Question 1

Which of the following disorders would be consistent with the previously mentioned parameters?

Accepted Answer

A) anemia of chronic disease 
B) aplastic anemia 
C) vitamin B12 deficiency 
D) thalassemia 
A) anemia of chronic disease 
B) aplastic anemia 
C) vitamin B12 deficiency 
D) thalassemia C

Question 2

What is the approximate average life span of a normal RBC in circulation?

Accepted Answer

A) 10 Days 
B) 20 Days 
C) 80 Days 
D) 120 Days 
A) 10 Days 
B) 20 Days 
C) 80 Days 
D) 120 Days D

Question 3

Which of the following is true of ineffective erythropoiesis?

Accepted Answer

A) Lymphopenia and anemia are present. 
B) RBC production in bone marrow is increased. 
C) Release of RBCs to the peripheral blood is normal. 
D) RBC survival in circulation is less than 40 days. 
A) Lymphopenia and anemia are present. 
B) RBC production in bone marrow is increased. 
C) Release of RBCs to the peripheral blood is normal. 
D) RBC survival in circulation is less than 40 days. B

Question 4

Two different patients both have hemoglobins in the 5.0 to 6.0 g/dL range.One has pallor,fatigue,and headaches,whereas the other is experiencing life-threatening shock.Which of the following is probably the major difference between the two patients?

Accepted Answer

A) the morphologic classification of the anemia 
B) whether other cell lines (platelets or white cells) are also involved 
C) the patient's sex 
D) how quickly the anemia developed 
A) the morphologic classification of the anemia 
B) whether other cell lines (platelets or white cells) are also involved 
C) the patient's sex 
D) how quickly the anemia developed

Question 5

What test is used along with the mean cell volume (MCV)to morphologically classify anemias?

Accepted Answer

A) red blood count 
B) hemoglobin 
C) hematocrit 
D) RDW 
A) red blood count 
B) hemoglobin 
C) hematocrit 
D) RDW

Question 6

The reticulocyte response in patients with moderate anemia is often misinterpreted as adequate if:

Accepted Answer

A) the count is not expressed in absolute terms or corrected for anemia. 
B) the red cell indices are not considered. 
C) a bone marrow aspirate is not examined. 
D) red cell morphology is not considered. 
A) the count is not expressed in absolute terms or corrected for anemia. 
B) the red cell indices are not considered. 
C) a bone marrow aspirate is not examined. 
D) red cell morphology is not considered.

Question 7

Match the letter of the correct composition for the inclusion with the number for the inclusion.
Correct identification of inclusions in RBCs, when present, provides useful clinical information. They often help suggest the possible cause of an anemia and thus further appropriate testing. The first list provides some red cell inclusions. The second list provides choices for composition.
-Basophilic stippling

Accepted Answer

A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin 
A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin

Question 8

Describe the morphologic appearance of the red cells given the following results.
RBC: 1.89 × 10¹²/L
Hemoglobin: 7.5 g/dL
Hematocrit: 21.0%
RDW: 18.5

Accepted Answer

A) macrocytic with anisocytosis 
B) normocytic normochromic with anisocytosis 
C) microcytic hypochromic with little anisocytosis 
D) macrocytic with most cells the same size 
A) macrocytic with anisocytosis 
B) normocytic normochromic with anisocytosis 
C) microcytic hypochromic with little anisocytosis 
D) macrocytic with most cells the same size

Question 9

What is the best definition of anemia?

Accepted Answer

A) red cell count 10% lower than the patient's baseline 
B) decreased hemoglobin, hematocrit, and red cell count compared with healthy people in the same demographic group 
C) hemoglobin below 12 g/dL 
D) any clinical condition resulting in shortness of breath, increased heart rate, pallor, and fatigue 
A) red cell count 10% lower than the patient's baseline 
B) decreased hemoglobin, hematocrit, and red cell count compared with healthy people in the same demographic group 
C) hemoglobin below 12 g/dL 
D) any clinical condition resulting in shortness of breath, increased heart rate, pallor, and fatigue

Question 10

Which of the following is typically a macrocytic anemia?

Accepted Answer

A) thalassemia 
B) iron deficiency 
C) folate deficiency 
D) aplastic 
A) thalassemia 
B) iron deficiency 
C) folate deficiency 
D) aplastic

Question 11

Match the letter of the correct composition for the inclusion with the number for the inclusion.
Correct identification of inclusions in RBCs, when present, provides useful clinical information. They often help suggest the possible cause of an anemia and thus further appropriate testing. The first list provides some red cell inclusions. The second list provides choices for composition.
-Howell-Jolly body

Accepted Answer

A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin 
A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin

Question 12

The anemia found in liver disease is

Accepted Answer

A) macrocytic nonmegaloblastic. 
B) microcytic hypochromic. 
C) macrocytic megaloblastic. 
D) microcytic normochromic. 
A) macrocytic nonmegaloblastic. 
B) microcytic hypochromic. 
C) macrocytic megaloblastic. 
D) microcytic normochromic.

Question 13

Which of the following is an example of a morphologic classification of anemia?

Accepted Answer

A) normocytic normochromic 
B) loss of blood 
C) increased destruction 
D) impaired production 
A) normocytic normochromic 
B) loss of blood 
C) increased destruction 
D) impaired production

Question 14

Match the letter of the correct composition for the inclusion with the number for the inclusion.
Correct identification of inclusions in RBCs, when present, provides useful clinical information. They often help suggest the possible cause of an anemia and thus further appropriate testing. The first list provides some red cell inclusions. The second list provides choices for composition.
-Pappenheimer body

Accepted Answer

A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin 
A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin

Question 15

An appropriately increased RPI greater than 3 is associated with

Accepted Answer

A) iron deficiency anemia. 
B) macrocytic megaloblastic anemia. 
C) hemolytic anemia. 
D) sideroblastic anemia. 
A) iron deficiency anemia. 
B) macrocytic megaloblastic anemia. 
C) hemolytic anemia. 
D) sideroblastic anemia.

Question 16

Which of the following conditions would warrant a bone marrow aspiration?

Accepted Answer

A) iron deficiency in a patient with colon cancer 
B) severe hereditary spherocytosis 
C) disseminated intravascular coagulation (DI
C)  with very low hemoglobin and marked red cell fragments 
D) not possible to determine obvious reason for anemia 
A) iron deficiency in a patient with colon cancer 
B) severe hereditary spherocytosis 
C) disseminated intravascular coagulation (DI
C)  with very low hemoglobin and marked red cell fragments 
D) not possible to determine obvious reason for anemia

Question 17

All of the following are physiologic adaptations the body makes when a slow drop in the number of red cells occurs except

Accepted Answer

A) erythropoietin level increases. 
B) oxygen dissociation curve shifts to left. 
C) cardiac output increases. 
D) respiratory rate increases. 
A) erythropoietin level increases. 
B) oxygen dissociation curve shifts to left. 
C) cardiac output increases. 
D) respiratory rate increases.

Question 18

Match the letter of the correct composition for the inclusion with the number for the inclusion.
Correct identification of inclusions in RBCs, when present, provides useful clinical information. They often help suggest the possible cause of an anemia and thus further appropriate testing. The first list provides some red cell inclusions. The second list provides choices for composition.
-Heinz body

Accepted Answer

A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin 
A) Ferric nonheme iron 
B) Deoxyribonucleic acid (DN
A)  
C) Precipitated ribonucleic acid (RN
A)  
D) Denatured hemoglobin

Question 19

Which of the following is a microcytic anemia?

Accepted Answer

A) B12 deficiency 
B) sickle cell anemia 
C) iron deficiency 
D) hereditary spherocytosis 
A) B12 deficiency 
B) sickle cell anemia 
C) iron deficiency 
D) hereditary spherocytosis

Question 20

Which of the following red blood cell (RBC)findings is specific for a certain condition as opposed to being nonspecific and found in many conditions?

Accepted Answer

A) ovalocytes 
B) poikilocytosis 
C) sickle cells 
D) burr cells 
A) ovalocytes 
B) poikilocytosis 
C) sickle cells 
D) burr cells

Exam 19: Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Which of the following disorders would be consistent with the previously mentioned parameters?

What is the approximate average life span of a normal RBC in circulation?

Which of the following is true of ineffective erythropoiesis?

Two different patients both have hemoglobins in the 5.0 to 6.0 g/dL range.One has pallor,fatigue,and headaches,whereas the other is experiencing life-threatening shock.Which of the following is probably the major difference between the two patients?

What test is used along with the mean cell volume (MCV)to morphologically classify anemias?

The reticulocyte response in patients with moderate anemia is often misinterpreted as adequate if:

Describe the morphologic appearance of the red cells given the following results. RBC: 1.89 × 10¹²/L Hemoglobin: 7.5 g/dL Hematocrit: 21.0% RDW: 18.5

What is the best definition of anemia?

Which of the following is typically a macrocytic anemia?

The anemia found in liver disease is

Which of the following is an example of a morphologic classification of anemia?

An appropriately increased RPI greater than 3 is associated with

Which of the following conditions would warrant a bone marrow aspiration?

All of the following are physiologic adaptations the body makes when a slow drop in the number of red cells occurs except

Which of the following is a microcytic anemia?

Which of the following red blood cell (RBC)findings is specific for a certain condition as opposed to being nonspecific and found in many conditions?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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