Question 1

Which one of the following drugs is NOT used in the management of multiple sclerosis to modify the immune response?

Accepted Answer

A)  Baclofen 
B)  Glatiramer 
C)  Prednisone 
D)  Interferon $\beta$ 
A)  Baclofen 
B)  Glatiramer 
C)  Prednisone 
D)  Interferon $\beta$ A

Question 2

Mr Penson was being treated with drugs for Parkinson's disease and noted an increase in his libido.What drug may have caused this?

Accepted Answer

A)  The dopamine precursor, levodopa 
B)  The antimuscarinic, benzhexol 
C)  Amantadine 
D)  The MAO-B inhibitor, selegiline 
A)  The dopamine precursor, levodopa 
B)  The antimuscarinic, benzhexol 
C)  Amantadine 
D)  The MAO-B inhibitor, selegiline A

Question 3

Parkinson's disease is a defect in the function of which transmitter system in the basal ganglia?

Accepted Answer

A)  Noradrenaline 
B)  Acetylcholine 
C)  Dopamine 
D)  Serotonin 
A)  Noradrenaline 
B)  Acetylcholine 
C)  Dopamine 
D)  Serotonin C

Question 4

What is the rationale for giving levodopa and carbidopa as combination therapy for Parkinson's disease?

Accepted Answer

A)  Levodopa increases the therapeutic effect of carbidopa. 
B)  Carbidopa inhibits the breakdown of levodopa, increasing distribution to the central nervous system. 
C)  Both preparations are required to increase the availability of dopamine in the peripheries. 
D)  Levodopa increases the half-life of carbidopa. 
A)  Levodopa increases the therapeutic effect of carbidopa. 
B)  Carbidopa inhibits the breakdown of levodopa, increasing distribution to the central nervous system. 
C)  Both preparations are required to increase the availability of dopamine in the peripheries. 
D)  Levodopa increases the half-life of carbidopa.

Question 5

How does donepezil work to improve the symptoms associated with Alzheimer's disease?

Accepted Answer

A)  It induces sedation that reduces agitation in sufferers and allows recovery time for the brain, which in turn improves memory. 
B)  It stimulates the release of the neurotransmitter acetylcholine into synapses. 
C)  It blocks the release of the neurotransmitter dopamine to improve the balance between dopamine and acetylcholine. 
D)  It blocks the enzyme that degrades acetylcholine, which increases the availability and prolongs the action of the neurotransmitter. 
A)  It induces sedation that reduces agitation in sufferers and allows recovery time for the brain, which in turn improves memory. 
B)  It stimulates the release of the neurotransmitter acetylcholine into synapses. 
C)  It blocks the release of the neurotransmitter dopamine to improve the balance between dopamine and acetylcholine. 
D)  It blocks the enzyme that degrades acetylcholine, which increases the availability and prolongs the action of the neurotransmitter.

Question 6

To ensure a uniform concentration of levodopa,the dose should be taken:

Accepted Answer

A)  with milk. 
B)  before exercise. 
C)  immediately before breakfast and one hour after the evening meal. 
D)  at the same time each day and in a consistent manner in relation to food. 
A)  with milk. 
B)  before exercise. 
C)  immediately before breakfast and one hour after the evening meal. 
D)  at the same time each day and in a consistent manner in relation to food.

Question 7

Excessive glutamine repeats in the protein coded by the HTT gene is associated with:

Accepted Answer

A)  motor neurone disease. 
B)  multiple sclerosis. 
C)  Huntington's disease. 
D)  Alzheimer's disease. 
A)  motor neurone disease. 
B)  multiple sclerosis. 
C)  Huntington's disease. 
D)  Alzheimer's disease.

Question 8

Neuroleptic drug-induced Parkinsonian symptoms are often treated with:

Accepted Answer

A)  an antimuscarinic agent. 
B)  a serotonin receptor agonist. 
C)  an antiemetic agent. 
D)  an increase in neuroleptic dose. 
A)  an antimuscarinic agent. 
B)  a serotonin receptor agonist. 
C)  an antiemetic agent. 
D)  an increase in neuroleptic dose.

Question 9

Alzheimer's disease is characterised by the lack of which neurotransmitter in the higher centres of the brain?

Accepted Answer

A)  Noradrenaline 
B)  Acetylcholine 
C)  Dopamine 
D)  Serotonin 
A)  Noradrenaline 
B)  Acetylcholine 
C)  Dopamine 
D)  Serotonin

Question 10

Which of the following is not an appropriate clinical management activity in relation to tetrabenazine therapy for Huntington's disease?

Accepted Answer

A)  The client should avoid drinking alcohol with tetrabenazine. 
B)  Therapy is stopped if dysphagia or choking occurs. 
C)  If depression occurs, the dose of tetrabenazine is reduced or treatment is stopped. 
D)  The dose of tetrabenazine is reduced gradually over two days to prevent rebound involuntary movements. 
A)  The client should avoid drinking alcohol with tetrabenazine. 
B)  Therapy is stopped if dysphagia or choking occurs. 
C)  If depression occurs, the dose of tetrabenazine is reduced or treatment is stopped. 
D)  The dose of tetrabenazine is reduced gradually over two days to prevent rebound involuntary movements.

Exam 36: Medicines Used in Neurodegenerative Disorders

Which one of the following drugs is NOT used in the management of multiple sclerosis to modify the immune response?

Mr Penson was being treated with drugs for Parkinson's disease and noted an increase in his libido.What drug may have caused this?

Parkinson's disease is a defect in the function of which transmitter system in the basal ganglia?

What is the rationale for giving levodopa and carbidopa as combination therapy for Parkinson's disease?

How does donepezil work to improve the symptoms associated with Alzheimer's disease?

To ensure a uniform concentration of levodopa,the dose should be taken:

Excessive glutamine repeats in the protein coded by the HTT gene is associated with:

Neuroleptic drug-induced Parkinsonian symptoms are often treated with:

Alzheimer's disease is characterised by the lack of which neurotransmitter in the higher centres of the brain?

Which of the following is not an appropriate clinical management activity in relation to tetrabenazine therapy for Huntington's disease?

Sociocultural Aspects

Health Professionals and the Law

Ethical Issues

the Roles and Responsibilities of Health Professionals in Medicine Adherence, Education and Advocacy

the Roles and Responsibilities of Health Professionals in Medicine Management

Medicine Formulations, Storage and Routes of Administration

the Clinical Decision-making Process

Medicine Administration Strategies and Documentation

Medication Errors

Management of Common Adverse Drug Reactions

Risk Communication: Balancing the Benefits and Risks of Drug Treatment

Drug Nomenclature

Pharmacokinetics: Absorption and Distribution

Pharmacokinetics Metabolism and Excretion

Drug Interactions

Pharmacodynamics

Drug Development, Evaluation and Safety

Genetic Considerations in Pharmacology

Pharmacokinetic Factors That Modify Drug Action

Paediatric and Geriatric Pharmacology

Poisoning and Envenomation

the Management of Acute Clinical Overdose

Contemporary Drugs of Abuse

Drug Abuse in Sport

General Aspects of Neuropharmacology

Adrenergic Pharmacology

Cholinergic Pharmacology

An Introduction to Chemical Mediators

Histamine and Antihistamines

Prostaglandins and Serotonin

Nitric Oxide and the Endothelins

General concepts of Psychopharmacology

Antipsychotics

Anxiolytics and Hypnotics

Antidepressants and Mood Stabilisers

Antiseizure Agents and Muscle Relaxants

Central Nervous System Stimulants

Opioid Analgesics

Anti-inflammatory, Antipyretic and Non-opioid Analgesic Agents

Medicines Used to Treat Migraine

General Anaesthesia

Local Anesthesia

Medicines Used to Lower Blood Lipids

Antihypertensive Agents

Medicines Used to Promote Tissue Perfusion

Antithrombotic, Fibrinolytic and Haemostatic Agents

Diuretics and Other Renal Medicines

Topic: Medicines Used to Treat Heart Failure

Medicines Used to Treat Cardiac Dysrhythmia

Fluid and Potassium Imbalances

Antianaemic Agents

Medicines Used to Maintain Gas Exchange

Medicines for Upper Respiratory Tract Conditions

Upper Gastrointestinal Tract Medicines

Lower Castrointestinal Tract Medicines

Antiemetic Agents

Enteral and Parenteral Nutrition

Medicines and the Pituitary Gland

Medicines and the Thyroid

Medicines and the Pancreas

Medicines Affecting the Adrenal Cortex

Medicines and the Gonads

Medicines and Bone Metabolism

Hyperuricaemia and Gout

Obesity and Its Treatment

Introduction to Chemotherapy

Sulfonamides and Trimethoprim

Antibacterial Agents

Antituberculotic and Antileprotic Agents