Exam 12: Antimicrobial Agent Mechanisms of Action and Resistance Mechanisms

This type of pathogen may demonstrate decreases or loss of porin synthesis in combination with other resistance mechanisms, resulting in multidrug-resistant pathogens.

In gram-positive bacteria, this is substantially thicker and more multilayered than in gram-negative bacteria.

The members of the polyketide class of antibiotics include all the following, except

Plasmids are

Streptococcus pneumoniae and Streptococcus pyogenes use efflux as an effective mechanism for acquired resistance to

Acquired mechanisms of resistance are those that

Relatively nontoxic antimicrobial therapeutic agents include all of the following, except

Which antibiotic inhibits folate synthesis, providing the essential precursor molecule, pyridine thymidylate, needed in DNA synthesis?

This antibiotic interferes with DNA transcription by blocking of RNA chain elongation.

Acquired antibiotic resistance mechanisms include

What is a porin?

The outer membrane of gram-negative bacteria is composed of

Biofilms are groups of bacteria that are irreversibly attached to surfaces and are embedded in a matrix of extracellular polymeric substances. They are most commonly found on

These antibiotics are cationic carbohydrate-containing molecules, and their positive charge provides the basis for their interaction with the 30S ribosomal subunit. What class of antibiotic are these?

Penicillins, cephalosporins, monobactams, and carbapenems all have this ring in their structure that is responsible for inhibiting the transpeptidation reaction, resulting in bacterial lysis and cell death.

The members of the macrolide class of antibiotics include all the following, except

These two classes of antibiotics allow initiation and mRNA translation to begin, but they act by inhibiting peptide elongation.

All of the following antibiotics target the 50S ribosomal subunit to prevent mRNA translation in the bacteria, except

Mechanisms that mediate intrinsic antibiotic resistance include all the following, except

Intrinsic mechanisms of resistance are