Question 1

All of the following are typical side effects of benzodiazepine except _______________.

Accepted Answer

A) unsteadiness 
B) sleepiness 
C) agitation 
D) memory lapses 
A) unsteadiness 
B) sleepiness 
C) agitation 
D) memory lapses C

Question 2

GABA _______________.

Accepted Answer

A) opens Na⁺ channels causing depolarization 
B) opens Cl⁻ channels causing hyperpolarization 
C) closes Ca⁺⁺ channels causing depolarization 
D) closes Mg⁺⁺ channels causing hyperpolarization 
A) opens Na⁺ channels causing depolarization 
B) opens Cl⁻ channels causing hyperpolarization 
C) closes Ca⁺⁺ channels causing depolarization 
D) closes Mg⁺⁺ channels causing hyperpolarization B

Question 3

Which of the following is a clinical concern when treating a patient on a long-acting benzodiazepine?

Accepted Answer

A) Reduction of REM sleep 
B) Ataxia leading to falls 
C) Polydipsia 
D) Polyphagia 
A) Reduction of REM sleep 
B) Ataxia leading to falls 
C) Polydipsia 
D) Polyphagia B

Question 4

Adverse effects of benzodiazepines include which of the following?

Accepted Answer

A) Drowsiness 
B) Dizziness 
C) Reduced psychomotor performance 
D) All of the above 
A) Drowsiness 
B) Dizziness 
C) Reduced psychomotor performance 
D) All of the above

Question 5

The neurotransmitter system which seems to play no or only a minor role in the pathogenesis of depression is _______________.

Accepted Answer

A) a deficiency of the serotonin system 
B) a deficiency of the norepinephrine system 
C) excess of corticotrophin-releasing hormone 
D) excessive acetylcholine 
A) a deficiency of the serotonin system 
B) a deficiency of the norepinephrine system 
C) excess of corticotrophin-releasing hormone 
D) excessive acetylcholine

Question 6

SSRIs have _______________.

Accepted Answer

A) anticholinergic effects 
B) antihistaminic effects 
C) antiadrenergic effects 
D) None of the above 
A) anticholinergic effects 
B) antihistaminic effects 
C) antiadrenergic effects 
D) None of the above

Question 7

Which of the following statements is correct?

Accepted Answer

A) Barbiturates but not benzodiazepines can cause physical dependence. 
B) Barbiturates and benzodiazepines have the same mode of action. 
C) Barbiturates and benzodiazepines can cause tolerance. 
D) Benzodiazepines are more efficacious in inducing p450 enzymes. 
A) Barbiturates but not benzodiazepines can cause physical dependence. 
B) Barbiturates and benzodiazepines have the same mode of action. 
C) Barbiturates and benzodiazepines can cause tolerance. 
D) Benzodiazepines are more efficacious in inducing p450 enzymes.

Question 8

Which of the following is true regarding MAO-A inhibitors?

Accepted Answer

A) They decrease the release of norepinephrine. 
B) They produce a hypertensive reaction when given with fermented foods. 
C) They produce CNS sedation. 
D) They are more effective than the SSRIs. 
A) They decrease the release of norepinephrine. 
B) They produce a hypertensive reaction when given with fermented foods. 
C) They produce CNS sedation. 
D) They are more effective than the SSRIs.

Question 9

A drug with a short half-life as compared to a drug with a long half-life will cause _______________.

Accepted Answer

A) a more rapid onset of withdrawal syndrome 
B) a milder withdrawal syndrome 
C) a longer withdrawal syndrome 
D) the same withdrawal syndrome with both drugs 
A) a more rapid onset of withdrawal syndrome 
B) a milder withdrawal syndrome 
C) a longer withdrawal syndrome 
D) the same withdrawal syndrome with both drugs

Question 10

All of the following can be ADRs of tricyclic treatment except _______________.

Accepted Answer

A) anticholinergic reactions 
B) antihistaminic reactions 
C) antiadrenergic reactions 
D) antidopaminergic reactions 
A) anticholinergic reactions 
B) antihistaminic reactions 
C) antiadrenergic reactions 
D) antidopaminergic reactions

Question 11

It is thought that most antidepressants _______________.

Accepted Answer

A) increase the synthesis of norepinephrine and/or serotonin 
B) decrease the synthesis of acetylcholine and/or corticotropin-releasing hormone 
C) decrease the re-uptake of norepinephrine and/or serotonin 
D) increase the destruction of corticotrophin-releasing hormone and/or acetylcholine 
A) increase the synthesis of norepinephrine and/or serotonin 
B) decrease the synthesis of acetylcholine and/or corticotropin-releasing hormone 
C) decrease the re-uptake of norepinephrine and/or serotonin 
D) increase the destruction of corticotrophin-releasing hormone and/or acetylcholine

Question 12

Antidepressants usually _______________.

Accepted Answer

A) have a quick onset of therapeutic action 
B) have a delayed onset of therapeutic action 
C) have a delayed onset of adverse reactions 
D) reduce early on the risk of suicide 
A) have a quick onset of therapeutic action 
B) have a delayed onset of therapeutic action 
C) have a delayed onset of adverse reactions 
D) reduce early on the risk of suicide

Question 13

The two neurotransmitters most commonly implicated in the etiology of all anxiety disorders are ___________.

Accepted Answer

A) GABA and epinephrine 
B) Gycine and GABA 
C) Norepinephrine and epinephrine 
D) GABA and serotonin 
A) GABA and epinephrine 
B) Gycine and GABA 
C) Norepinephrine and epinephrine 
D) GABA and serotonin

Question 14

Which of the following is not associated with a benzodiazepine drug?

Accepted Answer

A) Sedation 
B) Impaired hearing 
C) Dizziness 
D) Ataxia 
A) Sedation 
B) Impaired hearing 
C) Dizziness 
D) Ataxia

Question 15

A patient treated with SSRIs might experience _______________.

Accepted Answer

A) sedation 
B) orthostatic hypotension 
C) arrhythmias 
D) akathisia 
A) sedation 
B) orthostatic hypotension 
C) arrhythmias 
D) akathisia

Question 16

SSRIs are preferred over TCAs for which of the following reasons?

Accepted Answer

A) They are more effective at reducing symptoms of depression. 
B) They lack cardiac effects. 
C) They have some α-adrenergic-blocking responses. 
D) They are not addictive. 
A) They are more effective at reducing symptoms of depression. 
B) They lack cardiac effects. 
C) They have some α-adrenergic-blocking responses. 
D) They are not addictive.

Question 17

Which of the drug class-drug combinations is a mismatch?

Accepted Answer

A) Tricyclics - amitriptyline 
B) SSRIs - fluoxetine 
C) MAO inhibitors - moclobenide 
D) anti-pychotic - paroxetine 
A) Tricyclics - amitriptyline 
B) SSRIs - fluoxetine 
C) MAO inhibitors - moclobenide 
D) anti-pychotic - paroxetine

Question 18

Buspirone _______________.

Accepted Answer

A) acts mostly on norepinephrine receptors 
B) has a delayed (about 3 weeks) onset of action 
C) is more effective than the benzodiazepines but also more toxic 
D) All of the above 
A) acts mostly on norepinephrine receptors 
B) has a delayed (about 3 weeks) onset of action 
C) is more effective than the benzodiazepines but also more toxic 
D) All of the above

Exam 18: Drug Treatment for Depression and Anxiety

All of the following are typical side effects of benzodiazepine except _______________.

GABA _______________.

Which of the following is a clinical concern when treating a patient on a long-acting benzodiazepine?

Adverse effects of benzodiazepines include which of the following?

The neurotransmitter system which seems to play no or only a minor role in the pathogenesis of depression is _______________.

SSRIs have _______________.

Which of the following statements is correct?

Which of the following is true regarding MAO-A inhibitors?

A drug with a short half-life as compared to a drug with a long half-life will cause _______________.

All of the following can be ADRs of tricyclic treatment except _______________.

It is thought that most antidepressants _______________.

Antidepressants usually _______________.

The two neurotransmitters most commonly implicated in the etiology of all anxiety disorders are ___________.

Which of the following is not associated with a benzodiazepine drug?

A patient treated with SSRIs might experience _______________.

SSRIs are preferred over TCAs for which of the following reasons?

Which of the drug class-drug combinations is a mismatch?

Buspirone _______________.

Introduction

Pharmacodynamics: Mechanism of Action

Pharmacokinetics and Drug Dosing

Adverse Drug Reactions

Drugs Acting on the Autonomic Nervous System

Antihypertensive

Drug Therapy of Coronary Atherosclerosis and Its Repercussions

Drug Therapy for Congestive Heart Failure and Cardiac Arrhythmias

Drug Therapy for Pulmonary Disorders

Anesthetic Agents

Drugs for the Treatment of Pain and Inflammation

Drug Treatment for Arthritis-Related Conditions

Selective Topics in Endocrine Pharmacology

Drug Treatment for Osteoporosis and Diabetes

Drugs for Epilepsy and Attention Deficit/Hyperactivity Disorder

Antispasticity Medications and Skeletal Muscle Relaxants

Pharmacologic Management of Degenerative Neurologic Disorders

Drug Treatment for Schizophrenia and Bipolar Illness

Antimicrobial Agents

Antiviral Agents and Selected Drugs for Fungal Infections

Cytotoxic Agents and Immune Modulation

Drugs for Gastrointestinal Disorders

Vitamins and Minerals

Topical Drugs and Treatments Used in Wound Management

Complementary and Alternative Medicine in Pharmacology

Drugs of Abuse: Anabolic Steroids and Other Doping Agents

Filters