Question 1

The drug with the longest duration of action is _____________.

Accepted Answer

A) botulinus toxin 
B) diazepam 
C) cyclobenzaprine 
D) baclofen 
A) botulinus toxin 
B) diazepam 
C) cyclobenzaprine 
D) baclofen A

Question 2

Which of the following drugs is used for muscle spasms?

Accepted Answer

A) Tizanidine 
B) Cyclobenzaprine 
C) Botulinus toxin 
D) Dantrolene 
A) Tizanidine 
B) Cyclobenzaprine 
C) Botulinus toxin 
D) Dantrolene B

Question 3

Advantages of neurolytic agents include _____________.

Accepted Answer

A) rapid onset of action 
B) low cost 
C) action on both sensory and motor nerves 
D) All of the above 
A) rapid onset of action 
B) low cost 
C) action on both sensory and motor nerves 
D) All of the above D

Question 4

Dantrolene _____________.

Accepted Answer

A) reduces Ca⁺⁺ fluxes at the sarcoplasmic reticulum 
B) is ineffective for upper motoneuron disease or injury 
C) can cause malignant hyperthermia 
D) acts only peripherally without causing CNS effects 
A) reduces Ca⁺⁺ fluxes at the sarcoplasmic reticulum 
B) is ineffective for upper motoneuron disease or injury 
C) can cause malignant hyperthermia 
D) acts only peripherally without causing CNS effects

Question 5

Lack of functional gain when baclofen or another antispasticity agent is administered may be caused by which of the following?

Accepted Answer

A) Muscle weakness 
B) Seizures 
C) Rebound spasticity 
D) Enhanced muscle spindle sensitivity 
A) Muscle weakness 
B) Seizures 
C) Rebound spasticity 
D) Enhanced muscle spindle sensitivity

Question 6

Fluori-Methane _____________.

Accepted Answer

A) should be sprayed from muscle insertion to origin of muscle 
B) spray should be applied to an untouched muscle 
C) should be sprayed until the muscle is super-cooled 
D) can be reapplied after the muscle has warmed 
A) should be sprayed from muscle insertion to origin of muscle 
B) spray should be applied to an untouched muscle 
C) should be sprayed until the muscle is super-cooled 
D) can be reapplied after the muscle has warmed

Question 7

Disadvantages of neurolytic agents include _____________.

Accepted Answer

A) risk of dysesthesias 
B) involuntary muscle contractions 
C) hypertrophy of skeletal muscles 
D) All of the above 
A) risk of dysesthesias 
B) involuntary muscle contractions 
C) hypertrophy of skeletal muscles 
D) All of the above

Question 8

A patient treated with antispastic medications would not be expected to experience _____________.

Accepted Answer

A) muscle weakness 
B) decreased walking speed 
C) renal problems 
D) sedation 
A) muscle weakness 
B) decreased walking speed 
C) renal problems 
D) sedation

Question 9

The antispastic action of diazepam _____________.

Accepted Answer

A) is due to its binding to the GABAA gated Cl⁻ channel 
B) occurs within the motor cortex and basal ganglia 
C) occurs also by an additional direct effect on skeletal muscles 
D) All of the above 
A) is due to its binding to the GABAA gated Cl⁻ channel 
B) occurs within the motor cortex and basal ganglia 
C) occurs also by an additional direct effect on skeletal muscles 
D) All of the above

Question 10

Which of the following statements is correct?

Accepted Answer

A) Botulinus toxin selectively destroys skeletal muscle cholinergic receptors. 
B) A nerve block is caused by an injected chemical which impairs nerve function. 
C) Ethanol causes a nerve block lasting up to 6 months. 
D) Ethanol selectively destroys the spinal nerve terminals. 
A) Botulinus toxin selectively destroys skeletal muscle cholinergic receptors. 
B) A nerve block is caused by an injected chemical which impairs nerve function. 
C) Ethanol causes a nerve block lasting up to 6 months. 
D) Ethanol selectively destroys the spinal nerve terminals.

Question 11

Botulinus toxins _____________.

Accepted Answer

A) consist of two distinct species 
B) begin working within 2 hours 
C) have been associated with some muscle necrosis 
D) might cause some transient muscle weakness 
A) consist of two distinct species 
B) begin working within 2 hours 
C) have been associated with some muscle necrosis 
D) might cause some transient muscle weakness

Question 12

Baclofen _____________.

Accepted Answer

A) is an analog of the neurotransmitter glutamic acid 
B) may improve memory and attention 
C) in overdose causes extreme agitation and seizures 
D) can reduce spasticity and improve gait and ADLs 
A) is an analog of the neurotransmitter glutamic acid 
B) may improve memory and attention 
C) in overdose causes extreme agitation and seizures 
D) can reduce spasticity and improve gait and ADLs

Question 13

Cyclobenzaprine _____________.

Accepted Answer

A) acts in the spinal cord 
B) can be used for months 
C) can cause an uncomfortable dry mouth 
D) relaxes muscles but has no effect on pain 
A) acts in the spinal cord 
B) can be used for months 
C) can cause an uncomfortable dry mouth 
D) relaxes muscles but has no effect on pain

Question 14

Tizanidine _____________.

Accepted Answer

A) interacts with beta 1 receptors in the CNS 
B) affects mostly monosynaptic pathways 
C) treated patients must be watched for signs of tachycardia and hypertension 
D) shows the least muscle weakness among antispastic medications 
A) interacts with beta 1 receptors in the CNS 
B) affects mostly monosynaptic pathways 
C) treated patients must be watched for signs of tachycardia and hypertension 
D) shows the least muscle weakness among antispastic medications

Exam 16: Antispasticity Medications and Skeletal Muscle Relaxants

The drug with the longest duration of action is _____________.

Which of the following drugs is used for muscle spasms?

Advantages of neurolytic agents include _____________.

Dantrolene _____________.

Lack of functional gain when baclofen or another antispasticity agent is administered may be caused by which of the following?

Fluori-Methane _____________.

Disadvantages of neurolytic agents include _____________.

A patient treated with antispastic medications would not be expected to experience _____________.

The antispastic action of diazepam _____________.

Which of the following statements is correct?

Botulinus toxins _____________.

Baclofen _____________.

Cyclobenzaprine _____________.

Tizanidine _____________.

Introduction

Pharmacodynamics: Mechanism of Action

Pharmacokinetics and Drug Dosing

Adverse Drug Reactions

Drugs Acting on the Autonomic Nervous System

Antihypertensive

Drug Therapy of Coronary Atherosclerosis and Its Repercussions

Drug Therapy for Congestive Heart Failure and Cardiac Arrhythmias

Drug Therapy for Pulmonary Disorders

Anesthetic Agents

Drugs for the Treatment of Pain and Inflammation

Drug Treatment for Arthritis-Related Conditions

Selective Topics in Endocrine Pharmacology

Drug Treatment for Osteoporosis and Diabetes

Drugs for Epilepsy and Attention Deficit/Hyperactivity Disorder

Pharmacologic Management of Degenerative Neurologic Disorders

Drug Treatment for Depression and Anxiety

Drug Treatment for Schizophrenia and Bipolar Illness

Antimicrobial Agents

Antiviral Agents and Selected Drugs for Fungal Infections

Cytotoxic Agents and Immune Modulation

Drugs for Gastrointestinal Disorders

Vitamins and Minerals

Topical Drugs and Treatments Used in Wound Management

Complementary and Alternative Medicine in Pharmacology

Drugs of Abuse: Anabolic Steroids and Other Doping Agents

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