Question 1

When a drug has affinity for a receptor and produces no effect, it is called a(n):

Accepted Answer

A)  agonist. 
B)  competitive antagonist. 
C)  competitive agonist. 
D)  physiologic agonist. 
A)  agonist. 
B)  competitive antagonist. 
C)  competitive agonist. 
D)  physiologic agonist.

Question 2

The route of administration of a drug affects both the onset and duration of response.

Accepted Answer

A) True 
 B)False

Question 3

Advantages of oral administration of a drug include all the following except:

Accepted Answer

A)  large surface area for drug absorption. 
B)  many different dose forms that may be administered orally. 
C)  more predictable response than intravenous administration. 
D)  the simplest way to introduce a drug into the body. 
A)  large surface area for drug absorption. 
B)  many different dose forms that may be administered orally. 
C)  more predictable response than intravenous administration. 
D)  the simplest way to introduce a drug into the body.

Question 4

If redistribution occurs between specific sites and nonspecific sites, a drug's action will be:

Accepted Answer

A)  prolonged. 
B)  extended. 
C)  decreased. 
D)  terminated. 
A)  prolonged. 
B)  extended. 
C)  decreased. 
D)  terminated.

Question 5

The _____ is the most common site for biotransformation.

Accepted Answer

A)  kidney 
B)  blood plasma 
C)  liver 
D)  small intestine 
A)  kidney 
B)  blood plasma 
C)  liver 
D)  small intestine

Question 6

The half-life of a drug is most related to its:

Accepted Answer

A)  onset. 
B)  duration. 
C)  safety. 
D)  time to peak concentration. 
A)  onset. 
B)  duration. 
C)  safety. 
D)  time to peak concentration.

Question 7

Which of the following routes of drug administration produces the most rapid drug response?

Accepted Answer

A)  Intravenous 
B)  Intramuscular 
C)  Subcutaneous 
D)  Intradermal 
A)  Intravenous 
B)  Intramuscular 
C)  Subcutaneous 
D)  Intradermal

Question 8

Which of the following statements is true concerning the mechanism of action of drugs?

Accepted Answer

A)  Drugs are capable of imparting a new function to the organism. 
B)  Drugs either produce the same action as an exogenous agent or block the action of an exogenous agent. 
C)  Drugs either produce the same action as an exogenous agent or block the action of an endogenous agent. 
D)  Drugs either produce the same action as an endogenous agent or block the action of an endogenous agent. 
A)  Drugs are capable of imparting a new function to the organism. 
B)  Drugs either produce the same action as an exogenous agent or block the action of an exogenous agent. 
C)  Drugs either produce the same action as an exogenous agent or block the action of an endogenous agent. 
D)  Drugs either produce the same action as an endogenous agent or block the action of an endogenous agent.

Question 9

A prodrug is an inactive drug compound that becomes transformed into an active drug compound.

Accepted Answer

A) True 
 B)False

Question 10

All of the following choices are true with regard to cytochrome P-450 hepatic microsomal enzymes except that they:

Accepted Answer

A)  can be induced to speed up drug metabolism. 
B)  can be inhibited to slow down drug metabolism. 
C)  exist as numerous isoenzymes. 
D)  inactivate drugs through conjugation reactions. 
A)  can be induced to speed up drug metabolism. 
B)  can be inhibited to slow down drug metabolism. 
C)  exist as numerous isoenzymes. 
D)  inactivate drugs through conjugation reactions.

Question 11

A patient's perception that a pill without active ingredients is having a pharmacologic effect is termed:

Accepted Answer

A)  tachyphylaxis. 
B)  hypersensitivity. 
C)  neurosis. 
D)  compliance. 
E)  placebo effect. 
A)  tachyphylaxis. 
B)  hypersensitivity. 
C)  neurosis. 
D)  compliance. 
E)  placebo effect.

Question 12

A drug is defined as a biologically active substance that can modify:

Accepted Answer

A)  the environment. 
B)  the pH of tissue. 
C)  cellular function. 
D)  immune response. 
A)  the environment. 
B)  the pH of tissue. 
C)  cellular function. 
D)  immune response.

Question 13

Which of the following is (are)true when tubular urine is more acid?

Accepted Answer

A)  Weak acids are excreted more rapidly. 
B)  Weak bases are excreted more rapidly. 
C)  Weak acids are excreted more slowly. 
D)  Both a and b are true. 
E)  Both b and c are true. 
A)  Weak acids are excreted more rapidly. 
B)  Weak bases are excreted more rapidly. 
C)  Weak acids are excreted more slowly. 
D)  Both a and b are true. 
E)  Both b and c are true.

Question 14

What type of administration involves the injection of solutions into the spinal subarachnoid space?

Accepted Answer

A)  Intrathecal route 
B)  Intraperitoneal route 
C)  Intravenous route 
D)  Intradermal route 
A)  Intrathecal route 
B)  Intraperitoneal route 
C)  Intravenous route 
D)  Intradermal route

Question 15

If a drug is a weak base that is excreted via the kidneys, then acidifying the urine will enhance its excretion.

Accepted Answer

A) True 
 B)False

Question 16

Which of the following statements is true regarding the therapeutic index (TI)of a drug?

Accepted Answer

A)  A drug with a large TI is more dangerous than a drug with a small TI. 
B)  The formula for TI is ED₅₀/LD₅₀ . 
C)  ED₅₀ is 50% of the effective clinical dose. 
D)  TI is the ratio of the median lethal dose to the median effective dose. 
A)  A drug with a large TI is more dangerous than a drug with a small TI. 
B)  The formula for TI is ED₅₀/LD₅₀ . 
C)  ED₅₀ is 50% of the effective clinical dose. 
D)  TI is the ratio of the median lethal dose to the median effective dose.

Question 17

Which of the following reactions is considered to be in the category of phase II drug metabolism?

Accepted Answer

A)  Conjugation 
B)  Reduction 
C)  Hydrolysis 
D)  Oxidation 
A)  Conjugation 
B)  Reduction 
C)  Hydrolysis 
D)  Oxidation

Question 18

If one dose of a drug is administered and the drug's half-life in the body is 3 hours, what percentage of the drug would be left after four half-lives?

Accepted Answer

A)  50% 
B)  6.25% 
C)  2% 
D)  Insufficient information to determine 
A)  50% 
B)  6.25% 
C)  2% 
D)  Insufficient information to determine

Question 19

In comparing two drugs, the dose-response curve for the drug that is more efficacious would:

Accepted Answer

A)  be closer to the y axis. 
B)  be farther from the y axis. 
C)  have a greater curve height. 
D)  have a higher median effective dose (ED₅₀). 
A)  be closer to the y axis. 
B)  be farther from the y axis. 
C)  have a greater curve height. 
D)  have a higher median effective dose (ED₅₀).

Question 20

Which of the following statements is (are)true concerning passage across body membranes?

Accepted Answer

A)  The membrane lipids make the membrane relatively permeable to ions and polar molecules. 
B)  The lipid molecules orient themselves so that they form a fluid bimolecular leaflet structure with the hydrophobic ends of the molecules shielded from the surrounding aqueous environment. 
C)  Membrane carbohydrates make up the structural components of the membrane and help move the molecules across the membrane during the transport process. 
D)  Both a and b are true. 
E)  Both b and c are true. 
A)  The membrane lipids make the membrane relatively permeable to ions and polar molecules. 
B)  The lipid molecules orient themselves so that they form a fluid bimolecular leaflet structure with the hydrophobic ends of the molecules shielded from the surrounding aqueous environment. 
C)  Membrane carbohydrates make up the structural components of the membrane and help move the molecules across the membrane during the transport process. 
D)  Both a and b are true. 
E)  Both b and c are true.

Exam 2: Drug Action and Handling

When a drug has affinity for a receptor and produces no effect, it is called a(n):

The route of administration of a drug affects both the onset and duration of response.

Advantages of oral administration of a drug include all the following except:

If redistribution occurs between specific sites and nonspecific sites, a drug's action will be:

The _____ is the most common site for biotransformation.

The half-life of a drug is most related to its:

Which of the following routes of drug administration produces the most rapid drug response?

Which of the following statements is true concerning the mechanism of action of drugs?

A prodrug is an inactive drug compound that becomes transformed into an active drug compound.

All of the following choices are true with regard to cytochrome P-450 hepatic microsomal enzymes except that they:

A patient's perception that a pill without active ingredients is having a pharmacologic effect is termed:

A drug is defined as a biologically active substance that can modify:

Which of the following is (are)true when tubular urine is more acid?

What type of administration involves the injection of solutions into the spinal subarachnoid space?

If a drug is a weak base that is excreted via the kidneys, then acidifying the urine will enhance its excretion.

Which of the following statements is true regarding the therapeutic index (TI)of a drug?

Which of the following reactions is considered to be in the category of phase II drug metabolism?

If one dose of a drug is administered and the drug's half-life in the body is 3 hours, what percentage of the drug would be left after four half-lives?

In comparing two drugs, the dose-response curve for the drug that is more efficacious would:

Which of the following statements is (are)true concerning passage across body membranes?

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