Question 1

Slowly growing cells are more susceptible to inhibition or destruction by antineoplastic agents.

Accepted Answer

A) True 
 B)False  False

Question 2

Which of the following is a treatment option to alleviate symptoms of mucositis?

Accepted Answer

A) Injection of corticosteroids 
B) Oral rinse of 2% viscous lidocaine 
C) A 1-week course of oral antibiotics 
D) Use of a chlorhexidine rinse 
A) Injection of corticosteroids 
B) Oral rinse of 2% viscous lidocaine 
C) A 1-week course of oral antibiotics 
D) Use of a chlorhexidine rinse B

Question 3

Dental procedures should be performed for a patient taking bisphosphonates

Accepted Answer

A) during bisphosphonate-free holidays. 
B) before starting bisphosphonate therapy or within 3 months of beginning therapy. 
C) only when the course bisphosphonate therapy has been completed. 
D) at any time deemed necessary. 
A) during bisphosphonate-free holidays. 
B) before starting bisphosphonate therapy or within 3 months of beginning therapy. 
C) only when the course bisphosphonate therapy has been completed. 
D) at any time deemed necessary. B

Question 4

Antineoplastic agents may be used in the management of diseases with an inflammatory component.

Accepted Answer

A) True 
 B)False

Question 5

Bisphosphonate-free holidays are not recommended before a dental procedure because these drugs stay in the bone for years.

Accepted Answer

A) True 
 B)False

Question 6

Antineoplastic agents will affect bone marrow,leading to

Accepted Answer

A) leukopenia and thrombocytopenia. 
B) leukocytosis and thrombocytopenia. 
C) leukopenia and polycythemia. 
D) leukocytosis and polycythemia. 
A) leukopenia and thrombocytopenia. 
B) leukocytosis and thrombocytopenia. 
C) leukopenia and polycythemia. 
D) leukocytosis and polycythemia.

Question 7

Neurologic adverse effects are prevalent in all of the following antineoplastic agents except which one?

Accepted Answer

A) Asparaginase (Elspar) 
B) Methotrexate (Amethopterin) 
C) Vincristine (Oncovin) 
D) Procarbazine (Matulane) 
A) Asparaginase (Elspar) 
B) Methotrexate (Amethopterin) 
C) Vincristine (Oncovin) 
D) Procarbazine (Matulane)

Question 8

Each of the following will have the action prolonged and toxicity increased by allopurinol,which is used to prevent hyperuricemia,except one.Which is the exception?

Accepted Answer

A) 5-Fluorouracil 
B) Azathioprine 
C) Cyclophosphamide 
D) Mercaptopurine 
A) 5-Fluorouracil 
B) Azathioprine 
C) Cyclophosphamide 
D) Mercaptopurine

Question 9

Nausea and vomiting caused by antineoplastic agent therapy can be managed by administration of

Accepted Answer

A) procarbazine. 
B) codeine. 
C) omeprazole. 
D) prochlorperazine. 
E) cisplatin. 
A) procarbazine. 
B) codeine. 
C) omeprazole. 
D) prochlorperazine. 
E) cisplatin.

Question 10

Which folic acid analog antimetabolite antineoplastic drug is also used to treat rheumatoid arthritis?

Accepted Answer

A) Bleomycin (Blenoxane) 
B) Methotrexate (Amethopterin,MTX) 
C) Interferon alpha-n3 (Alferon N) 
D) Vincristine (Oncovin) 
E) Fluorouracil (5-FU) 
A) Bleomycin (Blenoxane) 
B) Methotrexate (Amethopterin,MTX) 
C) Interferon alpha-n3 (Alferon N) 
D) Vincristine (Oncovin) 
E) Fluorouracil (5-FU)

Question 11

_____ effects are associated primarily with administration or vincristine (Oncovin)or vinblastine (Velban).

Accepted Answer

A) Gastrointestinal 
B) Dermatologic 
C) Neurologic 
D) Immunosuppressant 
A) Gastrointestinal 
B) Dermatologic 
C) Neurologic 
D) Immunosuppressant

Question 12

Which of the following are symptoms of adverse reactions caused by bone marrow suppression: (1)susceptibility to infection, (2)bleeding, (3)high blood pressure, (4)fatigue?

Accepted Answer

A) 1,2,3,4 
B) 1,2,4 
C) 1,3,4 
D) 1,2 
E) 3,4 
A) 1,2,3,4 
B) 1,2,4 
C) 1,3,4 
D) 1,2 
E) 3,4

Question 13

The appointment should be scheduled _____ chemotherapy when providing oral care for patients on antineoplastic agents.

Accepted Answer

A) just before starting 
B) after the first few days of 
C) during the course of 
D) only after 
A) just before starting 
B) after the first few days of 
C) during the course of 
D) only after

Question 14

Antimetabolites such as methotrexate attack the cells at the S phase of the cell cycle because they interfere with purine and pyrimidine biosynthesis.

Accepted Answer

A) Both statements are true. 
B) Both statements are false. 
C) The first statement is true,the second is false. 
D) The first statement is false,the second is true. 
A) Both statements are true. 
B) Both statements are false. 
C) The first statement is true,the second is false. 
D) The first statement is false,the second is true.

Question 15

An example of a cell-cycle nonspecific antineoplastic agent is

Accepted Answer

A) bleomycin. 
B) cisplatin. 
C) methotrexate. 
D) vincristine. 
A) bleomycin. 
B) cisplatin. 
C) methotrexate. 
D) vincristine.

Question 16

One major concern of the dental health care worker is thrombocytopenia in patients undergoing antineoplastic therapy because this can lead to an increased risk of infections.

Accepted Answer

A) Both parts of the statement are true. 
B) Both parts of the statement are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true. 
A) Both parts of the statement are true. 
B) Both parts of the statement are false. 
C) The first part of the statement is true;the second part is false. 
D) The first part of the statement is false;the second part is true.

Question 17

Which antineoplastic agent is used to manage breast cancer?

Accepted Answer

A) Plant alkaloid 
B) Antibiotic 
C) Steroid 
D) Estrogen 
E) Tamoxifen 
A) Plant alkaloid 
B) Antibiotic 
C) Steroid 
D) Estrogen 
E) Tamoxifen

Question 18

Antineoplastic agents will have the greatest negative effect on which of the following tissues?

Accepted Answer

A) Integumentary tissue 
B) Lungs,heart,and liver 
C) Gastrointestinal tract,bone marrow,and hair follicles 
D) Sensory tissue such as those for smell,sight,and hearing 
A) Integumentary tissue 
B) Lungs,heart,and liver 
C) Gastrointestinal tract,bone marrow,and hair follicles 
D) Sensory tissue such as those for smell,sight,and hearing

Question 19

Bisphosphonates work to reduce osteoporosis by

Accepted Answer

A) stimulating hemopoiesis. 
B) stimulating osteoblasts to produce new bone. 
C) binding to osteoclasts. 
D) remodeling cortical into cancellous bone. 
E) increasing blood flow within the osteon. 
A) stimulating hemopoiesis. 
B) stimulating osteoblasts to produce new bone. 
C) binding to osteoclasts. 
D) remodeling cortical into cancellous bone. 
E) increasing blood flow within the osteon.

Question 20

Each of the following normal tissues is especially susceptible to the actions of antineoplastic drugs except one.Which is the exception?

Accepted Answer

A) Hair follicles 
B) Bone marrow 
C) Liver 
D) Gastrointestinal tract 
A) Hair follicles 
B) Bone marrow 
C) Liver 
D) Gastrointestinal tract

Exam 20: Antineoplastic Drugs

Slowly growing cells are more susceptible to inhibition or destruction by antineoplastic agents.

Which of the following is a treatment option to alleviate symptoms of mucositis?

Dental procedures should be performed for a patient taking bisphosphonates

Antineoplastic agents may be used in the management of diseases with an inflammatory component.

Bisphosphonate-free holidays are not recommended before a dental procedure because these drugs stay in the bone for years.

Antineoplastic agents will affect bone marrow,leading to

Neurologic adverse effects are prevalent in all of the following antineoplastic agents except which one?

Each of the following will have the action prolonged and toxicity increased by allopurinol,which is used to prevent hyperuricemia,except one.Which is the exception?

Nausea and vomiting caused by antineoplastic agent therapy can be managed by administration of

Which folic acid analog antimetabolite antineoplastic drug is also used to treat rheumatoid arthritis?

_____ effects are associated primarily with administration or vincristine (Oncovin)or vinblastine (Velban).

Which of the following are symptoms of adverse reactions caused by bone marrow suppression: (1)susceptibility to infection, (2)bleeding, (3)high blood pressure, (4)fatigue?

The appointment should be scheduled _____ chemotherapy when providing oral care for patients on antineoplastic agents.

Antimetabolites such as methotrexate attack the cells at the S phase of the cell cycle because they interfere with purine and pyrimidine biosynthesis.

An example of a cell-cycle nonspecific antineoplastic agent is

One major concern of the dental health care worker is thrombocytopenia in patients undergoing antineoplastic therapy because this can lead to an increased risk of infections.

Which antineoplastic agent is used to manage breast cancer?

Antineoplastic agents will have the greatest negative effect on which of the following tissues?

Bisphosphonates work to reduce osteoporosis by

Each of the following normal tissues is especially susceptible to the actions of antineoplastic drugs except one.Which is the exception?

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