Question 1

Which one of the following is associated with the exogenous intake of a steroid?

Accepted Answer

A) Lowering of blood pressure 
B) Hypoglycemia 
C) Immune suppression 
D) Strengthening of connective tissue 
A) Lowering of blood pressure 
B) Hypoglycemia 
C) Immune suppression 
D) Strengthening of connective tissue C

Question 2

Which one of the following statements is false?

Accepted Answer

A) Iodide at large doses can prevent its uptake into the thyroid gland. 
B) The secretion of the thyroid stimulating hormone or TSH from the pituitary gland increases thyroid hormone production. 
C) Hyperthyroidism manifests as tachycardia, excitation, heat intolerance, tremor, exophthalmos and weight loss. 
D) Propylthiouracil inhibits the synthesis of the thyroid hormones T4 and T3. 
A) Iodide at large doses can prevent its uptake into the thyroid gland. 
B) The secretion of the thyroid stimulating hormone or TSH from the pituitary gland increases thyroid hormone production. 
C) Hyperthyroidism manifests as tachycardia, excitation, heat intolerance, tremor, exophthalmos and weight loss. 
D) Propylthiouracil inhibits the synthesis of the thyroid hormones T4 and T3. B

Question 3

The most commonly used drugs in the treatment of acromegaly simulate which of the following hormones?

Accepted Answer

A) Growth hormone 
B) ACTH 
C) SST 
D) Prolactin 
A) Growth hormone 
B) ACTH 
C) SST 
D) Prolactin C

Question 4

Which of the following drugs would not be used to treat a thyroid storm?

Accepted Answer

A) Beta-blockers to reduce heart rate 
B) Alpha-blockers to reduce hypertension 
C) Large doses of iodide to prevent further iodide uptake 
D) Propylthiouracil to decrease thyroid hormone formation 
A) Beta-blockers to reduce heart rate 
B) Alpha-blockers to reduce hypertension 
C) Large doses of iodide to prevent further iodide uptake 
D) Propylthiouracil to decrease thyroid hormone formation

Question 5

You are seeing a patient in therapy who is on replacement therapy for hypothyroidism.Which one of the following responses or observations indicates that this patient's level of thyroid hormone may be too elevated?

Accepted Answer

A) Heat intolerance during aquatic therapy 
B) Cold intolerance with an ice pack 
C) Dry, flaky skin noted during a back massage 
D) Bradycardia during a treadmill test 
A) Heat intolerance during aquatic therapy 
B) Cold intolerance with an ice pack 
C) Dry, flaky skin noted during a back massage 
D) Bradycardia during a treadmill test

Question 6

Which of the following statements is correct?

Accepted Answer

A) ACTH injections will causes a release of cortisol in Addison's disease. 
B) A deficiency of the release of vasopressin can be treated with prolactin. 
C) Growth hormone injections to adults without exercise have no significant effect on muscle strength. 
D) All of the above 
A) ACTH injections will causes a release of cortisol in Addison's disease. 
B) A deficiency of the release of vasopressin can be treated with prolactin. 
C) Growth hormone injections to adults without exercise have no significant effect on muscle strength. 
D) All of the above

Question 7

Major side effects of oral contraceptives are ________________.

Accepted Answer

A) deep vein thrombosis 
B) ischemic stroke 
C) myocardial infarction 
D) All of the above 
A) deep vein thrombosis 
B) ischemic stroke 
C) myocardial infarction 
D) All of the above

Question 8

Excessive glucocorticoid secretion ________________.

Accepted Answer

A) occurs in Cushing's syndrome 
B) leads to bone strengthening 
C) enlarges extremities 
D) is treated with prednisone to block cortisol release 
A) occurs in Cushing's syndrome 
B) leads to bone strengthening 
C) enlarges extremities 
D) is treated with prednisone to block cortisol release

Question 9

Which one of the following statements concerning erectile dysfunction or ED is correct?

Accepted Answer

A) Smoking, hypertension and diabetes have only negligible effects on ED. 
B) Drugs used to treat ED stimulate muscarinic receptors promoting an erection. 
C) Drugs can cause a runny nose and taste disturbances. 
D) Drugs can cause a dangerous drop in blood pressure when taken with nitrates. 
A) Smoking, hypertension and diabetes have only negligible effects on ED. 
B) Drugs used to treat ED stimulate muscarinic receptors promoting an erection. 
C) Drugs can cause a runny nose and taste disturbances. 
D) Drugs can cause a dangerous drop in blood pressure when taken with nitrates.

Question 10

Levothyroxine ________________.

Accepted Answer

A) is converted to T4 as the active form 
B) has a wide margin of safety 
C) therapy can lead to osteoporosis and fractures 
D) All of the above 
A) is converted to T4 as the active form 
B) has a wide margin of safety 
C) therapy can lead to osteoporosis and fractures 
D) All of the above

Question 11

Which one of the following is contraindicated for the treatment of a 52-year-old woman who suffers from vasomotor instability related to menopause and who also has high risk factors for cardiac disease?

Accepted Answer

A) Hormone replacement therapy (estrogen and medroxyprogesterone) 
B) SSRIs 
C) Antiepilepsy drugs 
D) Phytoestrogens such as soy 
A) Hormone replacement therapy (estrogen and medroxyprogesterone) 
B) SSRIs 
C) Antiepilepsy drugs 
D) Phytoestrogens such as soy

Question 12

Which of the following is a side effect of oral contraceptive agents?

Accepted Answer

A) Ovulation 
B) Gynecomastia 
C) DVT 
D) Improved fertility 
A) Ovulation 
B) Gynecomastia 
C) DVT 
D) Improved fertility

Question 13

Exogenous estrogens ________________.

Accepted Answer

A) increase the risk of manic episodes 
B) increase the risk of endometrial cancer 
C) decrease bone density 
D) cause muscle weakness 
A) increase the risk of manic episodes 
B) increase the risk of endometrial cancer 
C) decrease bone density 
D) cause muscle weakness

Question 14

Hormonal estrogen replacement after menopause ________________.

Accepted Answer

A) reduces significantly hot flashes, atrophic vaginitis, osteoporosis and mood swings 
B) reduces risk of cardiovascular diseases 
C) does not increase the risk of breast cancer since cancer would have appeared before replacement therapy 
D) is now prohibited 
A) reduces significantly hot flashes, atrophic vaginitis, osteoporosis and mood swings 
B) reduces risk of cardiovascular diseases 
C) does not increase the risk of breast cancer since cancer would have appeared before replacement therapy 
D) is now prohibited

Question 15

Which of the following activities is contraindicated for a woman on fertility drugs (menotropins)?

Accepted Answer

A) Whirlpool of the foot 
B) Exercises for the knee on the Cybex 
C) PNF exercises for the upper extremity 
D) Measuring aerobic capacity on a treadmill 
A) Whirlpool of the foot 
B) Exercises for the knee on the Cybex 
C) PNF exercises for the upper extremity 
D) Measuring aerobic capacity on a treadmill

Question 16

Oral contraceptives (estrogen,progestin drugs)________________.

Accepted Answer

A) cause a sperm hostile environment through estrogen's action 
B) inhibit the secretion of FSH and LH and prevent follicular development 
C) contain mostly ethylestrenol 
D) contain mostly stanozolol 
A) cause a sperm hostile environment through estrogen's action 
B) inhibit the secretion of FSH and LH and prevent follicular development 
C) contain mostly ethylestrenol 
D) contain mostly stanozolol

Question 17

The post-coital drug mifepristone ________________.

Accepted Answer

A) antagonizes the effects of androgens causing uterine contractions 
B) is effective only for 14 days after unprotected intercourse 
C) causes the release of estrogens which prevents egg implantation 
D) acts like misoprostol 
A) antagonizes the effects of androgens causing uterine contractions 
B) is effective only for 14 days after unprotected intercourse 
C) causes the release of estrogens which prevents egg implantation 
D) acts like misoprostol

Question 18

Plan B drug ________________.

Accepted Answer

A) uses levonorgestrel which expels the implanted egg 
B) is now available on the pharmacy shelf without a prescription 
C) must be taken within 72 hours 
D) can terminate an existing pregnancy 
A) uses levonorgestrel which expels the implanted egg 
B) is now available on the pharmacy shelf without a prescription 
C) must be taken within 72 hours 
D) can terminate an existing pregnancy

Question 19

HRT with estrogen and medroxyprogesterone is not recommended for which of the following patients?

Accepted Answer

A) 52-year-old women with recurrent colon polyps 
B) 60-year-old women with histories of steroid use and hip fractures 
C) Postmenopausal women with strong family histories of breast cancer 
D) Women undergoing menopause who are experiencing severe vasomotor instability 
A) 52-year-old women with recurrent colon polyps 
B) 60-year-old women with histories of steroid use and hip fractures 
C) Postmenopausal women with strong family histories of breast cancer 
D) Women undergoing menopause who are experiencing severe vasomotor instability

Question 20

Testosterone is indicated in the treatment of anemia for which of the following reasons?

Accepted Answer

A) It facilitates the effect of growth hormone. 
B) It stimulates erythropoietin release. 
C) It interacts with estrogen receptors. 
D) It stimulates the synthesis of protein. 
A) It facilitates the effect of growth hormone. 
B) It stimulates erythropoietin release. 
C) It interacts with estrogen receptors. 
D) It stimulates the synthesis of protein.

Exam 13: Selective Topics in Endocrine Pharmacology

Which one of the following is associated with the exogenous intake of a steroid?

Which one of the following statements is false?

The most commonly used drugs in the treatment of acromegaly simulate which of the following hormones?

Which of the following drugs would not be used to treat a thyroid storm?

You are seeing a patient in therapy who is on replacement therapy for hypothyroidism.Which one of the following responses or observations indicates that this patient's level of thyroid hormone may be too elevated?

Which of the following statements is correct?

Major side effects of oral contraceptives are ________________.

Excessive glucocorticoid secretion ________________.

Which one of the following statements concerning erectile dysfunction or ED is correct?

Levothyroxine ________________.

Which one of the following is contraindicated for the treatment of a 52-year-old woman who suffers from vasomotor instability related to menopause and who also has high risk factors for cardiac disease?

Which of the following is a side effect of oral contraceptive agents?

Exogenous estrogens ________________.

Hormonal estrogen replacement after menopause ________________.

Which of the following activities is contraindicated for a woman on fertility drugs (menotropins)?

Oral contraceptives (estrogen,progestin drugs)________________.

The post-coital drug mifepristone ________________.

Plan B drug ________________.

HRT with estrogen and medroxyprogesterone is not recommended for which of the following patients?

Testosterone is indicated in the treatment of anemia for which of the following reasons?

Introduction

Pharmacodynamics: Mechanism of Action

Pharmacokinetics and Drug Dosing

Adverse Drug Reactions

Drugs Acting on the Autonomic Nervous System

Antihypertensive

Drug Therapy of Coronary Atherosclerosis and Its Repercussions

Drug Therapy for Congestive Heart Failure and Cardiac Arrhythmias

Drug Therapy for Pulmonary Disorders

Anesthetic Agents

Drugs for the Treatment of Pain and Inflammation

Drug Treatment for Arthritis-Related Conditions

Drug Treatment for Osteoporosis and Diabetes

Drugs for Epilepsy and Attention Deficit/Hyperactivity Disorder

Antispasticity Medications and Skeletal Muscle Relaxants

Pharmacologic Management of Degenerative Neurologic Disorders

Drug Treatment for Depression and Anxiety

Drug Treatment for Schizophrenia and Bipolar Illness

Antimicrobial Agents

Antiviral Agents and Selected Drugs for Fungal Infections

Cytotoxic Agents and Immune Modulation

Drugs for Gastrointestinal Disorders

Vitamins and Minerals

Topical Drugs and Treatments Used in Wound Management

Complementary and Alternative Medicine in Pharmacology

Drugs of Abuse: Anabolic Steroids and Other Doping Agents

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