Question 1

What is the most common site for bone marrow aspiration in an adult?

Accepted Answer

A) sternum 
B) posterior iliac crest 
C) tibia 
D) ribs 
A) sternum 
B) posterior iliac crest 
C) tibia 
D) ribs B

Question 2

What bone marrow sample is best to determine fat-to-cell ratio and overall cellularity,as well as for searching for malignant cells?

Accepted Answer

A) core biopsy 
B) aspirate smears 
C) peripheral blood 
D) Prussian blue stain 
A) core biopsy 
B) aspirate smears 
C) peripheral blood 
D) Prussian blue stain A

Question 3

Which of the following is least helpful in evaluating bone marrow findings?

Accepted Answer

A) differential performed on the aspirate 
B) clinical findings 
C) laboratory data from chemistry, immunology, and microbiology 
D) examination of peripheral blood 
A) differential performed on the aspirate 
B) clinical findings 
C) laboratory data from chemistry, immunology, and microbiology 
D) examination of peripheral blood C

Question 4

The best use for bone marrow aspirate smears is

Accepted Answer

A) counting the differential. 
B) determining overall cellularity. 
C) estimating fat-to-cell ratio. 
D) evaluating for focal lesions such as lymphoma. 
A) counting the differential. 
B) determining overall cellularity. 
C) estimating fat-to-cell ratio. 
D) evaluating for focal lesions such as lymphoma.

Question 5

The myeloid-to-erythroid (M:E)ratio of a bone marrow in a 35-year-old male is 1:1.Select the correct interpretation.

Accepted Answer

A) normal 
B) abnormal, more fat cells than normal 
C) abnormal, more white cell precursors than normal 
D) abnormal, more red cell precursors than normal 
A) normal 
B) abnormal, more fat cells than normal 
C) abnormal, more white cell precursors than normal 
D) abnormal, more red cell precursors than normal

Question 6

A bone marrow aspirate shows copious blue granules with the Prussian blue stain.Select the correct interpretation.

Accepted Answer

A) iron overload 
B) iron deficiency 
C) tumor cells present 
D) megakaryocytes increased 
A) iron overload 
B) iron deficiency 
C) tumor cells present 
D) megakaryocytes increased

Question 7

Low power (×10)is used to count and evaluate which of the following?

Accepted Answer

A) immature neutrophils 
B) megakaryocytes 
C) nucleated red cells 
D) plasma cells 
A) immature neutrophils 
B) megakaryocytes 
C) nucleated red cells 
D) plasma cells

Question 8

Which of the following cell types tend to be found in molded clusters in the bone marrow?

Accepted Answer

A) megakaryocytes 
B) malignant cells 
C) immature granulocytes 
D) monocytes 
A) megakaryocytes 
B) malignant cells 
C) immature granulocytes 
D) monocytes

Question 9

The sites of active red marrow differ for adults and young children.Which one site is active in children but not in adults?

Accepted Answer

A) proximal end of the long bones 
B) skull 
C) distal ends of the long bones 
D) pelvis 
A) proximal end of the long bones 
B) skull 
C) distal ends of the long bones 
D) pelvis

Question 10

A cell is described as having an eccentric,heavily stained (condensed chromatin)nucleus with blue cytoplasm.A pale perinuclear Golgi complex is noted next to the nucleus.What is this cell?

Accepted Answer

A) myelocyte 
B) plasma cell 
C) lymphocyte 
D) myeloblast 
A) myelocyte 
B) plasma cell 
C) lymphocyte 
D) myeloblast

Question 11

Osteoblasts can be easily confused with

Accepted Answer

A) megakaryocytes. 
B) osteoclasts. 
C) plasma cells. 
D) macrophages. 
A) megakaryocytes. 
B) osteoclasts. 
C) plasma cells. 
D) macrophages.

Question 12

For which of the following is obtaining a bone marrow core biopsy mandatory?

Accepted Answer

A) Anemia is suspected. 
B) Leukemia is suspected. 
C) Megakaryocyte disorders are suspected. 
D) Aspirate is a dry tap. 
A) Anemia is suspected. 
B) Leukemia is suspected. 
C) Megakaryocyte disorders are suspected. 
D) Aspirate is a dry tap.

Question 13

What type of preparation is preferred for bone marrow aspirates?

Accepted Answer

A) coverslip smears from a bone marrow fragment called a spicule 
B) wedge smears made from the blood surrounding marrow fragments 
C) touch preps from rolling the biopsy on a glass slide 
D) smears of the biopsy made with an automated slide maker 
A) coverslip smears from a bone marrow fragment called a spicule 
B) wedge smears made from the blood surrounding marrow fragments 
C) touch preps from rolling the biopsy on a glass slide 
D) smears of the biopsy made with an automated slide maker

Question 14

What stain is most commonly used for bone marrow aspirates?

Accepted Answer

A) Prussian blue 
B) new methylene blue 
C) hematoxylin and eosin (H&
E)  
D) Wright 
A) Prussian blue 
B) new methylene blue 
C) hematoxylin and eosin (H&
E)  
D) Wright

Question 15

Which of the following would be a valid indication for performing a bone marrow aspiration?

Accepted Answer

A) iron deficiency 
B) folate deficiency 
C) unexpected pancytopenia 
D) leukocytosis from a severe infection 
A) iron deficiency 
B) folate deficiency 
C) unexpected pancytopenia 
D) leukocytosis from a severe infection

Exam 17: Bone Marrow Examination

What is the most common site for bone marrow aspiration in an adult?

What bone marrow sample is best to determine fat-to-cell ratio and overall cellularity,as well as for searching for malignant cells?

Which of the following is least helpful in evaluating bone marrow findings?

The best use for bone marrow aspirate smears is

The myeloid-to-erythroid (M:E)ratio of a bone marrow in a 35-year-old male is 1:1.Select the correct interpretation.

A bone marrow aspirate shows copious blue granules with the Prussian blue stain.Select the correct interpretation.

Low power (×10)is used to count and evaluate which of the following?

Which of the following cell types tend to be found in molded clusters in the bone marrow?

The sites of active red marrow differ for adults and young children.Which one site is active in children but not in adults?

A cell is described as having an eccentric,heavily stained (condensed chromatin)nucleus with blue cytoplasm.A pale perinuclear Golgi complex is noted next to the nucleus.What is this cell?

Osteoblasts can be easily confused with

For which of the following is obtaining a bone marrow core biopsy mandatory?

What type of preparation is preferred for bone marrow aspirates?

What stain is most commonly used for bone marrow aspirates?

Which of the following would be a valid indication for performing a bone marrow aspiration?

An Overview of Clinical Laboratory Hematology

Safety in the Hematology Laboratory

Blood Specimen Collection

Care and Use of the Microscope

Quality Assurance in Hematology and Hemostasis Testing

Cellular Structure and Function

Hematopoiesis

Erythrocyte Production and Destruction

Erythrocyte Metabolism and Membrane Structure and Function

Hemoglobin Metabolism

Iron Kinetics and Laboratory Assessment

Leukocyte Development, Kinetics, and Functions

Platelet Production, Structure, and Function

Manual, Semiautomated and Point-of-Care Testing in Hematology

Automated Blood Cell Analysis

Examination of the Peripheral Blood Film and Correlation with the Complete Blood Count

Body Fluid Analysis in the Hematology Laboratory

Anemias: Red Blood Cell Morphology and Approach to Diagnosis

Disorders of Iron Kinetics and Heme Metabolism

Anemias Caused by Defects of DNA Metabolism

Bone Marrow Failure

Introduction to Increased Destruction of Erythrocytes

Intrinsic Defects Leading to Increased Erythrocyte Destruction

Extrinsic Defects Leading to Increased Erythrocyte Destruction Nonimmune Causes

Extrinsic Defects Leading to Increased Erythrocyte Destruction Immune Causes

Hemoglobinopathies (Structural Defects in Hemoglobin)

Thalassemias

Nonmalignant Leukocyte Disorders

Cytogenetics

Molecular Diagnostics in Hematopathology

Flow Cytometric Analysis in Hematologic Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Mature Lymphoid Neoplasms

Normal Hemostasis and Coagulation

Hemorrhagic Disorders and Laboratory Assessment

Thrombotic Disorders and Laboratory Assessment

Thrombocytopenia and Thrombocytosis

Qualitative Disorders of Platelets and Vasculature

Laboratory Evaluation of Hemostasis

Antithrombotic Therapies and their Laboratory Assessment

Hemostasis and Coagulation Instrumentation

Pediatric and Geriatric Hematology and Hemostasis

Filters