Question 1

What are the abnormal cytoplasmic inclusions in Chédiak-Higashi?

Accepted Answer

A) nuclear fragments that prevent cell division 
B) ribosomal material that looks like Döhle bodies 
C) fused granules that inhibit bactericidal functions 
D) mucopolysaccharide lipids that disrupt cell function 
A) nuclear fragments that prevent cell division 
B) ribosomal material that looks like Döhle bodies 
C) fused granules that inhibit bactericidal functions 
D) mucopolysaccharide lipids that disrupt cell function C

Question 2

A patient has a white count of 15.0 × 10⁹/L.What is the correct interpretation?

Accepted Answer

A) normal for an infant, leukocytosis for an adult 
B) normal for an infant, leukemoid reaction for an adult 
C) leukocytosis for any patient 
D) normal for any patient 
A) normal for an infant, leukocytosis for an adult 
B) normal for an infant, leukemoid reaction for an adult 
C) leukocytosis for any patient 
D) normal for any patient A

Question 3

A chemotherapy patient's white blood cell (WBC)count is 1.0 × 10⁹ /L.There are 60% segmented neutrophils,38% lymphocytes,and 2% monocytes.What is the correct interpretation of the relative differential?

Accepted Answer

A) normal 
B) neutrophilia 
C) neutropenia 
D) lymphopenia 
A) normal 
B) neutrophilia 
C) neutropenia 
D) lymphopenia A

Question 4

Which of the following is the poorest prognostic sign for a patient with a bacterial infection?

Accepted Answer

A) high white count with mature neutrophils 
B) high white count with immature neutrophils 
C) high white count with few toxic changes in neutrophils 
D) low white count with immature neutrophils and toxic changes 
A) high white count with mature neutrophils 
B) high white count with immature neutrophils 
C) high white count with few toxic changes in neutrophils 
D) low white count with immature neutrophils and toxic changes

Question 5

A patient has a white count of 8.3 × 10⁹/L and 65% lymphocytes.What is the correct interpretation?

Accepted Answer

A) depends on the patient's age 
B) lymphocytosis 
C) lymphopenia 
D) patient probably has infectious mononucleosis 
A) depends on the patient's age 
B) lymphocytosis 
C) lymphopenia 
D) patient probably has infectious mononucleosis

Question 6

Deficient enzymes that allow various lipids to accumulate in macrophages and monocytes describes

Accepted Answer

A) chronic granulomatous disease. 
B) congenital C3 deficiencies. 
C) storage cell diseases. 
D) familial hyperlipidemia disorders. 
A) chronic granulomatous disease. 
B) congenital C3 deficiencies. 
C) storage cell diseases. 
D) familial hyperlipidemia disorders.

Question 7

Nuclear hyposegmentation and denser than normal chromatin clumping are features of

Accepted Answer

A) Alder-Reilly anomaly. 
B) Chédiak-Higashi syndrome. 
C) May-Hegglin anomaly. 
D) Pelger-Huët anomaly. 
A) Alder-Reilly anomaly. 
B) Chédiak-Higashi syndrome. 
C) May-Hegglin anomaly. 
D) Pelger-Huët anomaly.

Question 8

A chemotherapy patient's WBC count is 1.0 × 10⁹ /L.There are 60% segmented neutrophils,38% lymphocytes,and 2% monocytes.What is the absolute neutrophil count?

Accepted Answer

A) 60 × 109/L 
B) 6 × 109/L 
C) 0.6 × 109/L 
D) 0.16 × 109/L 
A) 60 × 109/L 
B) 6 × 109/L 
C) 0.6 × 109/L 
D) 0.16 × 109/L

Question 9

A clinical laboratory scientist sees unusual,darkly stained cytoplasmic inclusions in leukocytes that she has not seen before.She should

Accepted Answer

A) ignore them; they probably are not significant. 
B) report that the patient has Alder-Reilly anomaly. 
C) report toxic granulation if the patient is known to have an infection. 
D) have a supervisor or pathologist look at the cells. 
A) ignore them; they probably are not significant. 
B) report that the patient has Alder-Reilly anomaly. 
C) report toxic granulation if the patient is known to have an infection. 
D) have a supervisor or pathologist look at the cells.

Question 10

Nonmalignant disorders of leukocytes are

Accepted Answer

A) inherited and cause no symptoms. 
B) acquired and cause serious disease. 
C) acquired and affect the nuclei of cells. 
D) acquired or inherited and range from benign to life threatening. 
A) inherited and cause no symptoms. 
B) acquired and cause serious disease. 
C) acquired and affect the nuclei of cells. 
D) acquired or inherited and range from benign to life threatening.

Question 11

Neutrophilia and a left shift are most often found in patients with

Accepted Answer

A) autoimmune disorder. 
B) acute bacterial infection. 
C) hemolytic anemia. 
D) acute viral infection. 
A) autoimmune disorder. 
B) acute bacterial infection. 
C) hemolytic anemia. 
D) acute viral infection.

Question 12

The nitroblue tetrazolium test is used to diagnose

Accepted Answer

A) chronic granulomatous disease. 
B) Pelger-Huët anomaly. 
C) May-Hegglin anomaly. 
D) necrobiosis. 
A) chronic granulomatous disease. 
B) Pelger-Huët anomaly. 
C) May-Hegglin anomaly. 
D) necrobiosis.

Question 13

A college student seeks medical care for extreme fatigue and swollen lymph nodes in the neck.The WBC count is 11.3 × 10⁹/L.The differential shows a relative and absolute lymphocytosis.Many of the lymphocytes are larger than normal,with a basophilic cytoplasm indented by the red blood cells (RBCs).The nuclei are less clumped than normal and some have nucleoli.The rest of the complete blood count (CBC)is normal.What is the most likely diagnosis?

Accepted Answer

A) infectious lymphocytosis 
B) infectious mononucleosis 
C) lymphoma 
D) lymphocytic leukemia 
A) infectious lymphocytosis 
B) infectious mononucleosis 
C) lymphoma 
D) lymphocytic leukemia

Question 14

Neutrophilia accompanied by immature granulocytes and nucleated red cells is what kind of reaction?

Accepted Answer

A) leukoerythroblastic 
B) leukemoid 
C) myelophthisic 
D) myeloproliferative 
A) leukoerythroblastic 
B) leukemoid 
C) myelophthisic 
D) myeloproliferative

Question 15

The Epstein-Barr virus is the causative agent for

Accepted Answer

A) infectious mononucleosis. 
B) infectious lymphocytosis. 
C) lymphocytic leukemia. 
D) monocytic leukemia. 
A) infectious mononucleosis. 
B) infectious lymphocytosis. 
C) lymphocytic leukemia. 
D) monocytic leukemia.

Question 16

A patient has 20% eosinophils.Which of the following can probably be eliminated?

Accepted Answer

A) allergy 
B) parasitic infection 
C) pertussis 
D) chronic myelogenous leukemia 
A) allergy 
B) parasitic infection 
C) pertussis 
D) chronic myelogenous leukemia

Question 17

What is the concern if Pelger-Huët anomaly is not recognized?

Accepted Answer

A) Without treatment, the patient will probably die. 
B) The cells could be misclassified as immature neutrophils, indicating that the patient has a bacterial infection when he or she does not. 
C) The patient could develop pseudo-Pelger-Huët followed by leukemia. 
D) The cells could be misclassified as blasts, indicating that the patient has acute leukemia when he or she does not. 
A) Without treatment, the patient will probably die. 
B) The cells could be misclassified as immature neutrophils, indicating that the patient has a bacterial infection when he or she does not. 
C) The patient could develop pseudo-Pelger-Huët followed by leukemia. 
D) The cells could be misclassified as blasts, indicating that the patient has acute leukemia when he or she does not.

Question 18

Gaucher cells and Niemann-Pick cells are found in

Accepted Answer

A) peripheral blood. 
B) bone marrow only. 
C) spleen only. 
D) bone marrow and spleen. 
A) peripheral blood. 
B) bone marrow only. 
C) spleen only. 
D) bone marrow and spleen.

Question 19

Most often the clinician makes a diagnosis of infectious mononucleosis by which of the following findings?

Accepted Answer

A) significant lymphocytosis, with reactive lymphocytes predominating 
B) presence of mild thrombocytopenia, with a significant lymphocytosis 
C) demonstration of the presence of the heterophil antibody 
D) demonstration of the presence of cytomegalovirus antibody 
A) significant lymphocytosis, with reactive lymphocytes predominating 
B) presence of mild thrombocytopenia, with a significant lymphocytosis 
C) demonstration of the presence of the heterophil antibody 
D) demonstration of the presence of cytomegalovirus antibody

Question 20

A patient has a white count of 15.0 × 10⁹/L.What is the best test to determine the reason for the leukocyte count?

Accepted Answer

A) bacterial cultures 
B) white cell differential 
C) bone marrow aspirate 
D) serologic test for infectious mononucleosis 
A) bacterial cultures 
B) white cell differential 
C) bone marrow aspirate 
D) serologic test for infectious mononucleosis

Exam 29: Nonmalignant Leukocyte Disorders

What are the abnormal cytoplasmic inclusions in Chédiak-Higashi?

A patient has a white count of 15.0 × 10⁹/L.What is the correct interpretation?

A chemotherapy patient's white blood cell (WBC)count is 1.0 × 10⁹ /L.There are 60% segmented neutrophils,38% lymphocytes,and 2% monocytes.What is the correct interpretation of the relative differential?

Which of the following is the poorest prognostic sign for a patient with a bacterial infection?

A patient has a white count of 8.3 × 10⁹/L and 65% lymphocytes.What is the correct interpretation?

Deficient enzymes that allow various lipids to accumulate in macrophages and monocytes describes

Nuclear hyposegmentation and denser than normal chromatin clumping are features of

A chemotherapy patient's WBC count is 1.0 × 10⁹ /L.There are 60% segmented neutrophils,38% lymphocytes,and 2% monocytes.What is the absolute neutrophil count?

A clinical laboratory scientist sees unusual,darkly stained cytoplasmic inclusions in leukocytes that she has not seen before.She should

Nonmalignant disorders of leukocytes are

Neutrophilia and a left shift are most often found in patients with

The nitroblue tetrazolium test is used to diagnose

Neutrophilia accompanied by immature granulocytes and nucleated red cells is what kind of reaction?

The Epstein-Barr virus is the causative agent for

A patient has 20% eosinophils.Which of the following can probably be eliminated?

What is the concern if Pelger-Huët anomaly is not recognized?

Gaucher cells and Niemann-Pick cells are found in

Most often the clinician makes a diagnosis of infectious mononucleosis by which of the following findings?

A patient has a white count of 15.0 × 10⁹/L.What is the best test to determine the reason for the leukocyte count?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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