Exam 3: Pharmacokinetics II: Drug Elimination

Prolonged administration of therapeutic drugs and other substances (alcohol,nicotine)may enhance the liver's ability to metabolize certain drugs,thus decreasing their therapeutic effect.This process is known as _______

Biotransformation usually results in an altered version of the original compound known as

Drug oxidation occurs when ______ the original compound.

The process of breaking the original drug compound into separate parts is known as

The amount of time required for 50 percent of the drug remaining in the body to be eliminated is known as the

Drug metabolism that occurs when a drug is changed chemically following administration is also known as

Drug metabolism by the liver and other organs typically creates a more ____ compound,thus enabling the compound to be ____ when it reaches the nephrons in the kidney.

Drugs and their metabolites are excreted from the body primarily by

The primary location for drug metabolism (biotransformation)is the

Variations in drug response may occur because of individual differences in the patient's

To calculate drug elimination rates,blood flow to an organ and the fraction of drug removed from the plasma as it passes through the organ are measured to determine drug

Most drugs are metabolized by _____ to the drug molecule,and the enzymes that catalyze these reactions are typically located at the ____ of specific cells.