unbound receptors was determined to be 15 $\mu$ M. What is the K_d for the receptor-ligand interaction?

Interaction of the Ras protein with _ results in activation by _

Hormones bind to _ with _ affinity.

The action of a _ results in the hydrolysis of cAMP, thus decreasing the signal from _.

Which of the following is a ligand of the $\beta$ ₂-adrenergic receptor?

In order for cAMP to _ protein kinase A, cAMP binds to the _ subunits.