Question 1

What is the mechanism for the platelet dysfunction in multiple myeloma and Waldenström macroglobulinemia?

Accepted Answer

A) Granules become deficient. 
B) Platelets are coated with paraprotein. 
C) Nitric oxide is not produced. 
D) Cyclooxygenase is acetylated. 
A) Granules become deficient. 
B) Platelets are coated with paraprotein. 
C) Nitric oxide is not produced. 
D) Cyclooxygenase is acetylated. B

Question 2

Which of the following is true regarding testing for the diagnosis of vascular disorders?

Accepted Answer

A) Most do not have abnormal clinical laboratory tests. 
B) The platelet count and aggregometry are useful. 
C) The prothrombin time (PT) and partial thromboplastin time (PTT) are most useful. 
D) Evaluation of von Willebrand factor (VWF) is useful. 
A) Most do not have abnormal clinical laboratory tests. 
B) The platelet count and aggregometry are useful. 
C) The prothrombin time (PT) and partial thromboplastin time (PTT) are most useful. 
D) Evaluation of von Willebrand factor (VWF) is useful. A

Question 3

A 78-year-old patient recently noticed dark blotches on his forearms and on the backs of his hands.He seems to bruise even when a phlebotomy is performed using excellent technique with no problems encountered.No other symptoms exist,and all laboratory tests are normal.Which of the following is the most likely diagnosis?

Accepted Answer

A) hereditary hemorrhagic telangiectasia 
B) Ehlers-Danlos syndrome 
C) paraproteinemia and amyloidosis 
D) senile purpura 
A) hereditary hemorrhagic telangiectasia 
B) Ehlers-Danlos syndrome 
C) paraproteinemia and amyloidosis 
D) senile purpura D

Question 4

Clopidogrel (Plavix)is a drug used therapeutically for patients with a risk of arterial thrombi because it

Accepted Answer

A) inhibits thrombin. 
B) activates the protein C pathway. 
C) inhibits platelet function. 
D) activates plasminogen. 
A) inhibits thrombin. 
B) activates the protein C pathway. 
C) inhibits platelet function. 
D) activates plasminogen.

Question 5

Which of the following is normal in a patient regularly taking aspirin?

Accepted Answer

A) platelet aggregation 
B) platelet cyclooxygenase function 
C) synthesis of thromboxane A2 
D) platelet count 
A) platelet aggregation 
B) platelet cyclooxygenase function 
C) synthesis of thromboxane A2 
D) platelet count

Question 6

Platelet count and function studies are performed on a patient with a history of easy bruising,and the following results are obtained:
$\begin{array}{ll}
\underline { \text { Test  }}&\underline { \text {  Result }}\
\text { Platelet count } & 295 \times 10^{9} / \mathrm{L} \
\text { Platelet function assay } & \text { Prolonged } \
\text { Platelet aggregation with epinephrine } & \text { Primary but no secondary wave } \
\text { Platelet aggregation with low-dose adenosine } & \text { Primary but no secondary wave }\
\text { diphosphate (ADP) }\
\text { Platelet agoregation with ristocetin }& \text { Normal }\
\end{array}$
What is the most likely diagnosis for this patient?

Accepted Answer

A) Bernard-Soulier disease 
B) dense granule deficiency 
C) Glanzmann thrombasthenia 
D) gray platelet syndrome 
A) Bernard-Soulier disease 
B) dense granule deficiency 
C) Glanzmann thrombasthenia 
D) gray platelet syndrome

Question 7

Which of the following is the most likely diagnosis for a patient with a normal platelet count and no aggregation with any agent except ristocetin?

Accepted Answer

A) aspirin ingestion 
B) gray platelet syndrome 
C) vitamin C deficiency 
D) Glanzmann thrombasthenia 
A) aspirin ingestion 
B) gray platelet syndrome 
C) vitamin C deficiency 
D) Glanzmann thrombasthenia

Question 8

All of the following are common conditions or situations that interfere with platelet function except

Accepted Answer

A) liver disease 
B) uremia 
C) allergic purpura 
D) cardiopulmonary bypass surgery 
A) liver disease 
B) uremia 
C) allergic purpura 
D) cardiopulmonary bypass surgery

Question 9

Which of the following is the most common cause of acquired platelet dysfunction?

Accepted Answer

A) myeloproliferative disorders 
B) Wiskott-Aldrich syndrome 
C) drugs, especially aspirin 
D) afibrinogenemia 
A) myeloproliferative disorders 
B) Wiskott-Aldrich syndrome 
C) drugs, especially aspirin 
D) afibrinogenemia

Question 10

What types of hemostatic complications are found in patients with myeloproliferative disorders?

Accepted Answer

A) hemorrhagic 
B) thrombotic 
C) abnormal platelet function 
D) all of the above 
A) hemorrhagic 
B) thrombotic 
C) abnormal platelet function 
D) all of the above

Question 11

Which of the following is a disorder with absent platelet glycoprotein Ib/IX/V and in which the patient has moderate thrombocytopenia,large platelets,and normal aggregometry with all agents except ristocetin?

Accepted Answer

A) von Willebrand disorder (VW
D)  
B) Bernard-Soulier syndrome 
C) Glanzmann thrombasthenia 
D) dense granule deficiency 
A) von Willebrand disorder (VW
D)  
B) Bernard-Soulier syndrome 
C) Glanzmann thrombasthenia 
D) dense granule deficiency

Question 12

The qualitative platelet disorders and vascular disorders typically exhibit what type of symptoms?

Accepted Answer

A) superficial bleeding 
B) deep tissue bleeding 
C) hemarthrosis 
D) thrombosis 
A) superficial bleeding 
B) deep tissue bleeding 
C) hemarthrosis 
D) thrombosis

Exam 41: Qualitative Disorders of Platelets and Vasculature

What is the mechanism for the platelet dysfunction in multiple myeloma and Waldenström macroglobulinemia?

Which of the following is true regarding testing for the diagnosis of vascular disorders?

Clopidogrel (Plavix)is a drug used therapeutically for patients with a risk of arterial thrombi because it

Which of the following is normal in a patient regularly taking aspirin?

Which of the following is the most likely diagnosis for a patient with a normal platelet count and no aggregation with any agent except ristocetin?

All of the following are common conditions or situations that interfere with platelet function except

Which of the following is the most common cause of acquired platelet dysfunction?

What types of hemostatic complications are found in patients with myeloproliferative disorders?

Which of the following is a disorder with absent platelet glycoprotein Ib/IX/V and in which the patient has moderate thrombocytopenia,large platelets,and normal aggregometry with all agents except ristocetin?

The qualitative platelet disorders and vascular disorders typically exhibit what type of symptoms?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

Filters