Question 1

The urea solubility test is used to detect deficiencies in which factor?

Accepted Answer

A) fibrinogen 
B) factor V 
C) factor XII 
D) factor XIII 
A) fibrinogen 
B) factor V 
C) factor XII 
D) factor XIII

Question 2

Clot-based mixing studies and Bethesda titers are used to test for

Accepted Answer

A) vitamin K deficiency 
B) inhibitors (antibodies) against coagulation factors 
C) DIC 
D) hemophilia 
A) vitamin K deficiency 
B) inhibitors (antibodies) against coagulation factors 
C) DIC 
D) hemophilia

Question 3

A 21-year-old woman has a primary complaint of menorrhagia.Her coagulation screen gives the following results.
$\begin{array}{lll}
\underline { \text { Test  }}&\underline { \text { Test Result }}& \underline { \text { Reference range }}\
\text { Prothrombin time (PT) } & 12.0 \text { seconds } & 11-15 \text { seconds } \
\text { Partial thromboplastin time (PTT) } & 40 \text { seconds } & 25-37 \text { seconds } \
\text { Factor VII activity } & 35 \% & 50 \%-150 \% \
\text { Platelet count } & 275 \times {10}^{9} / \mathrm{L} & 150-400 \times {10}^{9} / \mathrm{L} .
\end{array}$
What disorder is most likely?

Accepted Answer

A) hemophilia A 
B) hemophilia B 
C) VWD, type 1 
D) factor X deficiency 
A) hemophilia A 
B) hemophilia B 
C) VWD, type 1 
D) factor X deficiency

Question 4

Which of the following is decreased in DIC?

Accepted Answer

A) fibrinogen 
B) PT 
C) PTT 
D) fibrin degradation products 
A) fibrinogen 
B) PT 
C) PTT 
D) fibrin degradation products

Question 5

Two children in the same family have recurrent, chronic bruising in multiple sites, repeated long-lasting epistaxis, and minor bleeding after dental work. Which type of disorder is most likely?
-Which of the following would be appropriate initial testing for the siblings in Question above?

Accepted Answer

A) fibrinogen, D-dimer, and platelet aggregation studies 
B) factor VIII assay, liver function tests, and vitamin K level 
C) von Willebrand factor (VWF) antigen, Bethesda titer, and reptilase time 
D) prothrombin time (PT), partial thromboplastin time (PTT), and platelet count 
A) fibrinogen, D-dimer, and platelet aggregation studies 
B) factor VIII assay, liver function tests, and vitamin K level 
C) von Willebrand factor (VWF) antigen, Bethesda titer, and reptilase time 
D) prothrombin time (PT), partial thromboplastin time (PTT), and platelet count

Question 6

Which of the following screening tests would be normal when the plasma for the patient in Question 26 is analyzed?

Accepted Answer

A) PT 
B) PTT 
C) TT 
D) all of the above 
A) PT 
B) PTT 
C) TT 
D) all of the above

Question 7

A 39-year-old male patient shows evidence of poor wound healing and a history of joint bleeding.What protein deficiency is most likely present?

Accepted Answer

A) factor VIII 
B) factor IX 
C) factor V 
D) factor XIII 
A) factor VIII 
B) factor IX 
C) factor V 
D) factor XIII

Exam 38: Hemorrhagic Disorders and Laboratory Assessment

The urea solubility test is used to detect deficiencies in which factor?

Clot-based mixing studies and Bethesda titers are used to test for

Which of the following is decreased in DIC?

Two children in the same family have recurrent, chronic bruising in multiple sites, repeated long-lasting epistaxis, and minor bleeding after dental work. Which type of disorder is most likely? -Which of the following would be appropriate initial testing for the siblings in Question above?

Which of the following screening tests would be normal when the plasma for the patient in Question 26 is analyzed?

A 39-year-old male patient shows evidence of poor wound healing and a history of joint bleeding.What protein deficiency is most likely present?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Bone Marrow Examination

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

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