Question 1

Which of the following is the best test to distinguish iron deficiency anemia from ACI?

Accepted Answer

A) serum iron 
B) hemoglobin 
C) free erythrocyte protoporphyrin (FEP) 
D) ferritin 
A) serum iron 
B) hemoglobin 
C) free erythrocyte protoporphyrin (FEP) 
D) ferritin D

Question 2

Ringed sideroblasts are a reflection of iron-laden

Accepted Answer

A) mitochondria. 
B) Golgi complex. 
C) ribosomes. 
D) rough endoplasmic reticulum. 
A) mitochondria. 
B) Golgi complex. 
C) ribosomes. 
D) rough endoplasmic reticulum. A

Question 3

Why is too much iron dangerous?

Accepted Answer

A) Transferrin, which carries iron, causes cellular swelling and lysis. 
B) The oxygen carried by excess iron oxidizes neurologic cells. 
C) Iron's breakdown products cause excretion of vitamins C and E. 
D) Free radicals and superoxide formed from ferrous iron plus oxygen damage cell membranes. 
A) Transferrin, which carries iron, causes cellular swelling and lysis. 
B) The oxygen carried by excess iron oxidizes neurologic cells. 
C) Iron's breakdown products cause excretion of vitamins C and E. 
D) Free radicals and superoxide formed from ferrous iron plus oxygen damage cell membranes. D

Question 4

What would be the likely findings if a bone marrow aspiration were performed in a complicated case of iron deficiency anemia?

Accepted Answer

A) increased myeloid-to-erythroid (M:
E)  ratio and increased staining with Prussian blue 
B) shaggy polychromatophilic normoblasts and no staining with Prussian blue 
C) polychromatophilic normoblasts with copious pink cytoplasm and no staining with Prussian blue 
D) increased M:E ratio and increased ringed sideroblasts 
A) increased myeloid-to-erythroid (M:
E)  ratio and increased staining with Prussian blue 
B) shaggy polychromatophilic normoblasts and no staining with Prussian blue 
C) polychromatophilic normoblasts with copious pink cytoplasm and no staining with Prussian blue 
D) increased M:E ratio and increased ringed sideroblasts

Question 5

How does lead exposure and the porphyrias cause anemia?

Accepted Answer

A) cause destruction of red cells 
B) chelate iron from the body 
C) impair iron absorption 
D) interfere with heme production 
A) cause destruction of red cells 
B) chelate iron from the body 
C) impair iron absorption 
D) interfere with heme production

Question 6

Transfusion-related hemochromatosis is seen in patients who

Accepted Answer

A) had an adverse reaction to a blood transfusion. 
B) received the wrong type of blood. 
C) had lifelong repeated red cell transfusions. 
D) received a transfusion from a relative. 
A) had an adverse reaction to a blood transfusion. 
B) received the wrong type of blood. 
C) had lifelong repeated red cell transfusions. 
D) received a transfusion from a relative.

Question 7

Which of the following groups is least likely to develop iron deficiency?

Accepted Answer

A) infants 
B) young men 
C) teenage girls 
D) adult premenopausal women 
A) infants 
B) young men 
C) teenage girls 
D) adult premenopausal women

Question 8

Which of the following results is or are typical in stage 3 iron deficiency anemia?

Accepted Answer

A) elevated reticulocyte percentage 
B) thrombocytopenia 
C) macrocytic red cells 
D) low mean cell volume (MCV), MCH, and mean cell hemoglobin concentration (MCH
C)  
A) elevated reticulocyte percentage 
B) thrombocytopenia 
C) macrocytic red cells 
D) low mean cell volume (MCV), MCH, and mean cell hemoglobin concentration (MCH
C)

Question 9

Most of the clinical findings in the porphyrias are related to

Accepted Answer

A) accumulated porphyrin compounds in tissue. 
B) anemia. 
C) reduction in heme production. 
D) iron being unavailable. 
A) accumulated porphyrin compounds in tissue. 
B) anemia. 
C) reduction in heme production. 
D) iron being unavailable.

Question 10

What is the mechanism for ACI?

Accepted Answer

A) Acute phase reactants impair iron mobilization. 
B) Inflammation and infections slow heme development. 
C) Cytokines prevent iron incorporation into protoporphyrin. 
D) Bone marrow iron stores are depleted by acute phase reactants. 
A) Acute phase reactants impair iron mobilization. 
B) Inflammation and infections slow heme development. 
C) Cytokines prevent iron incorporation into protoporphyrin. 
D) Bone marrow iron stores are depleted by acute phase reactants.

Question 11

Why is lead poisoning of particular concern in children?

Accepted Answer

A) Severe anemia may develop. 
B) Impaired mental development may occur. 
C) Secondary iron deficiency may develop. 
D) FEP may accumulate. 
A) Severe anemia may develop. 
B) Impaired mental development may occur. 
C) Secondary iron deficiency may develop. 
D) FEP may accumulate.

Question 12

What is most likely if a 10-month-old child fed only cow's milk has the following results?
· Serum iron decreased
· Total iron-binding capacity (TIBC)increased
· Ferritin decreased

Accepted Answer

A) lead poisoning 
B) chronic disease 
C) iron deficiency from increased need and inadequate diet 
D) iron deficiency from chronic blood loss 
A) lead poisoning 
B) chronic disease 
C) iron deficiency from increased need and inadequate diet 
D) iron deficiency from chronic blood loss

Question 13

Ringed sideroblasts are seen in

Accepted Answer

A) inherited sideroblastic anemia. 
B) acquired hemochromatosis. 
C) iron deficiency anemia. 
D) ACI. 
A) inherited sideroblastic anemia. 
B) acquired hemochromatosis. 
C) iron deficiency anemia. 
D) ACI.

Question 14

Which of the following is decreased in patients with hereditary hemochromatosis?

Accepted Answer

A) albumin 
B) serum iron 
C) transferrin saturation 
D) ferritin 
A) albumin 
B) serum iron 
C) transferrin saturation 
D) ferritin

Question 15

Which of the following characterizes stage 1 iron deficiency?
AnemiaMCVFerritin

Accepted Answer

A) Present Decreased Decreased 
B) Present Normal Normal 
C) Absent Normal Decreased 
D) Absent Decreased Normal 
A) Present Decreased Decreased 
B) Present Normal Normal 
C) Absent Normal Decreased 
D) Absent Decreased Normal

Question 16

All of the following are true about hepcidin except that

Accepted Answer

A) it is an acute phase protein. 
B) it is a hormone. 
C) it decreases in response to increased ferritin. 
D) it increases in response to increased iron stores. 
A) it is an acute phase protein. 
B) it is a hormone. 
C) it decreases in response to increased ferritin. 
D) it increases in response to increased iron stores.

Question 17

Which of the following red cell inclusions is or are often found in lead poisoning?

Accepted Answer

A) Howell-Jolly bodies 
B) basophilic stippling 
C) Heinz bodies 
D) Cabot rings 
A) Howell-Jolly bodies 
B) basophilic stippling 
C) Heinz bodies 
D) Cabot rings

Question 18

Where is most of the iron in the body found?

Accepted Answer

A) attached to hemoglobin in the red blood cells (RBCs) 
B) stored in macrophages in the bone marrow 
C) attached to transferrin 
D) myoglobin 
A) attached to hemoglobin in the red blood cells (RBCs) 
B) stored in macrophages in the bone marrow 
C) attached to transferrin 
D) myoglobin

Question 19

Which of the following promotes increased iron absorption?

Accepted Answer

A) repeated phlebotomy 
B) eating iron-rich foods along with those high in ascorbic acid 
C) desferrioxamine 
D) vegetarian diet 
A) repeated phlebotomy 
B) eating iron-rich foods along with those high in ascorbic acid 
C) desferrioxamine 
D) vegetarian diet

Question 20

Which of following are typical laboratory results for ACI?

Accepted Answer

A) decreased ferritin and decreased bone marrow Prussian blue staining 
B) low serum iron and high TIBC 
C) low serum iron and low TIBC 
D) increased transferrin saturation and decreased FEP 
A) decreased ferritin and decreased bone marrow Prussian blue staining 
B) low serum iron and high TIBC 
C) low serum iron and low TIBC 
D) increased transferrin saturation and decreased FEP

Exam 20: Disorders of Iron Kinetics and Heme Metabolism

Which of the following is the best test to distinguish iron deficiency anemia from ACI?

Ringed sideroblasts are a reflection of iron-laden

Why is too much iron dangerous?

What would be the likely findings if a bone marrow aspiration were performed in a complicated case of iron deficiency anemia?

How does lead exposure and the porphyrias cause anemia?

Transfusion-related hemochromatosis is seen in patients who

Which of the following groups is least likely to develop iron deficiency?

Which of the following results is or are typical in stage 3 iron deficiency anemia?

Most of the clinical findings in the porphyrias are related to

What is the mechanism for ACI?

Why is lead poisoning of particular concern in children?

What is most likely if a 10-month-old child fed only cow's milk has the following results? · Serum iron decreased · Total iron-binding capacity (TIBC)increased · Ferritin decreased

Ringed sideroblasts are seen in

Which of the following is decreased in patients with hereditary hemochromatosis?

Which of the following characterizes stage 1 iron deficiency? AnemiaMCVFerritin

All of the following are true about hepcidin except that

Which of the following red cell inclusions is or are often found in lead poisoning?

Where is most of the iron in the body found?

Which of the following promotes increased iron absorption?

Which of following are typical laboratory results for ACI?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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