Question 1

What is the best method for detecting chromosomal material that has been structurally altered?

Accepted Answer

A) fluorescence in situ hybridization (FISH) 
B) G banding 
C) Q banding 
D) Ag-NOR banding 
A) fluorescence in situ hybridization (FISH) 
B) G banding 
C) Q banding 
D) Ag-NOR banding A

Question 2

All of the following disorders are associated with acquired chromosome abnormalities except

Accepted Answer

A) megaloblastic anemia. 
B) chronic myelogenous leukemia. 
C) acute myeloid leukemia. 
D) acute lymphoblastic leukemia. 
A) megaloblastic anemia. 
B) chronic myelogenous leukemia. 
C) acute myeloid leukemia. 
D) acute lymphoblastic leukemia. A

Question 3

How many chromosomes does a human with triploidy have?

Accepted Answer

A) 3 
B) 23 
C) 47 
D) 69 
A) 3 
B) 23 
C) 47 
D) 69 D

Question 4

Cell division to produce daughter cells identical to the parent cell is an example of

Accepted Answer

A) nondisjunction. 
B) meiosis. 
C) mitosis. 
D) gamete production. 
A) nondisjunction. 
B) meiosis. 
C) mitosis. 
D) gamete production.

Question 5

A patient has a hematologic malignancy.Karyotyping is performed for all of the following reasons except

Accepted Answer

A) to provide unique cytogenetic profile to confirm the patient's identification. 
B) to provide diagnostic information. 
C) to identify whether the patient will respond to appropriate therapy. 
D) to provide prognostic information. 
A) to provide unique cytogenetic profile to confirm the patient's identification. 
B) to provide diagnostic information. 
C) to identify whether the patient will respond to appropriate therapy. 
D) to provide prognostic information.

Question 6

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

Accepted Answer

A) trisomy 8 
B) deletion 7 
C) Philadelphia 
D) isocentric chromosome 16 
A) trisomy 8 
B) deletion 7 
C) Philadelphia 
D) isocentric chromosome 16

Question 7

A break in two chromosomes with each piece uniting with different chromosomes is called

Accepted Answer

A) deletion. 
B) duplication. 
C) insertion. 
D) translocation. 
A) deletion. 
B) duplication. 
C) insertion. 
D) translocation.

Question 8

What happens to nuclear chromatin at mitosis?

Accepted Answer

A) opens 
B) condenses 
C) disappears 
D) develops nucleoli 
A) opens 
B) condenses 
C) disappears 
D) develops nucleoli

Question 9

Cytogenetics is performed on the bone marrow of a patient,and 20 cells are examined.The patient's karyotype is reported as 47,XX,+7(14),indicating that

Accepted Answer

A) this is a female patient with trisomy chromosome 7 found in 14 of the cells examined. 
B) this is a female patient with monosomy chromosome 7 found in 1 of 4 cells examined. 
C) this is a male patient with trisomy 7 found in 1 of 4 cells examined. 
D) this is a male patient with monosomy 7 found in 14 of the cells examined. 
A) this is a female patient with trisomy chromosome 7 found in 14 of the cells examined. 
B) this is a female patient with monosomy chromosome 7 found in 1 of 4 cells examined. 
C) this is a male patient with trisomy 7 found in 1 of 4 cells examined. 
D) this is a male patient with monosomy 7 found in 14 of the cells examined.

Question 10

All of the following samples are commonly analyzed for chromosomes except

Accepted Answer

A) bone marrow. 
B) amniotic fluid. 
C) peripheral lymphocytes. 
D) tissue with a low mitotic rate. 
A) bone marrow. 
B) amniotic fluid. 
C) peripheral lymphocytes. 
D) tissue with a low mitotic rate.

Question 11

Nonrandom chromosomal abnormalities are

Accepted Answer

A) congenital chromosome abnormalities that are consistently found in all tissues of an affected individual. 
B) acquired chromosome abnormalities that are found in the abnormal or malignant tissue of an affected individual. 
C) acquired chromosome abnormalities that are found in all tissues of an affected individual. 
D) congenital chromosome abnormalities that are found in only one type of tissue of an affected individual. 
A) congenital chromosome abnormalities that are consistently found in all tissues of an affected individual. 
B) acquired chromosome abnormalities that are found in the abnormal or malignant tissue of an affected individual. 
C) acquired chromosome abnormalities that are found in all tissues of an affected individual. 
D) congenital chromosome abnormalities that are found in only one type of tissue of an affected individual.

Question 12

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

Accepted Answer

A) sexual ambiguity 
B) myeloid leukemia 
C) mental retardation 
D) usually incompatible with life 
A) sexual ambiguity 
B) myeloid leukemia 
C) mental retardation 
D) usually incompatible with life

Question 13

The period in the cell cycle when deoxyribonucleic acid (DNA)is synthesized is

Accepted Answer

A) G1 
B) S 
C) G2 
D) M 
A) G1 
B) S 
C) G2 
D) M

Question 14

A chromosome number that is not a multiple of the haploid number is

Accepted Answer

A) aneuploidy. 
B) mosaic. 
C) polyploidy. 
D) incompatible with life. 
A) aneuploidy. 
B) mosaic. 
C) polyploidy. 
D) incompatible with life.

Question 15

Where is a gene designated 9p23 located?

Accepted Answer

A) short arm of chromosome 23, region 9 
B) long arm of chromosome 3, region 2, band 9 
C) short arm of chromosome 9, region 2, band 3 
D) on the translocated part of chromosome 9 on chromosome 23 
A) short arm of chromosome 23, region 9 
B) long arm of chromosome 3, region 2, band 9 
C) short arm of chromosome 9, region 2, band 3 
D) on the translocated part of chromosome 9 on chromosome 23

Question 16

Which of the following is true regarding the number of chromosomes of different species?

Accepted Answer

A) All mammals have the same number. 
B) Numbers vary greatly among mammals unrelated to characteristics. 
C) Primates have more than lower mammals. 
D) Primates have fewer than lower mammals. 
A) All mammals have the same number. 
B) Numbers vary greatly among mammals unrelated to characteristics. 
C) Primates have more than lower mammals. 
D) Primates have fewer than lower mammals.

Question 17

What tissue is most often studied for hematologic malignancies?

Accepted Answer

A) peripheral blood 
B) bone marrow 
C) spleen 
D) lymph node sections 
A) peripheral blood 
B) bone marrow 
C) spleen 
D) lymph node sections

Exam 30: Cytogenetics

What is the best method for detecting chromosomal material that has been structurally altered?

All of the following disorders are associated with acquired chromosome abnormalities except

How many chromosomes does a human with triploidy have?

Cell division to produce daughter cells identical to the parent cell is an example of

A patient has a hematologic malignancy.Karyotyping is performed for all of the following reasons except

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

A break in two chromosomes with each piece uniting with different chromosomes is called

What happens to nuclear chromatin at mitosis?

Cytogenetics is performed on the bone marrow of a patient,and 20 cells are examined.The patient's karyotype is reported as 47,XX,+7(14),indicating that

All of the following samples are commonly analyzed for chromosomes except

Nonrandom chromosomal abnormalities are

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

The period in the cell cycle when deoxyribonucleic acid (DNA)is synthesized is

A chromosome number that is not a multiple of the haploid number is

Where is a gene designated 9p23 located?

Which of the following is true regarding the number of chromosomes of different species?

What tissue is most often studied for hematologic malignancies?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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