Question 1

NSAIDs such as aspirin exhibit all of the following effects EXCEPT

Accepted Answer

A)  the ability to decrease inflammation 
B)  the ability to increase bronchodilation in conditions such as asthma 
C)  the ability to relieve mild-to-moderate pain (analgesia) 
D)  the ability to decrease the elevated body temperature associated with fever (antipyresis) 
E)  the ability to decrease blood clotting by inhibiting platelet aggregation (anticoagulation) 
A)  the ability to decrease inflammation 
B)  the ability to increase bronchodilation in conditions such as asthma 
C)  the ability to relieve mild-to-moderate pain (analgesia) 
D)  the ability to decrease the elevated body temperature associated with fever (antipyresis) 
E)  the ability to decrease blood clotting by inhibiting platelet aggregation (anticoagulation) B

Question 2

High doses of acetaminophen (e.g.,15 g)can be especially toxic to the:

Accepted Answer

A)  heart 
B)  liver 
C)  kidneys 
D)  stomach 
E)  brain 
A)  heart 
B)  liver 
C)  kidneys 
D)  stomach 
E)  brain B

Question 3

Aspirin and other NSAIDs exert their primary therapeutic effects by interfering with the biosynthesis of

Accepted Answer

A)  leukotrienes 
B)  catecholamines 
C)  prostaglandins 
D)  cyclic AMP 
E)  endogenous opioids 
A)  leukotrienes 
B)  catecholamines 
C)  prostaglandins 
D)  cyclic AMP 
E)  endogenous opioids C

Question 4

Gastric irritation caused by aspirin and other NSAIDs can be treated with

Accepted Answer

A)  drugs that mimic prostaglandins (PGs) such as PGE1 (e.g., misoprostol [Cytotec]) 
B)  gastric proton pump inhibitors (PPIs) such as omeprazole (Prilosec) and esomeprazole (Nexium) 
C)  histamine type 2 (H2) blockers such as cimetidine (Tagamet) and ranitidine (Zantac) 
D)  all the above 
E)  none of the above 
A)  drugs that mimic prostaglandins (PGs) such as PGE1 (e.g., misoprostol [Cytotec]) 
B)  gastric proton pump inhibitors (PPIs) such as omeprazole (Prilosec) and esomeprazole (Nexium) 
C)  histamine type 2 (H2) blockers such as cimetidine (Tagamet) and ranitidine (Zantac) 
D)  all the above 
E)  none of the above

Question 5

Prostaglandins are

Accepted Answer

A)  small proteins that inhibit cellular inflammation 
B)  a specific type of lymphocyte involved in the inflammatory process 
C)  carbohydrates that regulate cell division 
D)  steroids that increase cellular metabolism 
E)  none of the above are true 
A)  small proteins that inhibit cellular inflammation 
B)  a specific type of lymphocyte involved in the inflammatory process 
C)  carbohydrates that regulate cell division 
D)  steroids that increase cellular metabolism 
E)  none of the above are true

Question 6

NSAIDs exert their therapeutic effects by _____ the ______ enzyme.

Accepted Answer

A)  inhibiting; cyclooxygenase 
B)  stimulating; cyclooxygenase 
C)  inhibiting; acetylcholinesterase 
D)  stimulating; acetylcholinesterase 
E)  inhibiting; monoamine oxidase type A 
A)  inhibiting; cyclooxygenase 
B)  stimulating; cyclooxygenase 
C)  inhibiting; acetylcholinesterase 
D)  stimulating; acetylcholinesterase 
E)  inhibiting; monoamine oxidase type A

Question 7

The _____ form of the cyclooxygenase enzyme seems to be responsible for producing beneficial prostaglandins that help maintain or protect function in specific tissues such as the stomach and kidneys.

Accepted Answer

A)  COX-1 
B)  COX-2 
C)  COX-3 
D)  COX-4 
E)  no prostaglandins are beneficial in any tissues 
A)  COX-1 
B)  COX-2 
C)  COX-3 
D)  COX-4 
E)  no prostaglandins are beneficial in any tissues

Question 8

Several COX-2 selective inhibitors such as rofecoxib (Vioxx)and valdecoxib (Bextra)have been taken off the market because these drugs can cause serious side effects such as

Accepted Answer

A)  liver failure 
B)  brain tumors 
C)  heart attack and stroke 
D)  kidney failure 
E)  skeletal muscle inflammation and myopathy 
A)  liver failure 
B)  brain tumors 
C)  heart attack and stroke 
D)  kidney failure 
E)  skeletal muscle inflammation and myopathy

Question 9

Aspirin ______ be used to treat fever in children because this drug may cause _____.

Accepted Answer

A)  should; elevated body temperature 
B)  should not; elevated body temperature 
C)  should; Reye syndrome 
D)  should not; Reye syndrome 
E)  should; aspirin intoxication 
A)  should; elevated body temperature 
B)  should not; elevated body temperature 
C)  should; Reye syndrome 
D)  should not; Reye syndrome 
E)  should; aspirin intoxication

Question 10

Aspirin and acetaminophen are different because

Accepted Answer

A)  acetaminophen is less toxic to the liver than aspirin 
B)  acetaminophen is more toxic to the stomach than aspirin 
C)  acetaminophen does not have antipyretic effects 
D)  acetaminophen does not have anti-inflammatory effects 
E)  none of the above are true; aspirin and acetaminophen are virtually identical in terms of therapeutic effects and side effects 
A)  acetaminophen is less toxic to the liver than aspirin 
B)  acetaminophen is more toxic to the stomach than aspirin 
C)  acetaminophen does not have antipyretic effects 
D)  acetaminophen does not have anti-inflammatory effects 
E)  none of the above are true; aspirin and acetaminophen are virtually identical in terms of therapeutic effects and side effects

Question 11

Which of the following conditions is not normally treated with aspirin or other NSAIDs?

Accepted Answer

A)  mild to moderate pain 
B)  mild to moderate inflammation 
C)  fever in adults 
D)  asthma 
E)  recurrent heart attacks 
A)  mild to moderate pain 
B)  mild to moderate inflammation 
C)  fever in adults 
D)  asthma 
E)  recurrent heart attacks

Question 12

The most common problem associated with NSAIDs such as aspirin is

Accepted Answer

A)  fever 
B)  dizziness 
C)  gastrointestinal damage 
D)  sedation 
E)  suppression of adrenal cortex activity 
A)  fever 
B)  dizziness 
C)  gastrointestinal damage 
D)  sedation 
E)  suppression of adrenal cortex activity

Question 13

In theory,a COX-2 selective drug such as celecoxib will be less likely to cause gastric irritation because

Accepted Answer

A)  COX-2 drugs are less acidic than traditional NSAIDs 
B)  COX-2 drugs do not inhibit the production of beneficial prostaglandins in the stomach 
C)  patients taking COX-2 drugs are older than patients taking traditional NSAIDs 
D)  COX-2 drugs are coated so that the drug does not dissolve until it reaches the small intestine. 
E)  all the above are true 
A)  COX-2 drugs are less acidic than traditional NSAIDs 
B)  COX-2 drugs do not inhibit the production of beneficial prostaglandins in the stomach 
C)  patients taking COX-2 drugs are older than patients taking traditional NSAIDs 
D)  COX-2 drugs are coated so that the drug does not dissolve until it reaches the small intestine. 
E)  all the above are true

Question 14

In addition to its analgesic and anti-inflammatory effects,it appears that regular use of low-dose aspirin may also help prevent

Accepted Answer

A)  heart attacks 
B)  ischemic strokes 
C)  colorectal cancer 
D)  all the above are true 
E)  none of the above are true 
A)  heart attacks 
B)  ischemic strokes 
C)  colorectal cancer 
D)  all the above are true 
E)  none of the above are true

Question 15

It has been suggested that aspirin and other NSAIDs _______ be used to treat pain following surgeries such as spinal fusion because these drugs may ______.

Accepted Answer

A)  should not; inhibit bone healing 
B)  should; inhibit bone healing 
C)  should not; enhance bone healing 
D)  should; enhance bone healing 
E)  should not; cause excessive sedation and psychotropic effects (hallucinations, etc.) 
A)  should not; inhibit bone healing 
B)  should; inhibit bone healing 
C)  should not; enhance bone healing 
D)  should; enhance bone healing 
E)  should not; cause excessive sedation and psychotropic effects (hallucinations, etc.)

Exam 15: Non-steroidal Anti Inflammatory Drugs

NSAIDs such as aspirin exhibit all of the following effects EXCEPT

High doses of acetaminophen (e.g.,15 g)can be especially toxic to the:

Aspirin and other NSAIDs exert their primary therapeutic effects by interfering with the biosynthesis of

Gastric irritation caused by aspirin and other NSAIDs can be treated with

Prostaglandins are

NSAIDs exert their therapeutic effects by _____ the ______ enzyme.

The _____ form of the cyclooxygenase enzyme seems to be responsible for producing beneficial prostaglandins that help maintain or protect function in specific tissues such as the stomach and kidneys.

Several COX-2 selective inhibitors such as rofecoxib (Vioxx)and valdecoxib (Bextra)have been taken off the market because these drugs can cause serious side effects such as

Aspirin ______ be used to treat fever in children because this drug may cause _____.

Aspirin and acetaminophen are different because

Which of the following conditions is not normally treated with aspirin or other NSAIDs?

The most common problem associated with NSAIDs such as aspirin is

In theory,a COX-2 selective drug such as celecoxib will be less likely to cause gastric irritation because

In addition to its analgesic and anti-inflammatory effects,it appears that regular use of low-dose aspirin may also help prevent

It has been suggested that aspirin and other NSAIDs _______ be used to treat pain following surgeries such as spinal fusion because these drugs may ______.

Basic Principles of Pharmacology

Pharmacokinetics IDrug Administration,Absorption,and Distribution

Pharmacokinetics II: Drug Elimination

Drug Receptors

General Principles of Central Nervous System Pharmacology

Sedative Hypnotic and Anti-anxiety Agents

Drugs to Treat Affective Disorders Depression and Bipolar Syndrome

Antipsychotic Drugs

Antiepileptic Drugs

Pharmacologic Management of Parkinson Disease

General Anesthetics

Local Anesthetics

Skeletal Muscle Relaxants

Opioid Analgesics

Pharmacologic Management of Rheumatoid Arthritis and Osteoarthritis

Patient Controlled Analgesia

Introduction to Autonomic Pharmacology

Cholinergic Drugs

Adrenergic Drugs

Antihypertensive Drugs

Treatment of Angina Pectoris

Treatment of Cardiac Arrhythmias

Treatment of Congestive Heart Failure

Treatment of Coagulation Disorders and Hyperlipidemia

Respiratory Drugs

Gastrointestinal Drugs

Introduction to Endocrine Pharmacology

Adrenocorticosteroids

Male and Female Hormones

Thyroid and Parathyroid Drugs: Agents Affecting Bone Mineralization

Pancreatic Hormones and the Treatment of Diabetes Mellitus

Treatment of Infections I: Antibacterial Drugs

Treatment of Infections II: Antiviral Drugs

Treatment of Infections III: Antifungal and Antiparasitic Drugs

Cancer Chemotherapy

Immunomodulating Agents

Filters

NSAIDs exert their therapeutic effects by _ the __ enzyme.

Aspirin __ be used to treat fever in children because this drug may cause _.

It has been suggested that aspirin and other NSAIDs _ be used to treat pain following surgeries such as spinal fusion because these drugs may .