Question 1

Which of the following statements is true regarding aspirin and the clotting mechanism?

Accepted Answer

A) Aspirin reversibly interferes with the clotting mechanism by reducing platelet adhesiveness. 
B) Replacement of all of the affected platelets is required to produce normal clotting. 
C) With lower doses of aspirin,1 1/2 days should elapse to obtain normal clotting. 
D) Aspirin stimulates production of prothrombin. 
A) Aspirin reversibly interferes with the clotting mechanism by reducing platelet adhesiveness. 
B) Replacement of all of the affected platelets is required to produce normal clotting. 
C) With lower doses of aspirin,1 1/2 days should elapse to obtain normal clotting. 
D) Aspirin stimulates production of prothrombin.

Question 2

Which of the following is the most common side effect from aspirin?

Accepted Answer

A) Gastrointestinal effects 
B) Bleeding 
C) Hepatic and renal effects 
D) Hypersensitivity 
A) Gastrointestinal effects 
B) Bleeding 
C) Hepatic and renal effects 
D) Hypersensitivity

Question 3

The pain threshold varies greatly in individuals because of different perceptions of pain.

Accepted Answer

A) Both parts of the statements are true. 
B) Both parts of the statements are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true. 
A) Both parts of the statements are true. 
B) Both parts of the statements are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true.

Question 4

Raising the pain threshold increases one's reaction to pain.

Accepted Answer

A) True 
 B)False

Question 5

Salicylates' mechanism of action involves inhibiting prostaglandin synthesis.

Accepted Answer

A) True 
 B)False

Question 6

Rheumatoid arthritis (RA)is most likely to involve which part of the body?

Accepted Answer

A) Liver 
B) Brain 
C) Bones 
D) Kidneys 
A) Liver 
B) Brain 
C) Bones 
D) Kidneys

Question 7

Which of the following choices has antiinflammatory,antipyretic,analgesic,and antiplatelet action?

Accepted Answer

A) Acetaminophen 
B) Codeine 
C) Aspirin 
D) Hydrocodone 
A) Acetaminophen 
B) Codeine 
C) Aspirin 
D) Hydrocodone

Question 8

The incidence of true aspirin allergy is

Accepted Answer

A) approximately 10%. 
B) between 2% and 5%. 
C) less than 1%. 
D) unknown;it has not ever been recorded. 
A) approximately 10%. 
B) between 2% and 5%. 
C) less than 1%. 
D) unknown;it has not ever been recorded.

Question 9

Which of the following is true regarding these pharmacologic effects of therapeutic doses of acetaminophen? (1)No effect on the cardiovascular system.(2)Does not produce gastric bleeding.(3)Does not affect platelet adhesiveness.(4)Does not affect uric acid excretion.

Accepted Answer

A) 1,2,3,4 
B) 1,2,3 
C) 2,3,4 
D) 1 only 
A) 1,2,3,4 
B) 1,2,3 
C) 2,3,4 
D) 1 only

Question 10

Low-dose aspirin therapy is recommended for which of the following? (Select all that apply. )

Accepted Answer

A) People who have had heart bypass surgery 
B) Men aged 45 to 79 with no history of heart disease 
C) Women aged 55 to 79 with no history of heart disease 
D) A person with gastroesophageal reflux disease (GER
D)  
A) People who have had heart bypass surgery 
B) Men aged 45 to 79 with no history of heart disease 
C) Women aged 55 to 79 with no history of heart disease 
D) A person with gastroesophageal reflux disease (GER
D)

Question 11

NSAIDs carry "black box warnings" for which of the following types of events? (Select all that apply. )

Accepted Answer

A) Respiratory 
B) Gastrointestinal 
C) Cardiovascular 
D) Endocrine 
A) Respiratory 
B) Gastrointestinal 
C) Cardiovascular 
D) Endocrine

Question 12

What is the usual adult dosage of aspirin for the treatment of pain or fever?

Accepted Answer

A) 250 mg every 4 hours 
B) 3 to 6 g per day 
C) 650 mg every 4 hours 
D) 800 mg every 4 hours 
E) 160 mg per day 
A) 250 mg every 4 hours 
B) 3 to 6 g per day 
C) 650 mg every 4 hours 
D) 800 mg every 4 hours 
E) 160 mg per day

Question 13

A drug interaction between aspirin and _____ can result in significant bleeding.

Accepted Answer

A) probenecid 
B) warfarin 
C) methotrexate 
D) sulfonylureas 
A) probenecid 
B) warfarin 
C) methotrexate 
D) sulfonylureas

Question 14

Which of the following statements is true concerning the pharmacokinetics of aspirin?

Accepted Answer

A) Plain,unbuffered aspirin produces its peak effect on an empty stomach in 15 minutes. 
B) Buffered aspirin has a slower peak of aspirin than plain aspirin. 
C) The half-life of unhydrolyzed aspirin is approximately 90 minutes. 
D) Aspirin exhibits zero-order kinetics. 
A) Plain,unbuffered aspirin produces its peak effect on an empty stomach in 15 minutes. 
B) Buffered aspirin has a slower peak of aspirin than plain aspirin. 
C) The half-life of unhydrolyzed aspirin is approximately 90 minutes. 
D) Aspirin exhibits zero-order kinetics.

Question 15

Dental pain following a simple tooth extraction is best managed with which of the following choices?

Accepted Answer

A) Codeine 60 mg 
B) Ibuprofen 400 mg 
C) Acetaminophen 650 mg 
D) Aspirin 650 mg 
E) Placebo 
A) Codeine 60 mg 
B) Ibuprofen 400 mg 
C) Acetaminophen 650 mg 
D) Aspirin 650 mg 
E) Placebo

Question 16

Febuxostat (Uloric)is used to treat

Accepted Answer

A) fever in a young child. 
B) dental pain when an NSAID is indicated. 
C) certain kinds of cancer and autoimmune diseases. 
D) gout. 
A) fever in a young child. 
B) dental pain when an NSAID is indicated. 
C) certain kinds of cancer and autoimmune diseases. 
D) gout.

Question 17

Which of the following choices is currently the most popular COX II-specific agent on the market?

Accepted Answer

A) Celecoxib 
B) Rofecoxib 
C) Valdecoxib 
D) Indomethacin 
A) Celecoxib 
B) Rofecoxib 
C) Valdecoxib 
D) Indomethacin

Question 18

Each of the following is an indication for the use of NSAIDs except one.Which is the exception?

Accepted Answer

A) Dysmenorrhea 
B) Gouty arthritis 
C) Known aspirin hypersensitivity 
D) Asthma 
A) Dysmenorrhea 
B) Gouty arthritis 
C) Known aspirin hypersensitivity 
D) Asthma

Question 19

Oral administration with _____ is indicated only as continuation to intravenous (IV)or intramuscular (IM)therapy.

Accepted Answer

A) fenoprofen 
B) ketorolac 
C) naproxen sodium 
D) diflunisal 
A) fenoprofen 
B) ketorolac 
C) naproxen sodium 
D) diflunisal

Question 20

Salicylism is a toxic effect from acetaminophen.

Accepted Answer

A) True 
 B)False

Exam 5: Nonopioid Non-Narcoticanalgesics

Which of the following statements is true regarding aspirin and the clotting mechanism?

Which of the following is the most common side effect from aspirin?

The pain threshold varies greatly in individuals because of different perceptions of pain.

Raising the pain threshold increases one's reaction to pain.

Salicylates' mechanism of action involves inhibiting prostaglandin synthesis.

Rheumatoid arthritis (RA)is most likely to involve which part of the body?

Which of the following choices has antiinflammatory,antipyretic,analgesic,and antiplatelet action?

The incidence of true aspirin allergy is

Which of the following is true regarding these pharmacologic effects of therapeutic doses of acetaminophen? (1)No effect on the cardiovascular system.(2)Does not produce gastric bleeding.(3)Does not affect platelet adhesiveness.(4)Does not affect uric acid excretion.

Low-dose aspirin therapy is recommended for which of the following? (Select all that apply. )

NSAIDs carry "black box warnings" for which of the following types of events? (Select all that apply. )

What is the usual adult dosage of aspirin for the treatment of pain or fever?

A drug interaction between aspirin and _____ can result in significant bleeding.

Which of the following statements is true concerning the pharmacokinetics of aspirin?

Dental pain following a simple tooth extraction is best managed with which of the following choices?

Febuxostat (Uloric)is used to treat

Which of the following choices is currently the most popular COX II-specific agent on the market?

Each of the following is an indication for the use of NSAIDs except one.Which is the exception?

Oral administration with _____ is indicated only as continuation to intravenous (IV)or intramuscular (IM)therapy.

Salicylism is a toxic effect from acetaminophen.

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