Exam 30: Molecular Immunology

The ________and _________ domains of the class II MHC protein interact to form a peptide- binding site.

Some activated B cells are transformed into________ cells that secrete antibodies, and others remain as ________cells.

Some immature B cells are reactive to self- antigens but do not become activated even when exposed to high concentrations of self- antigens.

Antibodies consist of four polypeptides,________ heavy chains, and ________light chains.

Assuming that each heavy and light chain has an equal chance to be expressed in each cell, approximately how many possible antibodies can be expressed?

If you were a surgeon about to do an organ transplant, what measures would you take to ensure that the recipient's body does not reject the donor organ?

Selection against self- reactive clones results in the development of tolerance.

Somatic hypermutation mechanisms generate TCR diversity.

In antigen binding, MHC protein binds to the T cell epitope, whereas the TCR binds the MHC motif.

The major histocompatibility complex is also called the________ .

TLR- 4 consists of ________distinct protein domains.

Which of the following roles do B cells play?

TCRs associate with the adapter molecule

The peptides bound by a single MHC protein share a common________ .

The main bonds present in the C domain of antigen- binding proteins are

Briefly describe positive selection in T cell maturation.

When two allelic variants are expressed equally, they are said to be________.

The invariant amino acids in each peptide motif bound MHC proteins are _________.

Mannose on mammalian cells is inaccessible to mannose- binding lectin.

The antigen- binding site of an antibody accommodates a small portion of the antigen called a(n) _________ .