Question 1

The following statements are true of ketoconazole except which one?

Accepted Answer

A)  Ketoconazole is an imidazole that is used in dentistry. 
B)  Hepatoxicity subsequent to the administration of ketoconazole is thought to be an idiosyncratic reaction. 
C)  Ketoconazole has a masculinizing effect by increasing testosterone levels. 
D)  At least 2 hours should pass between the ingestion of an antacid and the administration of ketoconazole. 
E)  Ketoconazole is available as a cream. 
A)  Ketoconazole is an imidazole that is used in dentistry. 
B)  Hepatoxicity subsequent to the administration of ketoconazole is thought to be an idiosyncratic reaction. 
C)  Ketoconazole has a masculinizing effect by increasing testosterone levels. 
D)  At least 2 hours should pass between the ingestion of an antacid and the administration of ketoconazole. 
E)  Ketoconazole is available as a cream.

Question 2

All of the following are antifungal agents that are useful in dentistry except:

Accepted Answer

A)  miconazole. 
B)  docosanol. 
C)  clotrimazole. 
D)  ketoconazole. 
A)  miconazole. 
B)  docosanol. 
C)  clotrimazole. 
D)  ketoconazole.

Question 3

Most antiviral agents are protein synthesis inhibitors.

Accepted Answer

A) True 
 B)False

Question 4

Topical acyclovir:

Accepted Answer

A)  will prevent the transmission of herpes labialis. 
B)  has been effective in the treatment of herpes labialis infections in nonimmunocompromised patients. 
C)  does not prevent the recurrence of herpes labialis. 
D)  Both a and b are correct. 
E)  Both b and c are correct. 
A)  will prevent the transmission of herpes labialis. 
B)  has been effective in the treatment of herpes labialis infections in nonimmunocompromised patients. 
C)  does not prevent the recurrence of herpes labialis. 
D)  Both a and b are correct. 
E)  Both b and c are correct.

Question 5

A person with hepatitis _____ is most likely to develop chronic hepatitis.

Accepted Answer

A)  A 
B)  B 
C)  C 
D)  D 
A)  A 
B)  B 
C)  C 
D)  D

Question 6

Viruses are difficult to treat because they cooperate with the host's cells.

Accepted Answer

A)  Both parts of the statement are true. 
B)  Both parts of the statement are false. 
C)  The first part of the statement is true; the second part is false. 
D)  The first part of the statement is false; the second part is true. 
A)  Both parts of the statement are true. 
B)  Both parts of the statement are false. 
C)  The first part of the statement is true; the second part is false. 
D)  The first part of the statement is false; the second part is true.

Question 7

Which of the following is true of acyclovir?

Accepted Answer

A)  It works by inhibiting replication of deoxyribonucleic acid (DN
A) . 
B)  It should be taken on an empty stomach because food affects the drug's absorption. 
C)  The antiviral action of acyclovir includes herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2), but it is not effective against varicella-zoster virus or Epstein-Barr virus. 
D)  The most common adverse effects associated with oral acyclovir are anorexia and a funny taste in the mouth. 
A)  It works by inhibiting replication of deoxyribonucleic acid (DN
A) . 
B)  It should be taken on an empty stomach because food affects the drug's absorption. 
C)  The antiviral action of acyclovir includes herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2), but it is not effective against varicella-zoster virus or Epstein-Barr virus. 
D)  The most common adverse effects associated with oral acyclovir are anorexia and a funny taste in the mouth.

Question 8

Nystatin is used for both the treatment and the prevention of _____ in susceptible cases.

Accepted Answer

A)  blastomycosis 
B)  histoplasmosis 
C)  oral candidiasis 
D)  tinea 
A)  blastomycosis 
B)  histoplasmosis 
C)  oral candidiasis 
D)  tinea

Question 9

The most serious adverse reaction associated with ketoconazole is:

Accepted Answer

A)  tachycardia. 
B)  hepatotoxicity. 
C)  hypotension. 
D)  achlorhydria. 
A)  tachycardia. 
B)  hepatotoxicity. 
C)  hypotension. 
D)  achlorhydria.

Question 10

Thrush is:

Accepted Answer

A)  an allergic reaction. 
B)  an idiosyncrasy. 
C)  oropharyngeal candidiasis. 
D)  a serious systemic fungal infection. 
A)  an allergic reaction. 
B)  an idiosyncrasy. 
C)  oropharyngeal candidiasis. 
D)  a serious systemic fungal infection.

Question 11

Which of the following antifungal agents is produced by Streptomyces noursei?

Accepted Answer

A)  Fluconazole 
B)  Clotrimazole 
C)  Ketoconazole 
D)  Nystatin 
A)  Fluconazole 
B)  Clotrimazole 
C)  Ketoconazole 
D)  Nystatin

Question 12

Which of the following is a synthetic antifungal agent available in the form of a slowly dissolving, sugar-containing lozenge for oral use?

Accepted Answer

A)  Clotrimazole 
B)  Ketoconazole 
C)  Fluconazole 
D)  Nystatin 
A)  Clotrimazole 
B)  Ketoconazole 
C)  Fluconazole 
D)  Nystatin

Question 13

Which of the following agents has poor oral absorption?

Accepted Answer

A)  Nystatin 
B)  Itraconazole 
C)  Terbinafine 
D)  Griseofulvin 
A)  Nystatin 
B)  Itraconazole 
C)  Terbinafine 
D)  Griseofulvin

Question 14

Which of the following is used prophylactically against candidiasis in immunocompromised patients or for the treatment of candidal infections that do not respond to other agents?

Accepted Answer

A)  Nystatin 
B)  Ketoconazole 
C)  Fluconazole 
D)  Clotrimazole 
A)  Nystatin 
B)  Ketoconazole 
C)  Fluconazole 
D)  Clotrimazole

Question 15

Which of the following groups of drugs used to treat HIV can interfere with the action of the HIV-infected cells?

Accepted Answer

A)  Nucleoside reverse transcriptase inhibitors 
B)  Nonnucleoside reverse transcriptase inhibitors 
C)  Protease inhibitors 
D)  Both a and b 
E)  Both b and c 
A)  Nucleoside reverse transcriptase inhibitors 
B)  Nonnucleoside reverse transcriptase inhibitors 
C)  Protease inhibitors 
D)  Both a and b 
E)  Both b and c

Question 16

The most frequent adverse reaction(s)associated with ketoconazole is (are):

Accepted Answer

A)  diarrhea. 
B)  nausea and vomiting. 
C)  xerostomia. 
D)  premature ventricular contractions. 
A)  diarrhea. 
B)  nausea and vomiting. 
C)  xerostomia. 
D)  premature ventricular contractions.

Question 17

The most common FDA-approved use of interferons is for the treatment of which of the following? (Select all that apply.)

Accepted Answer

A)  Hepatitis B 
B)  Hepatitis C 
C)  Multiple sclerosis 
D)  Emphysema 
E)  Sarcoidosis 
A)  Hepatitis B 
B)  Hepatitis C 
C)  Multiple sclerosis 
D)  Emphysema 
E)  Sarcoidosis

Question 18

Ketoconazole should not be used with _____ because it could reduce the absorption of ketoconazole.

Accepted Answer

A)  penicillin V 
B)  metronidazole 
C)  anticholinergic agents 
D)  acyclovir 
A)  penicillin V 
B)  metronidazole 
C)  anticholinergic agents 
D)  acyclovir

Exam 8: Antifungal and Antiviral Agents

The following statements are true of ketoconazole except which one?

All of the following are antifungal agents that are useful in dentistry except:

Most antiviral agents are protein synthesis inhibitors.

Topical acyclovir:

A person with hepatitis _____ is most likely to develop chronic hepatitis.

Viruses are difficult to treat because they cooperate with the host's cells.

Which of the following is true of acyclovir?

Nystatin is used for both the treatment and the prevention of _____ in susceptible cases.

The most serious adverse reaction associated with ketoconazole is:

Thrush is:

Which of the following antifungal agents is produced by Streptomyces noursei?

Which of the following is a synthetic antifungal agent available in the form of a slowly dissolving, sugar-containing lozenge for oral use?

Which of the following agents has poor oral absorption?

Which of the following is used prophylactically against candidiasis in immunocompromised patients or for the treatment of candidal infections that do not respond to other agents?

Which of the following groups of drugs used to treat HIV can interfere with the action of the HIV-infected cells?

The most frequent adverse reaction(s)associated with ketoconazole is (are):

The most common FDA-approved use of interferons is for the treatment of which of the following? (Select all that apply.)

Ketoconazole should not be used with _____ because it could reduce the absorption of ketoconazole.

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