Question 1

Which of the following is a hematopoietic growth factor?

Accepted Answer

A) interleukin 
B) BFU-E 
C) fibroblast 
D) HSC 
A) interleukin 
B) BFU-E 
C) fibroblast 
D) HSC A

Question 2

All of the following functions are performed by cytokines except

Accepted Answer

A) stimulating production of blood cells. 
B) inducing macrophages to attack senescent cells. 
C) regulating cell differentiation. 
D) monitoring trafficking of mature blood cells. 
A) stimulating production of blood cells. 
B) inducing macrophages to attack senescent cells. 
C) regulating cell differentiation. 
D) monitoring trafficking of mature blood cells. B

Question 3

What bone marrow cells can differentiate into all of the blood cells?

Accepted Answer

A) burst-forming unit-erythroid (BFU-
E)  
B) colony-forming unit-granulocyte-monocyte (CFU-GM) 
C) colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM) 
D) hematopoietic stem cells (HSCs) 
A) burst-forming unit-erythroid (BFU-
E)  
B) colony-forming unit-granulocyte-monocyte (CFU-GM) 
C) colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM) 
D) hematopoietic stem cells (HSCs) D

Question 4

Germinal centers in lymph nodes contain primarily

Accepted Answer

A) B cells. 
B) macrophages. 
C) neutrophils. 
D) T cells. 
A) B cells. 
B) macrophages. 
C) neutrophils. 
D) T cells.

Question 5

What is the primary mechanism for the anemia associated with kidney disease?

Accepted Answer

A) hemolysis 
B) hemorrhage 
C) inadequate synthesis of erythropoietin 
D) inadequate synthesis of interleukins 
A) hemolysis 
B) hemorrhage 
C) inadequate synthesis of erythropoietin 
D) inadequate synthesis of interleukins

Question 6

Kupffer cells,found in the liver,are

Accepted Answer

A) adipose cells. 
B) macrophages. 
C) immature red cells. 
D) immature granulocytes (neutrophils). 
A) adipose cells. 
B) macrophages. 
C) immature red cells. 
D) immature granulocytes (neutrophils).

Question 7

Why does surgical removal of the spleen cause people to have an increased platelet count?

Accepted Answer

A) The bone marrow makes more platelets when the person has no spleen. 
B) The 30% of platelets normally stored in the spleen are freely circulating. 
C) Antibodies produced after splenectomy attack platelets. 
D) Surgery stimulates platelet growth factors. 
A) The bone marrow makes more platelets when the person has no spleen. 
B) The 30% of platelets normally stored in the spleen are freely circulating. 
C) Antibodies produced after splenectomy attack platelets. 
D) Surgery stimulates platelet growth factors.

Question 8

Apoptosis is

Accepted Answer

A) enhanced red cell production. 
B) programmed cell death. 
C) directed exit of cells from the bone marrow. 
D) accidental cell death from trauma. 
A) enhanced red cell production. 
B) programmed cell death. 
C) directed exit of cells from the bone marrow. 
D) accidental cell death from trauma.

Question 9

How do cells get from the bone marrow into peripheral circulation?

Accepted Answer

A) Stem cells escape the bone marrow and mature in peripheral circulation. 
B) Mature cells attach to a carrier protein for transport. 
C) Capillaries flow into the marrow and pluck out precursor cells. 
D) Mature cells squeeze through spaces in the vessel endothelial lining. 
A) Stem cells escape the bone marrow and mature in peripheral circulation. 
B) Mature cells attach to a carrier protein for transport. 
C) Capillaries flow into the marrow and pluck out precursor cells. 
D) Mature cells squeeze through spaces in the vessel endothelial lining.

Question 10

Where are developing red cells located in the bone marrow?

Accepted Answer

A) adjacent to the outer surfaces of the vascular sinuses 
B) outside the vascular walls of the sinusoids 
C) deep in the cords 
D) randomly spaced throughout the cords 
A) adjacent to the outer surfaces of the vascular sinuses 
B) outside the vascular walls of the sinusoids 
C) deep in the cords 
D) randomly spaced throughout the cords

Question 11

How many blood cells are made each day in the bone marrow of a normal adult?

Accepted Answer

A) thousands 
B) millions 
C) about 1 billion 
D) hundreds of billions 
A) thousands 
B) millions 
C) about 1 billion 
D) hundreds of billions

Question 12

Enlarged lymph nodes are commonly found in all of the following except

Accepted Answer

A) viral infections. 
B) liver cirrhosis. 
C) bacterial infections. 
D) metastatic malignancy. 
A) viral infections. 
B) liver cirrhosis. 
C) bacterial infections. 
D) metastatic malignancy.

Question 13

All of the following are functions of macrophages in the bone marrow except

Accepted Answer

A) activating adipose cells. 
B) secreting cytokines. 
C) storing iron. 
D) phagocytizing senescent cells. 
A) activating adipose cells. 
B) secreting cytokines. 
C) storing iron. 
D) phagocytizing senescent cells.

Question 14

What are the major hematopoietic sites in the fetus and in the adult?
FetusAdult

Accepted Answer

A) lymph node spleen 
B) liver bone marrow 
C) liver spleen 
D) bone marrow liver 
A) lymph node spleen 
B) liver bone marrow 
C) liver spleen 
D) bone marrow liver

Question 15

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?

Accepted Answer

A) Blood loss from surgery increases erythrocyte production. 
B) Necessary hematopoiesis growth factors produced in the spleen are lost. 
C) Removal of the spleen induces the formation of inclusions. 
D) The absent spleen cannot "pit" or remove the normally formed inclusions. 
A) Blood loss from surgery increases erythrocyte production. 
B) Necessary hematopoiesis growth factors produced in the spleen are lost. 
C) Removal of the spleen induces the formation of inclusions. 
D) The absent spleen cannot "pit" or remove the normally formed inclusions.

Question 16

Which of the following,using Wright stain,is a feature of normal cells as they mature?

Accepted Answer

A) overall size increases 
B) nucleoli become more prominent 
C) nuclear chromatin becomes more condensed 
D) cytoplasmic basophilia increases 
A) overall size increases 
B) nucleoli become more prominent 
C) nuclear chromatin becomes more condensed 
D) cytoplasmic basophilia increases

Question 17

The thymus is responsible for the initial development of

Accepted Answer

A) macrophages. 
B) T cells. 
C) B cells. 
D) neutrophils. 
A) macrophages. 
B) T cells. 
C) B cells. 
D) neutrophils.

Question 18

Which of the following is a morphologically identifiable precursor cell using Wright stain?

Accepted Answer

A) promyelocyte 
B) colony-forming unit-erythrocyte (cfu-e) 
C) colony-stimulating factor-granulocyte-monocyte (CSF-GM) 
D) HSC 
A) promyelocyte 
B) colony-forming unit-erythrocyte (cfu-e) 
C) colony-stimulating factor-granulocyte-monocyte (CSF-GM) 
D) HSC

Question 19

What condition is most associated with autosplenectomy?

Accepted Answer

A) abdominal trauma 
B) thrombocytopenia 
C) sickle cell anemia 
D) iron deficiency 
A) abdominal trauma 
B) thrombocytopenia 
C) sickle cell anemia 
D) iron deficiency

Question 20

Colony-stimulating factors

Accepted Answer

A) have poor affinity for their target cells. 
B) require high concentrations to be effective. 
C) are produced by many cells. 
D) are all lineage specific. 
A) have poor affinity for their target cells. 
B) require high concentrations to be effective. 
C) are produced by many cells. 
D) are all lineage specific.

Exam 7: Hematopoiesis

Which of the following is a hematopoietic growth factor?

All of the following functions are performed by cytokines except

What bone marrow cells can differentiate into all of the blood cells?

Germinal centers in lymph nodes contain primarily

What is the primary mechanism for the anemia associated with kidney disease?

Kupffer cells,found in the liver,are

Why does surgical removal of the spleen cause people to have an increased platelet count?

Apoptosis is

How do cells get from the bone marrow into peripheral circulation?

Where are developing red cells located in the bone marrow?

How many blood cells are made each day in the bone marrow of a normal adult?

Enlarged lymph nodes are commonly found in all of the following except

All of the following are functions of macrophages in the bone marrow except

What are the major hematopoietic sites in the fetus and in the adult? FetusAdult

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?

Which of the following,using Wright stain,is a feature of normal cells as they mature?

The thymus is responsible for the initial development of

Which of the following is a morphologically identifiable precursor cell using Wright stain?

What condition is most associated with autosplenectomy?

Colony-stimulating factors

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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