Question 1

Which of the following therapies actually lyses the clot rather than prevents future clots?

Accepted Answer

A) aspirin 
B) heparin 
C) TPA 
D) Coumadin 
A) aspirin 
B) heparin 
C) TPA 
D) Coumadin C

Question 2

What protein does heparin work with to inhibit coagulation?

Accepted Answer

A) protein S 
B) antithrombin 
C) vitamin K 
D) factor VII 
A) protein S 
B) antithrombin 
C) vitamin K 
D) factor VII B

Question 3

On what does factor VIII depend for stability?

Accepted Answer

A) VWF 
B) platelets 
C) thrombin 
D) protein S 
A) VWF 
B) platelets 
C) thrombin 
D) protein S A

Question 4

Which of the following is part of primary hemostasis?

Accepted Answer

A) fibrinolysis 
B) blood vessels 
C) intrinsic system 
D) inhibitors 
A) fibrinolysis 
B) blood vessels 
C) intrinsic system 
D) inhibitors

Question 5

What is the role cofactors play in the procoagulant process?

Accepted Answer

A) bind fibrinolytic factors to slow down lysis of the clot 
B) bind Ca2+ to form a bridge with platelet phospholipids 
C) bind to their specific activated serine protease to stabilize the protease and increase its activity 
D) bind to collagen to aid in platelet adhesion 
A) bind fibrinolytic factors to slow down lysis of the clot 
B) bind Ca2+ to form a bridge with platelet phospholipids 
C) bind to their specific activated serine protease to stabilize the protease and increase its activity 
D) bind to collagen to aid in platelet adhesion

Question 6

What substance is known to inactivate cyclooxygenase,causing impairment of platelet function?

Accepted Answer

A) aspirin 
B) calcium 
C) Tylenol 
D) vitamin K 
A) aspirin 
B) calcium 
C) Tylenol 
D) vitamin K

Question 7

Which of the following is necessary for platelet aggregation?

Accepted Answer

A) protein S 
B) kallikrein 
C) vitamin K 
D) fibrinogen 
A) protein S 
B) kallikrein 
C) vitamin K 
D) fibrinogen

Question 8

Oral anticoagulation is based on

Accepted Answer

A) increasing plasminogen. 
B) activating plasmin. 
C) combining with antithrombin. 
D) vitamin K antagonism. 
A) increasing plasminogen. 
B) activating plasmin. 
C) combining with antithrombin. 
D) vitamin K antagonism.

Question 9

What vitamin is essential for normal synthesis of prothrombin group proteins,thus enabling them to bind Ca²⁺?

Accepted Answer

A) vitamin K 
B) vitamin B12 
C) vitamin C 
D) vitamin D 
A) vitamin K 
B) vitamin B12 
C) vitamin C 
D) vitamin D

Question 10

What substance digests the fibrin clot after healing?

Accepted Answer

A) plasmin 
B) activated protein C 
C) TPA 
D) $\alpha$2-Antiplasmin 
A) plasmin 
B) activated protein C 
C) TPA 
D) $\alpha$2-Antiplasmin

Question 11

What happens to the fibrin monomers created when thrombin cleaves fibrinopeptides A and B from fibrinogen?

Accepted Answer

A) immediately inactivated to prevent excess clotting 
B) converted to plasminogen 
C) digested quickly by tissue plasminogen activator (TP
A)  
D) polymerized and are stabilized by factor XIIIa 
A) immediately inactivated to prevent excess clotting 
B) converted to plasminogen 
C) digested quickly by tissue plasminogen activator (TP
A)  
D) polymerized and are stabilized by factor XIIIa

Question 12

Absence of D dimers is useful for ruling out

Accepted Answer

A) deep venous thrombosis (DVT) 
B) von Willebrand disease (vW
D)  
C) protein C deficiency 
D) factor VII deficiency 
A) deep venous thrombosis (DVT) 
B) von Willebrand disease (vW
D)  
C) protein C deficiency 
D) factor VII deficiency

Question 13

Which of the following is true regarding the plasma coagulation zymogens?

Accepted Answer

A) circulate normally in their active form 
B) are serine proteases that form complexes to activate other zymogens to ultimately generate thrombin 
C) activation normally occurs throughout the body when vascular injury occurs 
D) are cofactors that induce peptide bonding to make larger active molecules 
A) circulate normally in their active form 
B) are serine proteases that form complexes to activate other zymogens to ultimately generate thrombin 
C) activation normally occurs throughout the body when vascular injury occurs 
D) are cofactors that induce peptide bonding to make larger active molecules

Question 14

What is the role of the thrombin-thrombomodulin complex?

Accepted Answer

A) initiates vasoconstriction 
B) activates thrombin 
C) inhibits factor Xa 
D) activates protein C 
A) initiates vasoconstriction 
B) activates thrombin 
C) inhibits factor Xa 
D) activates protein C

Question 15

What are the primary procoagulant roles of the blood vessel?

Accepted Answer

A) constrict and provide collagen and other compounds to activate clotting 
B) prevent the blood from escaping and promote fibrinolysis 
C) secrete platelet growth factors and manufacture calcium 
D) constrict and synthesize most plasma coagulation factors 
A) constrict and provide collagen and other compounds to activate clotting 
B) prevent the blood from escaping and promote fibrinolysis 
C) secrete platelet growth factors and manufacture calcium 
D) constrict and synthesize most plasma coagulation factors

Question 16

Which of the following is the most important protease of the coagulation pathway because of its role in so many different catalytic functions?

Accepted Answer

A) thrombin 
B) factor XIa 
C) plasmin 
D) factor VIIa 
A) thrombin 
B) factor XIa 
C) plasmin 
D) factor VIIa

Question 17

Where are most of the plasma procoagulant proteins produced?

Accepted Answer

A) liver 
B) megakaryocytes 
C) endothelial cells 
D) spleen 
A) liver 
B) megakaryocytes 
C) endothelial cells 
D) spleen

Question 18

Which of the following aids in preventing excess clotting?

Accepted Answer

A) thrombin 
B) factor VII 
C) nitric oxide 
D) protein C 
A) thrombin 
B) factor VII 
C) nitric oxide 
D) protein C

Question 19

Patients who have a deficiency of protein C or protein S have which type of disorder?

Accepted Answer

A) bleeding disorder 
B) thrombotic disorder 
C) bruising disorder 
D) hypercalcemia 
A) bleeding disorder 
B) thrombotic disorder 
C) bruising disorder 
D) hypercalcemia

Question 20

What plasma protein is important for normal wound healing and stabilization of the fibrin clot?

Accepted Answer

A) tissue factor 
B) prothrombin 
C) factor Xa 
D) factor XIIIa 
A) tissue factor 
B) prothrombin 
C) factor Xa 
D) factor XIIIa

Exam 37: Normal Hemostasis and Coagulation

Which of the following therapies actually lyses the clot rather than prevents future clots?

What protein does heparin work with to inhibit coagulation?

On what does factor VIII depend for stability?

Which of the following is part of primary hemostasis?

What is the role cofactors play in the procoagulant process?

What substance is known to inactivate cyclooxygenase,causing impairment of platelet function?

Which of the following is necessary for platelet aggregation?

Oral anticoagulation is based on

What vitamin is essential for normal synthesis of prothrombin group proteins,thus enabling them to bind Ca²⁺?

What substance digests the fibrin clot after healing?

What happens to the fibrin monomers created when thrombin cleaves fibrinopeptides A and B from fibrinogen?

Absence of D dimers is useful for ruling out

Which of the following is true regarding the plasma coagulation zymogens?

What is the role of the thrombin-thrombomodulin complex?

What are the primary procoagulant roles of the blood vessel?

Which of the following is the most important protease of the coagulation pathway because of its role in so many different catalytic functions?

Where are most of the plasma procoagulant proteins produced?

Which of the following aids in preventing excess clotting?

Patients who have a deficiency of protein C or protein S have which type of disorder?

What plasma protein is important for normal wound healing and stabilization of the fibrin clot?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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