Question 1

Patients undergoing lithium therapy should be observed for signs of overdose toxicity, including:

Accepted Answer

A)  hyperpyrexia. 
B)  constipation. 
C)  muscle rigidity and fasciculations. 
D)  loquacious speech. 
A)  hyperpyrexia. 
B)  constipation. 
C)  muscle rigidity and fasciculations. 
D)  loquacious speech.

Question 2

Which of the following choices is recommended to counteract the anticholinergic effects of first-generation antipsychotics?

Accepted Answer

A)  Caffeine-containing beverages 
B)  Alcohol-containing mouth rinses 
C)  Sugarless products or artificial saliva 
D)  Sugar-containing candy 
A)  Caffeine-containing beverages 
B)  Alcohol-containing mouth rinses 
C)  Sugarless products or artificial saliva 
D)  Sugar-containing candy

Question 3

Which of the following types of dental medicaments must be administered with caution to patients taking tricyclic antidepressants?

Accepted Answer

A)  Fluoride 
B)  Antibiotics 
C)  Anesthetics 
D)  Analgesics 
A)  Fluoride 
B)  Antibiotics 
C)  Anesthetics 
D)  Analgesics

Question 4

SSRIs tend to produce CNS stimulation rather than CNS depression.

Accepted Answer

A) True 
 B)False

Question 5

Abrupt withdrawal of serotonin norepinephrine reuptake inhibitors (SNRIs)can lead to symptoms of:

Accepted Answer

A)  urinary retention. 
B)  anxiety. 
C)  tachycardia. 
D)  sweating. 
A)  urinary retention. 
B)  anxiety. 
C)  tachycardia. 
D)  sweating.

Question 6

Interaction of monoamine oxidase inhibitors (MAOIs)with many drugs such as amphetamines, and with foods such as wines, cheese, and fish, can precipitate:

Accepted Answer

A)  hair loss. 
B)  hypertensive crisis. 
C)  gout. 
D)  dysgeusia. 
A)  hair loss. 
B)  hypertensive crisis. 
C)  gout. 
D)  dysgeusia.

Question 7

Serotonin norepinephrine reuptake inhibitors (SNRIs): (Select all that apply.)

Accepted Answer

A)  are considered first line therapy for the treatment of depression. 
B)  are considered superior to selective serotonin reuptake inhibitors (SSRIs). 
C)  can induce withdrawal symptoms is abruptly discontinued. 
D)  are antipsychotic agents. 
A)  are considered first line therapy for the treatment of depression. 
B)  are considered superior to selective serotonin reuptake inhibitors (SSRIs). 
C)  can induce withdrawal symptoms is abruptly discontinued. 
D)  are antipsychotic agents.

Question 8

Bupropion is reserved for patients who are not responsive to other agents because of a potential for:

Accepted Answer

A)  cardiac arrhythmias. 
B)  seizures. 
C)  retinopathy. 
D)  glaucoma. 
A)  cardiac arrhythmias. 
B)  seizures. 
C)  retinopathy. 
D)  glaucoma.

Question 9

Which of the following side effects is the most serious peripheral side effect associated with the use of tricyclic antidepressants?

Accepted Answer

A)  Orthostatic hypotension 
B)  Cardiac toxicity 
C)  Urination 
D)  Bradycardia 
A)  Orthostatic hypotension 
B)  Cardiac toxicity 
C)  Urination 
D)  Bradycardia

Question 10

Phenothiazines cause orthostatic hypotension by blocking which receptor?

Accepted Answer

A)  α-Adrenergic 
B)  β-Adrenergic 
C)  Dopamine 
D)  Acetylcholine 
A)  α-Adrenergic 
B)  β-Adrenergic 
C)  Dopamine 
D)  Acetylcholine

Question 11

Force should be exerted to open the patient's mouth if muscle spasm is present as a result of tardive dyskinesia.

Accepted Answer

A) True 
 B)False

Question 12

Which of the following categories of medications has recently been approved for the treatment of bipolar disorder?

Accepted Answer

A)  High-potency first-generation antipsychotics 
B)  Second-generation antipsychotics 
C)  SSRIs 
D)  MAOIs 
A)  High-potency first-generation antipsychotics 
B)  Second-generation antipsychotics 
C)  SSRIs 
D)  MAOIs

Question 13

First-generation antipsychotics are primarily _____ antagonists.

Accepted Answer

A)  acetylcholine 
B)  norepinephrine 
C)  dopamine 
D)  serotonin (5-hydroxytryptamine) 
A)  acetylcholine 
B)  norepinephrine 
C)  dopamine 
D)  serotonin (5-hydroxytryptamine)

Question 14

In general, lower potency first-generation antipsychotic agents such as chlorpromazine (Thorazine)will have more of which of the following effects in contrast to the higher potency first-generation antipsychotic agents such as haloperidol (Haldol): (1)sedation, (2)orthostatic hypotension, (3)autonomic effects, (4)extrapyramidal effects?

Accepted Answer

A)  1, 2, 3, 4 
B)  1, 2, 3 
C)  2, 3, 4 
D)  1, 2 
E)  3, 4 
A)  1, 2, 3, 4 
B)  1, 2, 3 
C)  2, 3, 4 
D)  1, 2 
E)  3, 4

Question 15

Which of the following are anticholinergic effects that may be associated with tricyclic antidepressants?

Accepted Answer

A)  Xerostomia 
B)  Bradycardia 
C)  Urination 
D)  Both a and b 
E)  Both b and c 
A)  Xerostomia 
B)  Bradycardia 
C)  Urination 
D)  Both a and b 
E)  Both b and c

Question 16

Which antidepressant is least likely to cause xerostomia?

Accepted Answer

A)  Bupropion 
B)  Sertraline 
C)  Chlorpromazine 
D)  Amitriptyline 
E)  Trazodone 
A)  Bupropion 
B)  Sertraline 
C)  Chlorpromazine 
D)  Amitriptyline 
E)  Trazodone

Question 17

The type of depression that exhibits alternating periods of depression and excitation have a(n)_____ disorder.

Accepted Answer

A)  endogenous 
B)  exogenous 
C)  manic-depressive 
D)  reactive 
A)  endogenous 
B)  exogenous 
C)  manic-depressive 
D)  reactive

Question 18

Intractable hiccups have been successfully treated with first-generation antipsychotics.

Accepted Answer

A) True 
 B)False

Exam 17: Drugs for the Treatment of Central Nervous System Disorders

Patients undergoing lithium therapy should be observed for signs of overdose toxicity, including:

Which of the following choices is recommended to counteract the anticholinergic effects of first-generation antipsychotics?

Which of the following types of dental medicaments must be administered with caution to patients taking tricyclic antidepressants?

SSRIs tend to produce CNS stimulation rather than CNS depression.

Abrupt withdrawal of serotonin norepinephrine reuptake inhibitors (SNRIs)can lead to symptoms of:

Interaction of monoamine oxidase inhibitors (MAOIs)with many drugs such as amphetamines, and with foods such as wines, cheese, and fish, can precipitate:

Serotonin norepinephrine reuptake inhibitors (SNRIs): (Select all that apply.)

Bupropion is reserved for patients who are not responsive to other agents because of a potential for:

Which of the following side effects is the most serious peripheral side effect associated with the use of tricyclic antidepressants?

Phenothiazines cause orthostatic hypotension by blocking which receptor?

Force should be exerted to open the patient's mouth if muscle spasm is present as a result of tardive dyskinesia.

Which of the following categories of medications has recently been approved for the treatment of bipolar disorder?

First-generation antipsychotics are primarily _____ antagonists.

Which of the following are anticholinergic effects that may be associated with tricyclic antidepressants?

Which antidepressant is least likely to cause xerostomia?

The type of depression that exhibits alternating periods of depression and excitation have a(n)_____ disorder.

Intractable hiccups have been successfully treated with first-generation antipsychotics.

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