Exam 19: Epigenetic Regulation in Eukaryotes

About 5% of those with Rubinstein- Taybi syndrome develops cancer as a result to decreased gene expression.This is directly linked to abnormal histone modification caused by a dysfunctional enzyme.What enzyme is this?

Even though cancer genomes are overall hypomethylated,explain why some genes are hypermethylated in cancer cells.

Which of the following is an example of genomic imprinting in humans?

Describe the four types of long noncoding RNAs lncRNA).

A particular small noncoding RNA that is linked to spermatogenesis is most likely classified as what kind of noncoding RNA?

In terms of epigenetics,how the promoter would be described for a gene that is not expressed in lung tissue but is expressed in heart tissue?

Based on rat studies that show how maternal nurturing helps offspring respond better to stress propose a model to help explain why human children who are abused have a higher suicide rate.

All of the following are epigenetic mechanisms,EXCEPT ________ .

The data from the NIH Roadmap Epigenomics Project are classified into which five categories?

Which DNA methyltransferase DNMT)is important in maintaining DNA methylation patterns during DNA replication?

Which of the following statements is most true regarding X- inactivation?

Prader- Willi PW)and Angelman syndromes AS)are imprinting disorders of the same region on chromosome 15.Normally,the genes associated with PW are________ imprinted silenced ,and the one gene associated with AS is________ imprinted silenced .

Long noncoding RNAs that partially overlap protein- coding genes and are transcribed in the opposite direction are best classified as________ .

Compare and contrast DNMT1,DNMT3a,and DNMT3b in regards to what they do,when they act,and how they affect gene transcription.

Which of the following statements is the most accurate in regards to mice pups who receive less maternal nurturing?

What are the two goals of the NIH Roadmap Epigenomics Project?

Different modification of the histone have different effects on gene expression.For instance,the ninth amino acid of histone 3 is a lysine H3K9)can be acetylated once or methylated up to three times.Which of the following is true regarding H3K9 modification?

Is there a risk for epigenetic linked diseases in using artificial reproductive technologies ART)such as in vitro fertilization?

In humans,the number of genes that are imprinted is less than 1%.These imprinted genes are usually associated with________ .

Explain how HATs and HDACs can lead to the formation of cancer.