Exam 33: Myeloproliferative Neoplasms

A patient has a normal white blood count,a moderately high platelet count,and mild anemia.The differential shows immature granulocytes,nucleated red cells,and teardrop-shaped red cells.Which of the following is most likely?

A patient has a platelet count of 1200 × 10⁹/L.Many platelets are giant and have abnormal shapes.A mild anemia is present.The bone marrow has increased megakaryocytes in clusters;iron stores are present.Which of the following is most likely?

Although found in most chronic myeloproliferative disorders,increased fibrosis detected by the silver techniques and trichrome stain is the key feature of

Which of the following would be an unexpected finding in chronic myelogenous leukemia?

The Janus kinase (JAK)mutation is seen in more than 90% of cases of what disease?

A patient has an increased red count,hemoglobin,and hematocrit.Which of the following features points to secondary polycythemia over polycythemia vera?

All of the following are included in the chronic myeloproliferative disorders except

The bone marrow fibrosis observed in primary myelofibrosis is due to

What clinical feature is more often associated with essential thrombocytosis than with the other chronic myeloproliferative disorders?

Chronic myelogenous leukemia often progresses to

Which of the following is the most specific laboratory test to diagnose chronic myelogenous leukemia?

Which of the following would be an unexpected finding in primary myelofibrosis?

Which chronic myeloproliferative disorder is treated with imatinib mesylate (Gleevec),a drug that inhibits tyrosine kinase?

Which of the following is true for chronic myelogenous leukemia?

Which of the following is true for the mutated erythroid progenitors in polycythemia vera?

Bone marrow or stem cell transplantation is the therapy of choice for patients younger than 55 years old with

The Philadelphia chromosome

A high red count,hemoglobin,and hematocrit are found in all of the following except

Which of the following is an expected finding in polycythemia vera?

What do all chronic myeloproliferative disorders share?