Question 1

What route is used to administer the tuberculosis skin test?

Accepted Answer

A)  Intramuscular 
B)  Intradermal 
C)  Intravenous 
D)  Subcutaneous 
A)  Intramuscular 
B)  Intradermal 
C)  Intravenous 
D)  Subcutaneous B

Question 2

Drugs that are weak electrolytes will cross body membranes best when they are (1)nonionized, (2)ionized, (3)polar, (4)nonpolar, (5)lipid soluble, (6)water soluble.

Accepted Answer

A)  1, 3, 5 
B)  1, 3, 6 
C)  1, 4, 5 
D)  1, 4, 6 
E)  2, 4, 5 
A)  1, 3, 5 
B)  1, 3, 6 
C)  1, 4, 5 
D)  1, 4, 6 
E)  2, 4, 5 C

Question 3

The need for an increasingly larger dose of a drug to obtain the same effects as the original dose is:

Accepted Answer

A)  drug dependency. 
B)  insufficiency. 
C)  drug tolerance. 
D)  craving. 
A)  drug dependency. 
B)  insufficiency. 
C)  drug tolerance. 
D)  craving. C

Question 4

Administering a drug of greater potency is better because drugs of greater potency do not require as high a dose.

Accepted Answer

A)  Both parts of the statement are true. 
B)  Both parts of the statement are false. 
C)  The first part of the statement is true; the second part is false. 
D)  The first part of the statement is false; the second part is true. 
A)  Both parts of the statement are true. 
B)  Both parts of the statement are false. 
C)  The first part of the statement is true; the second part is false. 
D)  The first part of the statement is false; the second part is true.

Question 5

Increasing the pH of a solution will cause:

Accepted Answer

A)  a greater percentage of a weak base in the solution to be in the ionized form. 
B)  a greater percentage of a weak acid in the solution to be in the un-ionized form. 
C)  the hydrogen ion concentration to increase. 
D)  a greater percentage of a weak base in the solution to be in the un-ionized form. 
E)  no change in the relative ionization of weak acids or weak bases. 
A)  a greater percentage of a weak base in the solution to be in the ionized form. 
B)  a greater percentage of a weak acid in the solution to be in the un-ionized form. 
C)  the hydrogen ion concentration to increase. 
D)  a greater percentage of a weak base in the solution to be in the un-ionized form. 
E)  no change in the relative ionization of weak acids or weak bases.

Question 6

The movement of a drug from one site in the body to other sites is called:

Accepted Answer

A)  distribution. 
B)  disruption. 
C)  dispersion. 
D)  active transport. 
A)  distribution. 
B)  disruption. 
C)  dispersion. 
D)  active transport.

Question 7

Which of the following processes in the kidney can result in retention of a drug in the body?

Accepted Answer

A)  Glomerular filtration 
B)  Active tubular secretion 
C)  Passive tubular diffusion 
D)  All of the above 
A)  Glomerular filtration 
B)  Active tubular secretion 
C)  Passive tubular diffusion 
D)  All of the above

Question 8

Which of the following choices is the process by which a substance is transported against a concentration gradient?

Accepted Answer

A)  Passive transfer 
B)  Active transport 
C)  Facilitated diffusion 
D)  Filtration 
A)  Passive transfer 
B)  Active transport 
C)  Facilitated diffusion 
D)  Filtration

Question 9

If a drug displays zero-order elimination kinetics:

Accepted Answer

A)  elimination increases as the dose of the drug is increased. 
B)  a constant amount is eliminated per unit time. 
C)  the drug is not eliminated and is retained in the body. 
D)  the elimination of the drug cannot be predicted mathematically. 
A)  elimination increases as the dose of the drug is increased. 
B)  a constant amount is eliminated per unit time. 
C)  the drug is not eliminated and is retained in the body. 
D)  the elimination of the drug cannot be predicted mathematically.

Question 10

Which of the following is not a subject of pharmacokinetics?

Accepted Answer

A)  Physiologic action of drugs 
B)  Metabolism of drugs 
C)  Elimination of drugs 
D)  Absorption of drugs 
A)  Physiologic action of drugs 
B)  Metabolism of drugs 
C)  Elimination of drugs 
D)  Absorption of drugs

Question 11

One dose of a drug is administered that has a half-life of 8 hours. Assuming first-order kinetics, how much time is needed for this drug to be over 96% eliminated from the body?

Accepted Answer

A)  8 hours 
B)  40 hours 
C)  60 hours 
D)  120 hours 
A)  8 hours 
B)  40 hours 
C)  60 hours 
D)  120 hours

Question 12

Enterohepatic circulation of a drug involves the secretion of a metabolized drug into the intestine. If enterohepatic circulation is blocked, the level of the drug in the serum will fall.

Accepted Answer

A)  Both statements are true. 
B)  Both statements are false. 
C)  The first statement is true, the second statement is false. 
D)  The first statement is false, the second statement is true. 
A)  Both statements are true. 
B)  Both statements are false. 
C)  The first statement is true, the second statement is false. 
D)  The first statement is false, the second statement is true.

Question 13

When different drugs compete for the same receptor sites, the drug with the stronger affinity for the receptor will bind to:

Accepted Answer

A)  more receptors than the drug with the weaker affinity. 
B)  fewer receptors than the drug with the weaker affinity. 
C)  all of the available receptors. 
D)  none of the available receptors. 
A)  more receptors than the drug with the weaker affinity. 
B)  fewer receptors than the drug with the weaker affinity. 
C)  all of the available receptors. 
D)  none of the available receptors.

Question 14

What of the following choices is considered the safest, least expensive, and most convenient route for administering drugs?

Accepted Answer

A)  Inhalation 
B)  Rectal 
C)  Oral 
D)  Subcutaneous 
A)  Inhalation 
B)  Rectal 
C)  Oral 
D)  Subcutaneous

Question 15

An enteral route of administration would be:

Accepted Answer

A)  intravenous. 
B)  oral. 
C)  sublingual. 
D)  transdermal. 
A)  intravenous. 
B)  oral. 
C)  sublingual. 
D)  transdermal.

Question 16

Drugs, after undergoing phase I drug metabolism, are more likely to be distributed to fat tissue.

Accepted Answer

A) True 
 B)False

Question 17

Which of the following is true regarding basic principles of drug distribution in the bloodstream?

Accepted Answer

A)  All drugs in the blood are either bound to plasma proteins or free. 
B)  Only the drug that is bound to plasma proteins can exert the pharmacologic effect. 
C)  Only the drug that is bound to plasma proteins can pass across cell membranes. 
D)  The free drug is a reservoir for the drug. 
A)  All drugs in the blood are either bound to plasma proteins or free. 
B)  Only the drug that is bound to plasma proteins can exert the pharmacologic effect. 
C)  Only the drug that is bound to plasma proteins can pass across cell membranes. 
D)  The free drug is a reservoir for the drug.

Question 18

The metabolite formed during metabolism (biotransformation)is usually _____ polar and _____ lipid soluble than its parent compound.

Accepted Answer

A)  more; more 
B)  more; less 
C)  less; more 
D)  less; less 
A)  more; more 
B)  more; less 
C)  less; more 
D)  less; less

Question 19

Which organ is involved in the first-pass effect after oral administration of a drug?

Accepted Answer

A)  Kidney 
B)  Lungs 
C)  Liver 
D)  Spleen 
A)  Kidney 
B)  Lungs 
C)  Liver 
D)  Spleen

Question 20

Application of a transdermal patch is an example of parenteral administration because the drug is delivered in a manner that bypasses the gastrointestinal tract.

Accepted Answer

A)  Both parts of the statements are true. 
B)  Both parts of the statements are false. 
C)  The first part of the statement is true; the second part is false. 
D)  The first part of the statement is false; the second part is true. 
A)  Both parts of the statements are true. 
B)  Both parts of the statements are false. 
C)  The first part of the statement is true; the second part is false. 
D)  The first part of the statement is false; the second part is true.

Exam 2: Drug Action and Handling

What route is used to administer the tuberculosis skin test?

Drugs that are weak electrolytes will cross body membranes best when they are (1)nonionized, (2)ionized, (3)polar, (4)nonpolar, (5)lipid soluble, (6)water soluble.

The need for an increasingly larger dose of a drug to obtain the same effects as the original dose is:

Administering a drug of greater potency is better because drugs of greater potency do not require as high a dose.

Increasing the pH of a solution will cause:

The movement of a drug from one site in the body to other sites is called:

Which of the following processes in the kidney can result in retention of a drug in the body?

Which of the following choices is the process by which a substance is transported against a concentration gradient?

If a drug displays zero-order elimination kinetics:

Which of the following is not a subject of pharmacokinetics?

One dose of a drug is administered that has a half-life of 8 hours. Assuming first-order kinetics, how much time is needed for this drug to be over 96% eliminated from the body?

Enterohepatic circulation of a drug involves the secretion of a metabolized drug into the intestine. If enterohepatic circulation is blocked, the level of the drug in the serum will fall.

When different drugs compete for the same receptor sites, the drug with the stronger affinity for the receptor will bind to:

What of the following choices is considered the safest, least expensive, and most convenient route for administering drugs?

An enteral route of administration would be:

Drugs, after undergoing phase I drug metabolism, are more likely to be distributed to fat tissue.

Which of the following is true regarding basic principles of drug distribution in the bloodstream?

The metabolite formed during metabolism (biotransformation)is usually _____ polar and _____ lipid soluble than its parent compound.

Which organ is involved in the first-pass effect after oral administration of a drug?

Application of a transdermal patch is an example of parenteral administration because the drug is delivered in a manner that bypasses the gastrointestinal tract.

Information Sources, Regulatory Agencies, Drug Legislation, and Prescription Writing

Adverse Reactions

Autonomic Drugs

Nonopioid (Nonnarcotic)Analgesics

Opioid (Narcotic)Analgesics and Antagonists

Antiinfective Agents

Antifungal and Antiviral Agents

Local Anesthetics

General Anesthetics

Antianxiety Agents

Oral Conditions and Their Treatment

Hygiene-Related Oral Disorders

Drugs for the Treatment of Cardiovascular Disease

Drugs for the Treatment of Gastrointestinal Disorders

Drugs for the Treatment of Seizure Disorders

Drugs for the Treatment of Central Nervous System Disorders

Adrenocorticosteroids

Drugs for the Treatment of Respiratory Disorders

Drugs for the Treatment of Allergic Rhinitis

Drugs for the Treatment of Diabetes Mellitus

Drugs for the Treatment of Other Endocrine Disorders

Antineoplastic Drugs

Emergency Drugs

Pregnancy and Breast Feeding

Drug Abuse

Natural/Herbal Products and Dietary Supplements

Filters

The metabolite formed during metabolism (biotransformation)is usually _ polar and _ lipid soluble than its parent compound.