Question 1

How many protons are moved across the inner mitochondrial membrane at Complex III?

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  4 
E)  none of the above 
A)  1 
B)  2 
C)  3 
D)  4 
E)  none of the above D

Question 2

If the reduction potential for NAD+ is -0.315 V and the reduction potential for oxygen is 0.815 V, what is the potential for the oxidation of NADH by oxygen?

Accepted Answer

A)  -1.13 V 
B)  -0.50 V 
C)  0.185 V 
D)  0.50 V 
E)  1.13 V 
A)  -1.13 V 
B)  -0.50 V 
C)  0.185 V 
D)  0.50 V 
E)  1.13 V E

Question 3

If an ATP synthase has 12 c subunits, how many protons must move through the enzyme to produce one ATP?

Accepted Answer

A)  2.5 
B)  3 
C)  4 
D)  10 
E)  12 
A)  2.5 
B)  3 
C)  4 
D)  10 
E)  12 C

Question 4

What free radical is thought to be commonly produced by the electron transport chain?

Accepted Answer

A)  hydroxyl 
B)  peroxyl 
C)  superoxide 
D)  hydrogen peroxyl 
E)  all of the above 
A)  hydroxyl 
B)  peroxyl 
C)  superoxide 
D)  hydrogen peroxyl 
E)  all of the above

Question 5

How many ATP can be produced from the complete oxidation of glucose if the malate-aspartate shuttle is used?

Accepted Answer

A)  2 
B)  19.5 
C)  28 
D)  30 
E)  32 
A)  2 
B)  19.5 
C)  28 
D)  30 
E)  32

Question 6

The cytochromes undergo which of the following oxidation reactions?

Accepted Answer

A)  Fe3+  $\rarr$ Fe2+ 
B)  Fe0   $\rarr$ Fe2+ 
C)  Fe2+  $\rarr$ Fe3+ 
D)  Cu1+  $\rarr$ Cu2+ 
E)  Cu2+  $\rarr$  Cu1+ 
A)  Fe3+  $\rarr$ Fe2+ 
B)  Fe0   $\rarr$ Fe2+ 
C)  Fe2+  $\rarr$ Fe3+ 
D)  Cu1+  $\rarr$ Cu2+ 
E)  Cu2+  $\rarr$  Cu1+

Question 7

Under normal metabolic conditions, the difference in pH between the matrix and intermembrane space is ___ suggesting that the processes of electron transport and oxidative phosphorylation ___.

Accepted Answer

less than

Question 8

Which of the following transport mechanisms is used in the inner mitochondrial membrane?
 IMS = intermembrane space

Accepted Answer

A)  antiport of ATP from IMS to matrix, ADP from matrix to IMS 
B)  symport of ATP and H+ from matrix to IMS 
C)  symport of Pi and H+ from IMS to matrix 
D)  antiport of ADP from IMS to matrix, Pi from matrix to IMS 
E)  symport of ADP and H+ from IMS to matrix 
A)  antiport of ATP from IMS to matrix, ADP from matrix to IMS 
B)  symport of ATP and H+ from matrix to IMS 
C)  symport of Pi and H+ from IMS to matrix 
D)  antiport of ADP from IMS to matrix, Pi from matrix to IMS 
E)  symport of ADP and H+ from IMS to matrix

Question 9

Which of the following is a source of ubiquinol?

Accepted Answer

A)  Complex I 
B)  fatty acyl-CoA dehydrogenase 
C)  succinate dehydrogenase 
D)  mitochondrial dehydrogenase 
E)  all of the above 
A)  Complex I 
B)  fatty acyl-CoA dehydrogenase 
C)  succinate dehydrogenase 
D)  mitochondrial dehydrogenase 
E)  all of the above

Question 10

In a muscle cell at 37    C, if the concentrations of pyruvate and lactate are 100  $\mu$ M and 50 $\mu$ M respectively, what is the actual reduction potential if   for pyruvate reduction is -0.185 V?

Accepted Answer

A)  -0.194 V 
B)  -0.186 V 
C)  -0.176 V 
D)  0.176 V 
E)  0.194 V 
A)  -0.194 V 
B)  -0.186 V 
C)  -0.176 V 
D)  0.176 V 
E)  0.194 V

Question 11

The F0 component of ATP synthase contains ___ subunits; the F1 component contains ___ subunits.

Accepted Answer

The answer of The F0 component of ATP synthase contains...

Question 12

What is the  $\Delta$ G for the reduction of pyruvate to lactate by NADH given the following half reactions?
Pyruvate- + 2H+ + 2e-  $\rarr$ lactate-  &emsp;  = -0.185
NAD+ + H+ + 2e-  $\rarr$  NADH &emsp;  = -0.315

Accepted Answer

A)  -96.5 kJ/mol 
B)  -25.1 kJ/mol 
C)  -12.5 kJ/mol 
D)  25.1 kJ/mol 
E)  96.5 kJ/mol 
A)  -96.5 kJ/mol 
B)  -25.1 kJ/mol 
C)  -12.5 kJ/mol 
D)  25.1 kJ/mol 
E)  96.5 kJ/mol

Question 13

What is the P/O ratio for the oxidation of ubiquinone if three protons are required to synthesize one ATP?

Accepted Answer

A)  1 
B)  1.5 
C)  2 
D)  3 
E)  3.3 
A)  1 
B)  1.5 
C)  2 
D)  3 
E)  3.3

Question 14

Which subunit of ATP synthase is responsible for the catalysis of ATP formation?

Accepted Answer

A)  a 
B)  c 
C)   $\alpha$ 
D)   $\beta$ 
E)   $\gamma$ 
A)  a 
B)  c 
C)   $\alpha$ 
D)   $\beta$ 
E)   $\gamma$

Question 15

What genes are found in the mitochondrial genome?

Accepted Answer

A)  electron transport proteins 
B)  citric acid cycle enzymes 
C)  fatty acid oxidation enzymes 
D)  outer membrane transport proteins 
E)  none of the above 
A)  electron transport proteins 
B)  citric acid cycle enzymes 
C)  fatty acid oxidation enzymes 
D)  outer membrane transport proteins 
E)  none of the above

Question 16

The oxidation of FADH2 to FAD involves the transfer of _____; the oxidation of NADH to NAD+ involves the transfer of _____.

Accepted Answer

A)  a hydrogen atom and an H+; a hydride 
B)  two hydrogen atoms; a hydride 
C)  a hydride and an H+; a hydrogen atom and an H+ 
D)  a hydride; two hydrogen atoms 
E)  two hydrides; one hydride 
A)  a hydrogen atom and an H+; a hydride 
B)  two hydrogen atoms; a hydride 
C)  a hydride and an H+; a hydrogen atom and an H+ 
D)  a hydride; two hydrogen atoms 
E)  two hydrides; one hydride

Question 17

What does the reduction potential of 0.815 V for the reduction of water to oxygen indicate?

Accepted Answer

A)  water is a very strong reducing agent 
B)  water is a very strong reducing agent and oxygen is a very strong oxidizing agent 
C)  oxygen is a very strong oxidizing agent 
D)  water will be spontaneously reduced to oxygen 
E)  none of the above 
A)  water is a very strong reducing agent 
B)  water is a very strong reducing agent and oxygen is a very strong oxidizing agent 
C)  oxygen is a very strong oxidizing agent 
D)  water will be spontaneously reduced to oxygen 
E)  none of the above

Question 18

Which of the following is the correct half reaction for the oxidation of acetaldehyde?

Accepted Answer

A)  acetaldehyde + H2O  $\rarr$  acetate- + 3H+ + 2e- 
B)  acetate- + 3H+ + 2e-  $\rarr$  acetaldehyde + H2O 
C)  acetaldehyde + 2 H+ + 2e-  $\rarr$  ethanol 
D)  ethanol  $\rarr$  acetaldehyde + 2 H+ + 2e- 
E)  acetaldehyde + CO2 + H+ + 2e-  $\rarr$  pyruvate- 
A)  acetaldehyde + H2O  $\rarr$  acetate- + 3H+ + 2e- 
B)  acetate- + 3H+ + 2e-  $\rarr$  acetaldehyde + H2O 
C)  acetaldehyde + 2 H+ + 2e-  $\rarr$  ethanol 
D)  ethanol  $\rarr$  acetaldehyde + 2 H+ + 2e- 
E)  acetaldehyde + CO2 + H+ + 2e-  $\rarr$  pyruvate-

Question 19

If the following half-reactions are combined, what is the potential for the spontaneous reaction?
Oxaloacetate- + 2H+ + 2e-  $\rarr$ malate-    = -0.166
NAD+ + H+ + 2e- $\rarr$ NADH  = -0.315

Accepted Answer

A)  -0.481 V 
B)  -0.149 V 
C)  0.0523 V 
D)  0.149 V 
E)  .0481 V 
A)  -0.481 V 
B)  -0.149 V 
C)  0.0523 V 
D)  0.149 V 
E)  .0481 V

Question 20

Ubiquinone is a _____ molecule that serves as a _____ electron carrier; cytochrome c is a _____ molecule that serves as a _____ electron carrier.

Accepted Answer

A)  hydrophobic; 2; hydrophilic; 1 
B)  hydrophobic; 1; hydrophilic; 1 
C)  hydrophilic; 2; hydrophobic; 2 
D)  hydrophilic; 2; hydrophobic; 1 
E)  hydrophobic; 1; hydrophilic; 2 
A)  hydrophobic; 2; hydrophilic; 1 
B)  hydrophobic; 1; hydrophilic; 1 
C)  hydrophilic; 2; hydrophobic; 2 
D)  hydrophilic; 2; hydrophobic; 1 
E)  hydrophobic; 1; hydrophilic; 2

How many protons are moved across the inner mitochondrial membrane at Complex III?

If the reduction potential for NAD⁺ is -0.315 V and the reduction potential for oxygen is 0.815 V, what is the potential for the oxidation of NADH by oxygen?

If an ATP synthase has 12 c subunits, how many protons must move through the enzyme to produce one ATP?

What free radical is thought to be commonly produced by the electron transport chain?

How many ATP can be produced from the complete oxidation of glucose if the malate-aspartate shuttle is used?

The cytochromes undergo which of the following oxidation reactions?

Under normal metabolic conditions, the difference in pH between the matrix and intermembrane space is _ suggesting that the processes of electron transport and oxidative phosphorylation _.

Which of the following transport mechanisms is used in the inner mitochondrial membrane? IMS = intermembrane space

Which of the following is a source of ubiquinol?

The F₀ component of ATP synthase contains _ subunits; the F1 component contains _ subunits.

What is the P/O ratio for the oxidation of ubiquinone if three protons are required to synthesize one ATP?

Which subunit of ATP synthase is responsible for the catalysis of ATP formation?

What genes are found in the mitochondrial genome?

The oxidation of FADH₂ to FAD involves the transfer of _; the oxidation of NADH to NAD⁺ involves the transfer of _.

What does the reduction potential of 0.815 V for the reduction of water to oxygen indicate?

Which of the following is the correct half reaction for the oxidation of acetaldehyde?

Ubiquinone is a ___ molecule that serves as a _ electron carrier; cytochrome c is a _ molecule that serves as a ___ electron carrier.

The Chemical Basis of Life

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How Enzymes Work

Enzyme Kinetics and Inhibition

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Metabolism and Bioenergetics

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The Citric Acid Cycle

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Exam 15: Oxidative Phosphorylation

How many protons are moved across the inner mitochondrial membrane at Complex III?

If the reduction potential for NAD+ is -0.315 V and the reduction potential for oxygen is 0.815 V, what is the potential for the oxidation of NADH by oxygen?

If an ATP synthase has 12 c subunits, how many protons must move through the enzyme to produce one ATP?

What free radical is thought to be commonly produced by the electron transport chain?

How many ATP can be produced from the complete oxidation of glucose if the malate-aspartate shuttle is used?

The cytochromes undergo which of the following oxidation reactions?

Under normal metabolic conditions, the difference in pH between the matrix and intermembrane space is ___ suggesting that the processes of electron transport and oxidative phosphorylation ___.

Which of the following transport mechanisms is used in the inner mitochondrial membrane? IMS = intermembrane space

Which of the following is a source of ubiquinol?

In a muscle cell at 37 C, if the concentrations of pyruvate and lactate are 100 μ\muμ M and 50 μ\muμ M respectively, what is the actual reduction potential if for pyruvate reduction is -0.185 V?

The F0 component of ATP synthase contains ___ subunits; the F1 component contains ___ subunits.

What is the Δ\DeltaΔ Gfor the reduction of pyruvate to lactate by NADH given the following half reactions? Pyruvate- + 2H+ + 2e- →\rarr→ lactate- = -0.185 NAD+ + H+ + 2e- →\rarr→ NADH 11ee7c6d_c899_8e54_ae82_0910aec0b20b_TBW1044_11= -0.315

What is the P/O ratio for the oxidation of ubiquinone if three protons are required to synthesize one ATP?

Which subunit of ATP synthase is responsible for the catalysis of ATP formation?

What genes are found in the mitochondrial genome?

The oxidation of FADH2 to FAD involves the transfer of _____; the oxidation of NADH to NAD+ involves the transfer of _____.

What does the reduction potential of 0.815 V for the reduction of water to oxygen indicate?

Which of the following is the correct half reaction for the oxidation of acetaldehyde?

If the following half-reactions are combined, what is the potential for the spontaneous reaction? Oxaloacetate- + 2H+ + 2e- →\rarr→ malate- = -0.166 NAD+ + H+ + 2e- →\rarr→ NADH 11ee7c6d_74e2_e452_ae82_f5f2b4bfa620_TBW1044_11= -0.315

Ubiquinone is a _____ molecule that serves as a _____ electron carrier; cytochrome c is a _____ molecule that serves as a _____ electron carrier.

The Chemical Basis of Life

Aqueous Chemistry

Nucleic Acid Structure and Function

Protein Structure

Protein Function

How Enzymes Work

Enzyme Kinetics and Inhibition

Lipids and Membranes

Membrane Transport

Signaling

Carbohydrates

Metabolism and Bioenergetics

Glucose Metabolism

The Citric Acid Cycle

Photosynthesis

Lipid Metabolism

Nitrogen Metabolism

Regulation of Mammalian Fuel Metabolism

DNA Replication and Repair

Transcription and RNA

Protein Synthesis

Filters

If the reduction potential for NAD⁺ is -0.315 V and the reduction potential for oxygen is 0.815 V, what is the potential for the oxidation of NADH by oxygen?

Under normal metabolic conditions, the difference in pH between the matrix and intermembrane space is _ suggesting that the processes of electron transport and oxidative phosphorylation _.

The F₀ component of ATP synthase contains _ subunits; the F1 component contains _ subunits.

The oxidation of FADH₂ to FAD involves the transfer of _; the oxidation of NADH to NAD⁺ involves the transfer of _.

Ubiquinone is a ___ molecule that serves as a _ electron carrier; cytochrome c is a _ molecule that serves as a ___ electron carrier.