Exam 30: Molecular Immunology

B cells react with antigens through TCR antigen receptors.

Immunoglobulins and TCRs associate with adaptor molecules that have________ , because they possess tyrosines that can be phophorylated.

The human leukocyte antigen spans about 4Mbp on human chromosome 6.

The clonal selection theory states that each antigen- reactive B cell or T cell has a cell surface receptor for a single antigen epitope.

Adapter molecules associate covalently with their respective antigen receptors in the membrane.

T cells undergo immune selection against potential antigen- reactive cells and selection for those cells that react strongly with self- antigens.

The complete second signal for B cell activation requires which of the following interactions?

Clonal anergy is a state of

All proinflammatory cytokines except________ induce fever at the systemic level.

All TLR can react with only one specific PAMP.

Briefly describe the affinity maturation process.

PRRs are found on which of the following cells?

Class I MHC proteins have groves with open ends.

Cytokines produced by lymphocytes are often called _________ or _________.

Antigen receptors can directly connect to signal transduction pathways because immunoglobulins and TCRs have very small cytoplasmic domains.

Design five amino acid peptides bound by a single hypothetical class I protein. The peptide should be 10 amino acids long and have two anchor residues at position 2 and 5 on the motif.

What are the differences and similarities between Class I and Class II MHC proteins?

An epitope is ________amino acids long.

Which of the following is/are MHC class I genes?

The occurrence of multiple alleles at a specific locus is called _________ .