Question 1

Monoclonal antibodies may be especially effective in treating certain cancers because these drugs

Accepted Answer

A)  create a strong alkyl reaction with the DNA molecule 
B)  directly inhibit the topoisomerase enzyme responsible for DNA synthesis 
C)  are attracted directly to the cancer cell, without an appreciable affect on healthy tissues 
D)  directly inhibit the mitotic apparatus that is responsible for controlling cell division (mitosis) 
E)  none of the above are true 
A)  create a strong alkyl reaction with the DNA molecule 
B)  directly inhibit the topoisomerase enzyme responsible for DNA synthesis 
C)  are attracted directly to the cancer cell, without an appreciable affect on healthy tissues 
D)  directly inhibit the mitotic apparatus that is responsible for controlling cell division (mitosis) 
E)  none of the above are true C

Question 2

Some of the newer cancer chemotherapy agents (e.g.,cytokines)are called biological therapies or biological response modifiers because they

Accepted Answer

A)  form strong alkyl bonds within the DNA of the cancerous cell 
B)  act as false nucleic acid precursors during DNA biosynthesis 
C)  encourage the body's immune system to fight cancerous cells 
D)  encourage the mitotic apparatus to function more effectively 
E)  stimulate the supply of blood and nutrients to the developing tumor 
A)  form strong alkyl bonds within the DNA of the cancerous cell 
B)  act as false nucleic acid precursors during DNA biosynthesis 
C)  encourage the body's immune system to fight cancerous cells 
D)  encourage the mitotic apparatus to function more effectively 
E)  stimulate the supply of blood and nutrients to the developing tumor C

Question 3

Aspirin and similar NSAIDs may help prevent colorectal cancer and other malignancies by inhibiting the production of ______.

Accepted Answer

A)  new blood vessels 
B)  tumor necrosis factor alpha 
C)  interferons 
D)  interleukins 
E)  prostaglandins 
A)  new blood vessels 
B)  tumor necrosis factor alpha 
C)  interferons 
D)  interleukins 
E)  prostaglandins E

Question 4

Which of the following drug categories is not used to treat cancer?

Accepted Answer

A)  alkylating agents 
B)  antimetabolites 
C)  interferons 
D)  drugs that increase mitosis 
E)  endocrines 
A)  alkylating agents 
B)  antimetabolites 
C)  interferons 
D)  drugs that increase mitosis 
E)  endocrines

Question 5

Most anticancer drugs exert severe and potentially toxic side effects because

Accepted Answer

A)  these drugs have a high therapeutic index (TI) 
B)  most of these drugs are not approved by the FDA 
C)  most of these drugs do not discriminate between healthy tissues and cancerous cells 
D)  these drugs all have extremely long half-lives, and tend to accumulate in the body for an extended period of time 
E)  the threshold dose of these drugs is typically much higher than other drugs 
A)  these drugs have a high therapeutic index (TI) 
B)  most of these drugs are not approved by the FDA 
C)  most of these drugs do not discriminate between healthy tissues and cancerous cells 
D)  these drugs all have extremely long half-lives, and tend to accumulate in the body for an extended period of time 
E)  the threshold dose of these drugs is typically much higher than other drugs

Question 6

Anti-cancer drugs are classified as cell-cycle-nonspecific if they exert antineoplastic effects on the cell only when it is in the _______ phase of the cell cycle.

Accepted Answer

A)  G1 
B)  G2 
C)  S 
D)  M 
E)  none of the above are true 
A)  G1 
B)  G2 
C)  S 
D)  M 
E)  none of the above are true

Question 7

A relatively new strategy for treating certain tumors is to prevent the formation of new blood vessels,thus impairing tumor growth by starving the tumor of oxygen and nutrients.Drugs that use this strategy are known as

Accepted Answer

A)  topoisomerase inhibitors 
B)  angiogenesis inhibitors 
C)  aromatase inhibitors 
D)  antimetabolites 
E)  none of the above are true 
A)  topoisomerase inhibitors 
B)  angiogenesis inhibitors 
C)  aromatase inhibitors 
D)  antimetabolites 
E)  none of the above are true

Exam 36: Cancer Chemotherapy

Monoclonal antibodies may be especially effective in treating certain cancers because these drugs

Some of the newer cancer chemotherapy agents (e.g.,cytokines)are called biological therapies or biological response modifiers because they

Aspirin and similar NSAIDs may help prevent colorectal cancer and other malignancies by inhibiting the production of ______.

Which of the following drug categories is not used to treat cancer?

Most anticancer drugs exert severe and potentially toxic side effects because

Anti-cancer drugs are classified as cell-cycle-nonspecific if they exert antineoplastic effects on the cell only when it is in the _______ phase of the cell cycle.

A relatively new strategy for treating certain tumors is to prevent the formation of new blood vessels,thus impairing tumor growth by starving the tumor of oxygen and nutrients.Drugs that use this strategy are known as

Basic Principles of Pharmacology

Pharmacokinetics IDrug Administration,Absorption,and Distribution

Pharmacokinetics II: Drug Elimination

Drug Receptors

General Principles of Central Nervous System Pharmacology

Sedative Hypnotic and Anti-anxiety Agents

Drugs to Treat Affective Disorders Depression and Bipolar Syndrome

Antipsychotic Drugs

Antiepileptic Drugs

Pharmacologic Management of Parkinson Disease

General Anesthetics

Local Anesthetics

Skeletal Muscle Relaxants

Opioid Analgesics

Non-steroidal Anti Inflammatory Drugs

Pharmacologic Management of Rheumatoid Arthritis and Osteoarthritis

Patient Controlled Analgesia

Introduction to Autonomic Pharmacology

Cholinergic Drugs

Adrenergic Drugs

Antihypertensive Drugs

Treatment of Angina Pectoris

Treatment of Cardiac Arrhythmias

Treatment of Congestive Heart Failure

Treatment of Coagulation Disorders and Hyperlipidemia

Respiratory Drugs

Gastrointestinal Drugs

Introduction to Endocrine Pharmacology

Adrenocorticosteroids

Male and Female Hormones

Thyroid and Parathyroid Drugs: Agents Affecting Bone Mineralization

Pancreatic Hormones and the Treatment of Diabetes Mellitus

Treatment of Infections I: Antibacterial Drugs

Treatment of Infections II: Antiviral Drugs

Treatment of Infections III: Antifungal and Antiparasitic Drugs

Immunomodulating Agents

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