Question 1

Which of the following drug strategies would NOT be indicated in conditions like deep vein thrombosis (DVT)?

Accepted Answer

A)  drugs that increase the ability of antithrombin to inhibit the activity of several clotting factors (e.g., heparin) 
B)  drugs that inhibit vitamin K metabolism in the liver (e.g., warfarin) 
C)  drugs that inhibit fibrinolysis (e.g., aminocaproic acid [Amicar], tranexamic acid [Cyklokapron]) 
D)  drugs that directly inhibit the active form for clotting factor X (e.g., fondaparinux [Arixtra], rivaroxaban [Xarelto]) 
E)  drugs that directly inhibit thrombin activity (e.g., lepirudin [Refludan], dabigatran [Pradaxa]) 
A)  drugs that increase the ability of antithrombin to inhibit the activity of several clotting factors (e.g., heparin) 
B)  drugs that inhibit vitamin K metabolism in the liver (e.g., warfarin) 
C)  drugs that inhibit fibrinolysis (e.g., aminocaproic acid [Amicar], tranexamic acid [Cyklokapron]) 
D)  drugs that directly inhibit the active form for clotting factor X (e.g., fondaparinux [Arixtra], rivaroxaban [Xarelto]) 
E)  drugs that directly inhibit thrombin activity (e.g., lepirudin [Refludan], dabigatran [Pradaxa]) C

Question 2

Oral anticoagulants such as warfarin (Coumadin)decrease the production of several clotting factors in the liver by interfering with the regeneration of

Accepted Answer

A)  tissue thromboplastin 
B)  tissue plasminogen activator 
C)  vitamin K 
D)  vitamin D 
E)  vitamin C 
A)  tissue thromboplastin 
B)  tissue plasminogen activator 
C)  vitamin K 
D)  vitamin D 
E)  vitamin C C

Question 3

Thrombolytic drugs may be helpful in treating an acute cerebrovascular accident (stroke)if

Accepted Answer

A)  they are administered 8 to 10 hours after the onset of symptoms 
B)  they are administered orally 
C)  the stroke is ischemic in nature 
D)  all the above are true 
A)  they are administered 8 to 10 hours after the onset of symptoms 
B)  they are administered orally 
C)  the stroke is ischemic in nature 
D)  all the above are true C

Question 4

Patient taking statins to improve plasma lipid profiles may be at increased risk for statin-induced myopathy if they

Accepted Answer

A)  are elderly 
B)  have multiple diseases 
C)  have frail stature 
D)  are taking immunosuppressant drugs 
E)  all the above 
A)  are elderly 
B)  have multiple diseases 
C)  have frail stature 
D)  are taking immunosuppressant drugs 
E)  all the above

Question 5

All of the following drugs will inhibit platelet-induced clots EXCEPT

Accepted Answer

A)  adenosine diphosphate (ADP) receptor blockers such as clopidogrel (Plavix) and ticlopidine (Ticlid) 
B)  glycoprotein (GP) IIb-IIIa receptor blockers such as abciximab (ReoPro) and eptifibatide (Integrilin) 
C)  anti-gout drugs such as sulfinpyrazone (Anturane) 
D)  acetaminophen products such as Tylenol 
E)  aspirin 
A)  adenosine diphosphate (ADP) receptor blockers such as clopidogrel (Plavix) and ticlopidine (Ticlid) 
B)  glycoprotein (GP) IIb-IIIa receptor blockers such as abciximab (ReoPro) and eptifibatide (Integrilin) 
C)  anti-gout drugs such as sulfinpyrazone (Anturane) 
D)  acetaminophen products such as Tylenol 
E)  aspirin

Question 6

Low molecular weight heparins such as enoxaparin are often preferred to more traditional (unfractionated)heparin because low molecular weight heparins

Accepted Answer

A)  can be administered subcutaneously 
B)  usually do not need to be administered as frequently as traditional heparin 
C)  provide more predictable anticoagulant effects 
D)  all the above are true 
E)  none of the above are true 
A)  can be administered subcutaneously 
B)  usually do not need to be administered as frequently as traditional heparin 
C)  provide more predictable anticoagulant effects 
D)  all the above are true 
E)  none of the above are true

Question 7

Drug management in hemophilia consists of giving drugs that

Accepted Answer

A)  inhibit thrombin formation. 
B)  inhibit Vitamin K activity 
C)  increase fibrinolysin activity 
D)  inhibit platelet function. 
E)  treatment consists of administering the missing clotting factor(s) 
A)  inhibit thrombin formation. 
B)  inhibit Vitamin K activity 
C)  increase fibrinolysin activity 
D)  inhibit platelet function. 
E)  treatment consists of administering the missing clotting factor(s)

Question 8

Statin drugs such atorvastatin (Lipitor)and simvastatin (Zocor)inhibit the HMG-CoA reductase enzyme,thereby ______ the production of ______.

Accepted Answer

A)  increasing; cholesterol 
B)  decreasing; cholesterol 
C)  increasing; low-density lipoproteins 
D)  decreasing; high-density lipoproteins 
E)  increasing; triglycerides 
A)  increasing; cholesterol 
B)  decreasing; cholesterol 
C)  increasing; low-density lipoproteins 
D)  decreasing; high-density lipoproteins 
E)  increasing; triglycerides

Question 9

Patients who develop muscle pain and weakness when taking lipid lowering drugs such as atorvastatin (Lipitor)and simvastatin (Zocor)

Accepted Answer

A)  should continue on the lipid lowering drugs because these muscle symptoms are usually not severe 
B)  should continue on the lipid lowering drugs but resolve the muscle pain through strenuous resistance exercises 
C)  should continue on the lipid lowering drugs but take an analgesic such as aspirin to control the pain 
D)  should be removed immediately from the drug because these symptoms may represent potentially serious myopathies 
E)  these drugs are not associated with muscle pain or weakness 
A)  should continue on the lipid lowering drugs because these muscle symptoms are usually not severe 
B)  should continue on the lipid lowering drugs but resolve the muscle pain through strenuous resistance exercises 
C)  should continue on the lipid lowering drugs but take an analgesic such as aspirin to control the pain 
D)  should be removed immediately from the drug because these symptoms may represent potentially serious myopathies 
E)  these drugs are not associated with muscle pain or weakness

Question 10

In a patient with acute deep vein thrombosis (DVT),anticoagulant therapy is typically initiated with _____ to achieve rapid control of clotting,and then switched over to _____ for long-term management or prevention of DVT.

Accepted Answer

A)  heparin; oral anticoagulants 
B)  oral anticoagulants; thrombin 
C)  thrombin; tissue plasminogen activator 
D)  tissue plasminogen activator; fibrinolysis inhibitors 
E)  oral anticoagulants; heparin 
A)  heparin; oral anticoagulants 
B)  oral anticoagulants; thrombin 
C)  thrombin; tissue plasminogen activator 
D)  tissue plasminogen activator; fibrinolysis inhibitors 
E)  oral anticoagulants; heparin

Question 11

A patient is in the process of having a heart attack due to the sudden formation of an arterial thrombus in his coronary artery.To break up the clot and save the patient's life,the best drug to use is

Accepted Answer

A)  a low-molecular weight heparin (e.g., enoxaparin) 
B)  a fibrinolytic drug (e.g. streptokinase or tP
A)  
C)  a fibrinolysis inhibitor (e.g., aminocaproic acid) 
D)  warfarin (Coumadin) 
E)  vitamin K 
A)  a low-molecular weight heparin (e.g., enoxaparin) 
B)  a fibrinolytic drug (e.g. streptokinase or tP
A)  
C)  a fibrinolysis inhibitor (e.g., aminocaproic acid) 
D)  warfarin (Coumadin) 
E)  vitamin K

Question 12

Because of its ability to inhibit platelet activity,aspirin is used to prevent

Accepted Answer

A)  myocardial infarction 
B)  ischemic stroke 
C)  hemorrhagic stroke 
D)  all the above are true 
E)  A and B only are true 
A)  myocardial infarction 
B)  ischemic stroke 
C)  hemorrhagic stroke 
D)  all the above are true 
E)  A and B only are true

Exam 25: Treatment of Coagulation Disorders and Hyperlipidemia

Which of the following drug strategies would NOT be indicated in conditions like deep vein thrombosis (DVT)?

Oral anticoagulants such as warfarin (Coumadin)decrease the production of several clotting factors in the liver by interfering with the regeneration of

Thrombolytic drugs may be helpful in treating an acute cerebrovascular accident (stroke)if

Patient taking statins to improve plasma lipid profiles may be at increased risk for statin-induced myopathy if they

All of the following drugs will inhibit platelet-induced clots EXCEPT

Low molecular weight heparins such as enoxaparin are often preferred to more traditional (unfractionated)heparin because low molecular weight heparins

Drug management in hemophilia consists of giving drugs that

Statin drugs such atorvastatin (Lipitor)and simvastatin (Zocor)inhibit the HMG-CoA reductase enzyme,thereby ______ the production of ______.

Patients who develop muscle pain and weakness when taking lipid lowering drugs such as atorvastatin (Lipitor)and simvastatin (Zocor)

In a patient with acute deep vein thrombosis (DVT),anticoagulant therapy is typically initiated with _____ to achieve rapid control of clotting,and then switched over to _____ for long-term management or prevention of DVT.

A patient is in the process of having a heart attack due to the sudden formation of an arterial thrombus in his coronary artery.To break up the clot and save the patient's life,the best drug to use is

Because of its ability to inhibit platelet activity,aspirin is used to prevent

Basic Principles of Pharmacology

Pharmacokinetics IDrug Administration,Absorption,and Distribution

Pharmacokinetics II: Drug Elimination

Drug Receptors

General Principles of Central Nervous System Pharmacology

Sedative Hypnotic and Anti-anxiety Agents

Drugs to Treat Affective Disorders Depression and Bipolar Syndrome

Antipsychotic Drugs

Antiepileptic Drugs

Pharmacologic Management of Parkinson Disease

General Anesthetics

Local Anesthetics

Skeletal Muscle Relaxants

Opioid Analgesics

Non-steroidal Anti Inflammatory Drugs

Pharmacologic Management of Rheumatoid Arthritis and Osteoarthritis

Patient Controlled Analgesia

Introduction to Autonomic Pharmacology

Cholinergic Drugs

Adrenergic Drugs

Antihypertensive Drugs

Treatment of Angina Pectoris

Treatment of Cardiac Arrhythmias

Treatment of Congestive Heart Failure

Respiratory Drugs

Gastrointestinal Drugs

Introduction to Endocrine Pharmacology

Adrenocorticosteroids

Male and Female Hormones

Thyroid and Parathyroid Drugs: Agents Affecting Bone Mineralization

Pancreatic Hormones and the Treatment of Diabetes Mellitus

Treatment of Infections I: Antibacterial Drugs

Treatment of Infections II: Antiviral Drugs

Treatment of Infections III: Antifungal and Antiparasitic Drugs

Cancer Chemotherapy

Immunomodulating Agents

Filters

Statin drugs such atorvastatin (Lipitor)and simvastatin (Zocor)inhibit the HMG-CoA reductase enzyme,thereby the production of .

In a patient with acute deep vein thrombosis (DVT),anticoagulant therapy is typically initiated with _ to achieve rapid control of clotting,and then switched over to _ for long-term management or prevention of DVT.