Question 1

Tendon pain and inflammation (tendinopathy)that can be severe and ultimately lead to tendon rupture may be caused by

Accepted Answer

A)  penicillins 
B)  tetracyclines 
C)  vancomycin 
D)  aminoglycosides such as gentamicin and streptomycin 
E)  fluoroquinolones such as ofloxacin 
A)  penicillins 
B)  tetracyclines 
C)  vancomycin 
D)  aminoglycosides such as gentamicin and streptomycin 
E)  fluoroquinolones such as ofloxacin E

Question 2

Bacteria can become resistant to antibacterial drugs by

Accepted Answer

A)  developing enzymes that destroy the drug 
B)  modifying or masking the site where the antibacterial drug typically binds on or within the bacterial cell 
C)  modifying the bacterial enzymes normally targeted by the drug 
D)  developing drug efflux pumps that expel the drug from the bacterial cell 
E)  all the above are true 
A)  developing enzymes that destroy the drug 
B)  modifying or masking the site where the antibacterial drug typically binds on or within the bacterial cell 
C)  modifying the bacterial enzymes normally targeted by the drug 
D)  developing drug efflux pumps that expel the drug from the bacterial cell 
E)  all the above are true E

Question 3

Aminoglycosides,erythromycin,the tetracyclines,and several other antibacterial drugs affect the function of the bacterial _______,thereby impairing______ in the bacterial cell.

Accepted Answer

A)  nucleus; messenger RNA transcription 
B)  ribosome; messenger RNA translation 
C)  membrane; active transport 
D)  ribosome; passive diffusion 
E)  nucleus; messenger RNA translation 
A)  nucleus; messenger RNA transcription 
B)  ribosome; messenger RNA translation 
C)  membrane; active transport 
D)  ribosome; passive diffusion 
E)  nucleus; messenger RNA translation B

Question 4

Penicillin,cephalosporins,and several other commonly used antibacterial drugs exert their antibacterial effects by inhibiting the function of ______,which results in impaired production of _________ that are essential for normal membrane structure and function.

Accepted Answer

A)  folic acid; nucleic acids 
B)  penicillin-binding proteins; ribosomes 
C)  folic acid; ribosomes 
D)  penicillin-binding proteins; peptidoglycans 
E)  nucleic acids; folic acids 
A)  folic acid; nucleic acids 
B)  penicillin-binding proteins; ribosomes 
C)  folic acid; ribosomes 
D)  penicillin-binding proteins; peptidoglycans 
E)  nucleic acids; folic acids

Question 5

Antibacterial drugs work by all of the following mechanisms EXCEPT inhibition of

Accepted Answer

A)  bacterial intracellular calcium release 
B)  bacterial cell wall synthesis and function 
C)  bacterial protein synthesis 
D)  bacterial nucleic acid synthesis 
E)  none of the above are true; antibacterial drugs use all the mechanisms listed 
A)  bacterial intracellular calcium release 
B)  bacterial cell wall synthesis and function 
C)  bacterial protein synthesis 
D)  bacterial nucleic acid synthesis 
E)  none of the above are true; antibacterial drugs use all the mechanisms listed

Question 6

To limit the development of bacteria that are resistant to drug therapy,it is encouraged that

Accepted Answer

A)  a broad spectrum drug should be used instead of a narrow spectrum agent 
B)  antibacterial drugs should be administered even before performing culture and sensitivity tests that identify the pathogenic bacteria 
C)  antiviral drugs should be administered along with antibacterial agents 
D)  all the above 
E)  none of the above 
A)  a broad spectrum drug should be used instead of a narrow spectrum agent 
B)  antibacterial drugs should be administered even before performing culture and sensitivity tests that identify the pathogenic bacteria 
C)  antiviral drugs should be administered along with antibacterial agents 
D)  all the above 
E)  none of the above

Question 7

Beta-lactamase inhibitors such as clavulanate,sulbactam,and tazobactam are typically combined with a specific type of penicillin

Accepted Answer

A)  to increase the absorption of penicillin from the GI tract 
B)  to enhance the penetration of penicillin into the bacterial cell 
C)  to prevent the beta-lactamase enzyme from destroying the penicillin 
D)  to prevent excessive excretion of the penicillin from the kidneys (i.e., more penicillin is retained in the body) 
E)  none of the above are true 
A)  to increase the absorption of penicillin from the GI tract 
B)  to enhance the penetration of penicillin into the bacterial cell 
C)  to prevent the beta-lactamase enzyme from destroying the penicillin 
D)  to prevent excessive excretion of the penicillin from the kidneys (i.e., more penicillin is retained in the body) 
E)  none of the above are true

Question 8

Rehabilitation interventions that use ultraviolet irradiation (UV light)should be used cautiously in people taking antibacterial drugs because antibacterial drugs may cause

Accepted Answer

A)  pulmonary edema 
B)  photosensitivity 
C)  renal failure 
D)  tendinopathy 
E)  rhabdomyolisis 
A)  pulmonary edema 
B)  photosensitivity 
C)  renal failure 
D)  tendinopathy 
E)  rhabdomyolisis

Question 9

Certain antibacterial drugs such as trimethoprim and the sulfonamide drugs (e.g.,sulfadiazine,sulfamethoxazole)selectively inhibit the synthesis and function of nucleic acids and certain essential amino acids by impairing the production of ______ in bacterial cells.

Accepted Answer

A)  ATP 
B)  glucose 
C)  folic acid 
D)  fatty acids 
E)  mitochondria 
A)  ATP 
B)  glucose 
C)  folic acid 
D)  fatty acids 
E)  mitochondria

Exam 33: Treatment of Infections I: Antibacterial Drugs

Tendon pain and inflammation (tendinopathy)that can be severe and ultimately lead to tendon rupture may be caused by

Bacteria can become resistant to antibacterial drugs by

Aminoglycosides,erythromycin,the tetracyclines,and several other antibacterial drugs affect the function of the bacterial _______,thereby impairing______ in the bacterial cell.

Penicillin,cephalosporins,and several other commonly used antibacterial drugs exert their antibacterial effects by inhibiting the function of ______,which results in impaired production of _________ that are essential for normal membrane structure and function.

Antibacterial drugs work by all of the following mechanisms EXCEPT inhibition of

To limit the development of bacteria that are resistant to drug therapy,it is encouraged that

Beta-lactamase inhibitors such as clavulanate,sulbactam,and tazobactam are typically combined with a specific type of penicillin

Rehabilitation interventions that use ultraviolet irradiation (UV light)should be used cautiously in people taking antibacterial drugs because antibacterial drugs may cause

Certain antibacterial drugs such as trimethoprim and the sulfonamide drugs (e.g.,sulfadiazine,sulfamethoxazole)selectively inhibit the synthesis and function of nucleic acids and certain essential amino acids by impairing the production of ______ in bacterial cells.

Basic Principles of Pharmacology

Pharmacokinetics IDrug Administration,Absorption,and Distribution

Pharmacokinetics II: Drug Elimination

Drug Receptors

General Principles of Central Nervous System Pharmacology

Sedative Hypnotic and Anti-anxiety Agents

Drugs to Treat Affective Disorders Depression and Bipolar Syndrome

Antipsychotic Drugs

Antiepileptic Drugs

Pharmacologic Management of Parkinson Disease

General Anesthetics

Local Anesthetics

Skeletal Muscle Relaxants

Opioid Analgesics

Non-steroidal Anti Inflammatory Drugs

Pharmacologic Management of Rheumatoid Arthritis and Osteoarthritis

Patient Controlled Analgesia

Introduction to Autonomic Pharmacology

Cholinergic Drugs

Adrenergic Drugs

Antihypertensive Drugs

Treatment of Angina Pectoris

Treatment of Cardiac Arrhythmias

Treatment of Congestive Heart Failure

Treatment of Coagulation Disorders and Hyperlipidemia

Respiratory Drugs

Gastrointestinal Drugs

Introduction to Endocrine Pharmacology

Adrenocorticosteroids

Male and Female Hormones

Thyroid and Parathyroid Drugs: Agents Affecting Bone Mineralization

Pancreatic Hormones and the Treatment of Diabetes Mellitus

Treatment of Infections II: Antiviral Drugs

Treatment of Infections III: Antifungal and Antiparasitic Drugs

Cancer Chemotherapy

Immunomodulating Agents

Filters

Aminoglycosides,erythromycin,the tetracyclines,and several other antibacterial drugs affect the function of the bacterial _,thereby impairing in the bacterial cell.

Penicillin,cephalosporins,and several other commonly used antibacterial drugs exert their antibacterial effects by inhibiting the function of ,which results in impaired production of ___ that are essential for normal membrane structure and function.