Question 1

A patient presents with loss of reflexes,foot drop and ataxia.The drugs most likely to cause these problems are the _______________.

Accepted Answer

A) vinca alkaloids 
B) antimetabolites 
C) alkylating agents 
D) topoisomerases inhibitors 
A) vinca alkaloids 
B) antimetabolites 
C) alkylating agents 
D) topoisomerases inhibitors A

Question 2

A patient receiving a transplant develops an immune response to the transplant which intends to reject the foreign organ.Among the many immune factors involved in this response,the most important one seems to be _______________.

Accepted Answer

A) T cells 
B) B cells 
C) interferons 
D) immunoglobulins 
A) T cells 
B) B cells 
C) interferons 
D) immunoglobulins A

Question 3

Cancer chemotherapy while reducing primary cancers can promote the later occurrence of secondary cancers.Which of the following anti-cancer drug classes are mostly associated with a secondary cancer?

Accepted Answer

A) Alkylating agents 
B) Antimetabolites 
C) Tubulin binding drugs 
D) All of the above 
A) Alkylating agents 
B) Antimetabolites 
C) Tubulin binding drugs 
D) All of the above A

Question 4

A patient on cancer chemotherapy shows a suppressed blood cell profile.He might be treated with _______________.

Accepted Answer

A) epoetin to increase white blood cell 
B) filgrastim to stimulate platelets 
C) sargramostim to stimulate white blood cells 
D) All of the above 
A) epoetin to increase white blood cell 
B) filgrastim to stimulate platelets 
C) sargramostim to stimulate white blood cells 
D) All of the above

Question 5

Which of the following therapeutic interventions would you most likely be using with a patient taking a tubulin-binding agent for bladder cancer?

Accepted Answer

A) Measurement of the VO₂mₐₓ on a treadmill 
B) Whirlpool 
C) Extension splinting of the wrist 
D) Ultrasound to the knee 
A) Measurement of the VO₂mₐₓ on a treadmill 
B) Whirlpool 
C) Extension splinting of the wrist 
D) Ultrasound to the knee

Question 6

Adverse reactions to the treatment with cytotoxic drugs are mostly seen in healthy cells which _______________.

Accepted Answer

A) are closest to the tumor cells 
B) divide rapidly 
C) have a large blood vessel supply 
D) are largest in the body 
A) are closest to the tumor cells 
B) divide rapidly 
C) have a large blood vessel supply 
D) are largest in the body

Question 7

The effects of exercise on the outcome of chemotherapy have not been rigorously studied but some general conclusions can be drawn.Which one of the following is one of these conclusions?

Accepted Answer

A) The effect of exercise seems to depend strongly on the drugs used 
B) The effect depends on the status of the patient 
C) The effect is independent of the intensity of the exercise 
D) The effect depends on the type of exercise 
A) The effect of exercise seems to depend strongly on the drugs used 
B) The effect depends on the status of the patient 
C) The effect is independent of the intensity of the exercise 
D) The effect depends on the type of exercise

Question 8

Cytotoxic antimetabolites _______________.

Accepted Answer

A) interfere with the synthesis of DNA bases 
B) are known to cause cardiac toxicity 
C) include leucovorin as the most efficacious drug 
D) are used for tumors with a slow growth rate 
A) interfere with the synthesis of DNA bases 
B) are known to cause cardiac toxicity 
C) include leucovorin as the most efficacious drug 
D) are used for tumors with a slow growth rate

Question 9

The tubulin-binding drugs _______________.

Accepted Answer

A) are cell cycle unspecific 
B) interfere with the synthesis of DNA strands 
C) bind to the protein tubulin 
D) are especially useful for hormone sensitive tumors 
A) are cell cycle unspecific 
B) interfere with the synthesis of DNA strands 
C) bind to the protein tubulin 
D) are especially useful for hormone sensitive tumors

Question 10

A patient tells you that his urine looks red after starting cancer chemotherapy.This is most likely caused by _______________.

Accepted Answer

A) doxorubicin 
B) methotrexate 
C) cyclophosphamide 
D) All of the above 
A) doxorubicin 
B) methotrexate 
C) cyclophosphamide 
D) All of the above

Question 11

Late complications of cancer therapy include _________.

Accepted Answer

A) alopecia 
B) GI upset 
C) secondary cancers 
D) bone marrow suppression 
A) alopecia 
B) GI upset 
C) secondary cancers 
D) bone marrow suppression

Question 12

Combination drug therapy is based on the principle that all drugs must _______________.

Accepted Answer

A) reach the cancer target 
B) have different modes of therapeutic action 
C) show different toxic reactions 
D) All of the above 
A) reach the cancer target 
B) have different modes of therapeutic action 
C) show different toxic reactions 
D) All of the above

Question 13

Resistance to cytotoxic drug treatment can occur when cancer cells _______________.

Accepted Answer

A) are exposed to one instead of multiple drugs 
B) develop mechanisms to quickly expel the drug from their cells 
C) increase DNA repair mechanisms 
D) All of the above 
A) are exposed to one instead of multiple drugs 
B) develop mechanisms to quickly expel the drug from their cells 
C) increase DNA repair mechanisms 
D) All of the above

Question 14

A patient on cancer chemotherapy will unfortunately experience a number of mild to severe adverse reactions.Some of them can be treated such as _______________.

Accepted Answer

A) nausea with anti-adrenergic drugs 
B) diarrhea with opioids 
C) hypersensitivity reactions with antibiotics 
D) bone pain with bisphosphonates 
A) nausea with anti-adrenergic drugs 
B) diarrhea with opioids 
C) hypersensitivity reactions with antibiotics 
D) bone pain with bisphosphonates

Question 15

Monoclonal antibodies _______________.

Accepted Answer

A) are now used solely for the treatment of leukemias 
B) can easily be recognized since they end in -cab 
C) have more selective actions 
D) show a large number of adverse reactions 
A) are now used solely for the treatment of leukemias 
B) can easily be recognized since they end in -cab 
C) have more selective actions 
D) show a large number of adverse reactions

Question 16

A patient with a transplant is treated with an immunosuppressant drug.to help reduce the risk of _______________.

Accepted Answer

A) infections 
B) hepatotoxicity 
C) nephrotoxicity 
D) neurotoxicity 
A) infections 
B) hepatotoxicity 
C) nephrotoxicity 
D) neurotoxicity

Question 17

Cytotoxic drugs _______________.

Accepted Answer

A) act on all phases of the cell cycle 
B) will kill a certain fraction of the growing tumor cells 
C) can kill all tumor cells if given in combination 
D) are more effective in slow growing than in fast growing tumors 
A) act on all phases of the cell cycle 
B) will kill a certain fraction of the growing tumor cells 
C) can kill all tumor cells if given in combination 
D) are more effective in slow growing than in fast growing tumors

Question 18

Alkylating agents interfere with DNA function or synthesis by _______________.

Accepted Answer

A) cross-linking DNA strands 
B) alkylating and inhibiting DNA synthesizing enzymes 
C) alkylating purine bases forming "false" bases 
D) interfering with RNA synthesis 
A) cross-linking DNA strands 
B) alkylating and inhibiting DNA synthesizing enzymes 
C) alkylating purine bases forming "false" bases 
D) interfering with RNA synthesis

Question 19

Choice of a cytotoxic drug depends mostly on_______________.

Accepted Answer

A) the tissue of cancer origin 
B) the age of the patient 
C) the size of the tumor 
D) the growth of the tumor 
A) the tissue of cancer origin 
B) the age of the patient 
C) the size of the tumor 
D) the growth of the tumor

Question 20

The occurrence of secondary cancers after treatment with anticancer drugs _______________.

Accepted Answer

A) is greatest in young individuals 
B) occurs mostly after treatment of breast cancer 
C) occurs between 20-40 years after primary therapy 
D) occurs more often if chemotherapy was combined with radiation 
A) is greatest in young individuals 
B) occurs mostly after treatment of breast cancer 
C) occurs between 20-40 years after primary therapy 
D) occurs more often if chemotherapy was combined with radiation

Exam 22: Cytotoxic Agents and Immune Modulation

A patient presents with loss of reflexes,foot drop and ataxia.The drugs most likely to cause these problems are the _______________.

A patient receiving a transplant develops an immune response to the transplant which intends to reject the foreign organ.Among the many immune factors involved in this response,the most important one seems to be _______________.

Cancer chemotherapy while reducing primary cancers can promote the later occurrence of secondary cancers.Which of the following anti-cancer drug classes are mostly associated with a secondary cancer?

A patient on cancer chemotherapy shows a suppressed blood cell profile.He might be treated with _______________.

Which of the following therapeutic interventions would you most likely be using with a patient taking a tubulin-binding agent for bladder cancer?

Adverse reactions to the treatment with cytotoxic drugs are mostly seen in healthy cells which _______________.

The effects of exercise on the outcome of chemotherapy have not been rigorously studied but some general conclusions can be drawn.Which one of the following is one of these conclusions?

Cytotoxic antimetabolites _______________.

The tubulin-binding drugs _______________.

A patient tells you that his urine looks red after starting cancer chemotherapy.This is most likely caused by _______________.

Late complications of cancer therapy include _________.

Combination drug therapy is based on the principle that all drugs must _______________.

Resistance to cytotoxic drug treatment can occur when cancer cells _______________.

A patient on cancer chemotherapy will unfortunately experience a number of mild to severe adverse reactions.Some of them can be treated such as _______________.

Monoclonal antibodies _______________.

A patient with a transplant is treated with an immunosuppressant drug.to help reduce the risk of _______________.

Cytotoxic drugs _______________.

Alkylating agents interfere with DNA function or synthesis by _______________.

Choice of a cytotoxic drug depends mostly on_______________.

The occurrence of secondary cancers after treatment with anticancer drugs _______________.

Introduction

Pharmacodynamics: Mechanism of Action

Pharmacokinetics and Drug Dosing

Adverse Drug Reactions

Drugs Acting on the Autonomic Nervous System

Antihypertensive

Drug Therapy of Coronary Atherosclerosis and Its Repercussions

Drug Therapy for Congestive Heart Failure and Cardiac Arrhythmias

Drug Therapy for Pulmonary Disorders

Anesthetic Agents

Drugs for the Treatment of Pain and Inflammation

Drug Treatment for Arthritis-Related Conditions

Selective Topics in Endocrine Pharmacology

Drug Treatment for Osteoporosis and Diabetes

Drugs for Epilepsy and Attention Deficit/Hyperactivity Disorder

Antispasticity Medications and Skeletal Muscle Relaxants

Pharmacologic Management of Degenerative Neurologic Disorders

Drug Treatment for Depression and Anxiety

Drug Treatment for Schizophrenia and Bipolar Illness

Antimicrobial Agents

Antiviral Agents and Selected Drugs for Fungal Infections

Drugs for Gastrointestinal Disorders

Vitamins and Minerals

Topical Drugs and Treatments Used in Wound Management

Complementary and Alternative Medicine in Pharmacology

Drugs of Abuse: Anabolic Steroids and Other Doping Agents

Filters