Question 1

Which of the following statements is false?

Accepted Answer

A) Thromboxane A2 causes platelet aggregation. 
B) Leukotrienes cause vasoconstriction. 
C) Leukotrienes and thromboxane are formed by cyclooxygenase. 
D) Thrombin converts fibrinogen to fibrin. 
A) Thromboxane A2 causes platelet aggregation. 
B) Leukotrienes cause vasoconstriction. 
C) Leukotrienes and thromboxane are formed by cyclooxygenase. 
D) Thrombin converts fibrinogen to fibrin. C

Question 2

A patient who is taking sublingual nitrates reports dizziness after dosing.What should your response to the patient be?

Accepted Answer

A) Sit or lie down to prevent dizziness. 
B) Drink water to wash any remaining nitrates out of the mouth. 
C) Perform isometric fisting exercises. 
D) Take a second nitrate. 
A) Sit or lie down to prevent dizziness. 
B) Drink water to wash any remaining nitrates out of the mouth. 
C) Perform isometric fisting exercises. 
D) Take a second nitrate. A

Question 3

Thrombolytic agents _________.

Accepted Answer

A) facilitate the action of warfarin 
B) must be given within 12 hrs of an MI 
C) are given by infusion 
D) can save all or some of the myocardium from the damaging effects of ischemia 
A) facilitate the action of warfarin 
B) must be given within 12 hrs of an MI 
C) are given by infusion 
D) can save all or some of the myocardium from the damaging effects of ischemia B

Question 4

Which of the following statements about statin drugs is false?

Accepted Answer

A) They inhibit endogenous formation of cholesterol. 
B) They vary greatly in efficacy. 
C) They carry the risk of liver and muscle damage. 
D) Cost can be a factor in choosing the right drug. 
A) They inhibit endogenous formation of cholesterol. 
B) They vary greatly in efficacy. 
C) They carry the risk of liver and muscle damage. 
D) Cost can be a factor in choosing the right drug.

Question 5

Which one of the following statements concerning heparin is false?

Accepted Answer

A) It can be administered at different molecular weights. 
B) It prevents the conversion of prothrombin to thrombin. 
C) It is used to treat deep vein thrombosis, pulmonary embolism, and selected cases of MIs. 
D) It can cause excessive bleeding, which cannot be easily stopped. 
A) It can be administered at different molecular weights. 
B) It prevents the conversion of prothrombin to thrombin. 
C) It is used to treat deep vein thrombosis, pulmonary embolism, and selected cases of MIs. 
D) It can cause excessive bleeding, which cannot be easily stopped.

Question 6

Patients using aspirin _________.

Accepted Answer

A) should be watched for bruising and joint swelling 
B) and NSAIDs simultaneously experience reduced aspirin effects 
C) can expect adverse GI-effects 
D) and experiencing the first signs of a MI or stroke should take one 325 mg aspirin 
A) should be watched for bruising and joint swelling 
B) and NSAIDs simultaneously experience reduced aspirin effects 
C) can expect adverse GI-effects 
D) and experiencing the first signs of a MI or stroke should take one 325 mg aspirin

Question 7

You are treating a patient who is wearing a nitroglycerin transdermal patch.Which of the following interventions would be most contraindicated?

Accepted Answer

A) Dexterity training 
B) Hand exercises with the aid of a biofeedback device 
C) Ultrasound to the knee 
D) Hot pack application to the left shoulder 
A) Dexterity training 
B) Hand exercises with the aid of a biofeedback device 
C) Ultrasound to the knee 
D) Hot pack application to the left shoulder

Question 8

The role of nitrates in the treatment of angina is to do which of the following?

Accepted Answer

A) Reduce cardiac contractility 
B) Enhance sodium excretion 
C) Reduce preload and afterload 
D) Increase the heart rate 
A) Reduce cardiac contractility 
B) Enhance sodium excretion 
C) Reduce preload and afterload 
D) Increase the heart rate

Question 9

Aspirin _________.

Accepted Answer

A) inhibits platelet aggregation 
B) inhibits the enzyme cyclooxygenase reversibly 
C) is given as 80 mg per day for its anti-platelet effect 
D) allows normal platelet function about 32 hours after cessation of therapy 
A) inhibits platelet aggregation 
B) inhibits the enzyme cyclooxygenase reversibly 
C) is given as 80 mg per day for its anti-platelet effect 
D) allows normal platelet function about 32 hours after cessation of therapy

Question 10

Which of the following represents a therapeutic dose of warfarin (oral anticoagulant)? An INR = _____________.

Accepted Answer

A) 1 to 2 
B) 1.5 to 2.0 
C) 2.0 to 3.0 
D) 3.0 to 4.0 
A) 1 to 2 
B) 1.5 to 2.0 
C) 2.0 to 3.0 
D) 3.0 to 4.0

Question 11

Which of the following statements concerning clopidogrel and ticlopidine is false?

Accepted Answer

A) They block prostaglandin induced platelet aggregation. 
B) It takes about a week for normal platelet functions to recover after therapy has stopped. 
C) They can cause increased bleeding episodes. 
D) They can increase the risk of hemorrhagic strokes. 
A) They block prostaglandin induced platelet aggregation. 
B) It takes about a week for normal platelet functions to recover after therapy has stopped. 
C) They can cause increased bleeding episodes. 
D) They can increase the risk of hemorrhagic strokes.

Question 12

Which one of the following adverse effects is associated with nitroglycerin?

Accepted Answer

A) Hypertension 
B) Throbbing headache 
C) Bradycardia 
D) Abdominal bloating 
A) Hypertension 
B) Throbbing headache 
C) Bradycardia 
D) Abdominal bloating

Question 13

When working with patients on statins,you should ask the patient to report which of the following side effects?

Accepted Answer

A) Muscle pain 
B) Headache 
C) Fatigue 
D) Bruising 
A) Muscle pain 
B) Headache 
C) Fatigue 
D) Bruising

Question 14

Which one of the following statements is false?

Accepted Answer

A) Bile acid binding drugs will remain in the intestines but can interfere with the action of other drugs. 
B) Fibrates act to decrease lipoprotein lipase and increase the risk of kidney stones. 
C) Niacin reduces free fatty acid mobilization and causes flushing and GI-upset. 
D) A dark urine can be indicative of drug-induced muscle damage. 
A) Bile acid binding drugs will remain in the intestines but can interfere with the action of other drugs. 
B) Fibrates act to decrease lipoprotein lipase and increase the risk of kidney stones. 
C) Niacin reduces free fatty acid mobilization and causes flushing and GI-upset. 
D) A dark urine can be indicative of drug-induced muscle damage.

Question 15

Which one of the following combinations is false?

Accepted Answer

A) Nitrates can cause a throbbing headache. 
B) Beta-blockers can cause dyspnea during exercise. 
C) Calcium channel blockers can cause a severe cough. 
D) All of the above 
A) Nitrates can cause a throbbing headache. 
B) Beta-blockers can cause dyspnea during exercise. 
C) Calcium channel blockers can cause a severe cough. 
D) All of the above

Question 16

A patient in ambulation training is on warfarin after a stroke.He is developing some tendonitis and is asking your opinion on which aspirin-type drug is better for pain,Aleve or Motrin.Your best response should be which of the following?

Accepted Answer

A) Inform the patient of the potential drug interactions with anticoagulants. 
B) Inform the patient to administer a 650-mg dose of aspirin. 
C) Explain that tendonitis is an expected outcome of therapy and it will improve shortly with more therapy. 
D) Suggest that the patient take ibuprofen instead. 
A) Inform the patient of the potential drug interactions with anticoagulants. 
B) Inform the patient to administer a 650-mg dose of aspirin. 
C) Explain that tendonitis is an expected outcome of therapy and it will improve shortly with more therapy. 
D) Suggest that the patient take ibuprofen instead.

Question 17

Nitrates _________.

Accepted Answer

A) should be used 24 hrs for at least 2 weeks at the beginning of therapy 
B) may have their anti-anginal effect hastened by the patient if he/she leans back and takes short breaths 
C) might be used 4-6 times before an attack is terminated 
D) taken sublingually should produce a tingling or burning sensation 
A) should be used 24 hrs for at least 2 weeks at the beginning of therapy 
B) may have their anti-anginal effect hastened by the patient if he/she leans back and takes short breaths 
C) might be used 4-6 times before an attack is terminated 
D) taken sublingually should produce a tingling or burning sensation

Question 18

Transdermal nitroglycerin patches are indicated for which of the following conditions?

Accepted Answer

A) To end angina 
B) For use with ventricular fibrillation 
C) To prevent angina 
D) For use with type II heart block 
A) To end angina 
B) For use with ventricular fibrillation 
C) To prevent angina 
D) For use with type II heart block

Question 19

Beta-blockers _________.

Accepted Answer

A) act by reducing heart rate and contractility 
B) are beneficial in all types of angina 
C) should not reduce heart rate below 80 beats/min 
D) All of the above 
A) act by reducing heart rate and contractility 
B) are beneficial in all types of angina 
C) should not reduce heart rate below 80 beats/min 
D) All of the above

Question 20

Thrombolytic agents are useful after a myocardial infarction to ______________.

Accepted Answer

A) act as an anticoagulant 
B) lyse the blood clot 
C) dilate the coronary arteries 
D) constrict the coronary arteries 
A) act as an anticoagulant 
B) lyse the blood clot 
C) dilate the coronary arteries 
D) constrict the coronary arteries

Exam 7: Drug Therapy of Coronary Atherosclerosis and Its Repercussions

Which of the following statements is false?

A patient who is taking sublingual nitrates reports dizziness after dosing.What should your response to the patient be?

Thrombolytic agents _________.

Which of the following statements about statin drugs is false?

Which one of the following statements concerning heparin is false?

Patients using aspirin _________.

You are treating a patient who is wearing a nitroglycerin transdermal patch.Which of the following interventions would be most contraindicated?

The role of nitrates in the treatment of angina is to do which of the following?

Aspirin _________.

Which of the following represents a therapeutic dose of warfarin (oral anticoagulant)? An INR = _____________.

Which of the following statements concerning clopidogrel and ticlopidine is false?

Which one of the following adverse effects is associated with nitroglycerin?

When working with patients on statins,you should ask the patient to report which of the following side effects?

Which one of the following statements is false?

Which one of the following combinations is false?

A patient in ambulation training is on warfarin after a stroke.He is developing some tendonitis and is asking your opinion on which aspirin-type drug is better for pain,Aleve or Motrin.Your best response should be which of the following?

Nitrates _________.

Transdermal nitroglycerin patches are indicated for which of the following conditions?

Beta-blockers _________.

Thrombolytic agents are useful after a myocardial infarction to ______________.

Introduction

Pharmacodynamics: Mechanism of Action

Pharmacokinetics and Drug Dosing

Adverse Drug Reactions

Drugs Acting on the Autonomic Nervous System

Antihypertensive

Drug Therapy for Congestive Heart Failure and Cardiac Arrhythmias

Drug Therapy for Pulmonary Disorders

Anesthetic Agents

Drugs for the Treatment of Pain and Inflammation

Drug Treatment for Arthritis-Related Conditions

Selective Topics in Endocrine Pharmacology

Drug Treatment for Osteoporosis and Diabetes

Drugs for Epilepsy and Attention Deficit/Hyperactivity Disorder

Antispasticity Medications and Skeletal Muscle Relaxants

Pharmacologic Management of Degenerative Neurologic Disorders

Drug Treatment for Depression and Anxiety

Drug Treatment for Schizophrenia and Bipolar Illness

Antimicrobial Agents

Antiviral Agents and Selected Drugs for Fungal Infections

Cytotoxic Agents and Immune Modulation

Drugs for Gastrointestinal Disorders

Vitamins and Minerals

Topical Drugs and Treatments Used in Wound Management

Complementary and Alternative Medicine in Pharmacology

Drugs of Abuse: Anabolic Steroids and Other Doping Agents

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