Question 1

Which antidepressant drug carries a "black box" warning regarding its potential to cause life-threatening liver failure?

Accepted Answer

A) Imipramine 
B) Bupropion 
C) Nefazodone 
D) Mirtazapine 
E) Venlafaxine 
A) Imipramine 
B) Bupropion 
C) Nefazodone 
D) Mirtazapine 
E) Venlafaxine C

Question 2

Interaction of monoamine oxidase inhibitors (MAOIs)with many drugs such as amphetamines,and with foods such as wines,cheese,and fish,can precipitate

Accepted Answer

A) hair loss. 
B) hypertensive crisis. 
C) gout. 
D) dysgeusia. 
A) hair loss. 
B) hypertensive crisis. 
C) gout. 
D) dysgeusia. B

Question 3

Which of the following are anticholinergic effects that may be associated with tricyclic antidepressants?

Accepted Answer

A) Xerostomia 
B) Bradycardia 
C) Urination 
D) Both A and B 
E) Both B and C 
A) Xerostomia 
B) Bradycardia 
C) Urination 
D) Both A and B 
E) Both B and C A

Question 4

Patients taking first-generation antipsychotics can experience severe intermittent temporomandibular joint (TMJ)pain.This pain is a consequence of

Accepted Answer

A) hyperalgesia produced by a-adrenergic blockade. 
B) anticholinergic side effects. 
C) dislocation of the mandible. 
D) extrapyramidal side effects. 
A) hyperalgesia produced by a-adrenergic blockade. 
B) anticholinergic side effects. 
C) dislocation of the mandible. 
D) extrapyramidal side effects.

Question 5

Which of the following types of dental medicaments must be administered with caution to patients taking tricyclic antidepressants?

Accepted Answer

A) Fluoride 
B) Antibiotics 
C) Anesthetics 
D) Analgesics 
A) Fluoride 
B) Antibiotics 
C) Anesthetics 
D) Analgesics

Question 6

First-generation antipsychotics are primarily _____ antagonists.

Accepted Answer

A) acetylcholine 
B) norepinephrine 
C) dopamine 
D) serotonin (5-hydroxytryptamine) 
A) acetylcholine 
B) norepinephrine 
C) dopamine 
D) serotonin (5-hydroxytryptamine)

Question 7

First-generation antipsychotic therapy must often be combined with _____ drugs such as benztropine to control excessive extrapyramidal stimulation.

Accepted Answer

A) adrenergic 
B) antiadrenergic 
C) cholinergic 
D) anticholinergic 
A) adrenergic 
B) antiadrenergic 
C) cholinergic 
D) anticholinergic

Question 8

Which works most quickly for a suicidal patient?

Accepted Answer

A) Bupropion 
B) Monoamine oxidase inhibitor 
C) Selective serotonin reuptake inhibitor 
D) Serotonin-norepinephrine reuptake inhibitor 
E) Electroconvulsive therapy (ECT) 
A) Bupropion 
B) Monoamine oxidase inhibitor 
C) Selective serotonin reuptake inhibitor 
D) Serotonin-norepinephrine reuptake inhibitor 
E) Electroconvulsive therapy (ECT)

Question 9

Which was the first selective serotonin reuptake inhibitor (SSRI)?

Accepted Answer

A) Sertraline (Zoloft) 
B) Fluoxetine (Prozac) 
C) Paroxetine (Paxil) 
D) Citalopram (Celexa) 
E) Escitalopram (Lexapro) 
A) Sertraline (Zoloft) 
B) Fluoxetine (Prozac) 
C) Paroxetine (Paxil) 
D) Citalopram (Celexa) 
E) Escitalopram (Lexapro)

Question 10

Abrupt withdrawal of serotonin-norepinephrine reuptake inhibitors (SNRIs)can lead to symptoms of

Accepted Answer

A) urinary retention. 
B) anxiety. 
C) tachycardia. 
D) sweating. 
A) urinary retention. 
B) anxiety. 
C) tachycardia. 
D) sweating.

Question 11

The chemoreceptor trigger zone (CTZ)is a site of action for prochlorperazine.

Accepted Answer

A) True 
 B)False

Question 12

Patients undergoing lithium therapy should be observed for signs of overdose toxicity,including

Accepted Answer

A) hyperpyrexia. 
B) constipation. 
C) muscle rigidity and fasciculations. 
D) loquacious speech. 
A) hyperpyrexia. 
B) constipation. 
C) muscle rigidity and fasciculations. 
D) loquacious speech.

Question 13

Which of the following antipsychotic agents have been approved for adjunctive treatment of major depressive disorder?

Accepted Answer

A) Low potency first-generation antipsychotics 
B) Medium potency first-generation antipsychotics 
C) High potency first-generation antipsychotics 
D) Second-generation antipsychotics. 
A) Low potency first-generation antipsychotics 
B) Medium potency first-generation antipsychotics 
C) High potency first-generation antipsychotics 
D) Second-generation antipsychotics.

Question 14

Bupropion is reserved for patients who are not responsive to other agents because of a potential for

Accepted Answer

A) cardiac arrhythmias. 
B) seizures. 
C) retinopathy. 
D) glaucoma. 
A) cardiac arrhythmias. 
B) seizures. 
C) retinopathy. 
D) glaucoma.

Question 15

Second-generation antipsychotics have fewer side effects than first-generation antipsychotics.

Accepted Answer

A) True 
 B)False

Question 16

Which of the following second-generation antipsychotics is associated with agranulocytosis?

Accepted Answer

A) Aripiprazole 
B) Clozapine 
C) Quetiapine 
D) Risperidone 
E) Ziprasidone 
A) Aripiprazole 
B) Clozapine 
C) Quetiapine 
D) Risperidone 
E) Ziprasidone

Question 17

In general,lower potency first-generation antipsychotic agents such as chlorpromazine (Thorazine)will have more of which of the following effects in contrast to the higher potency first-generation antipsychotic agents such as haloperidol (Haldol): (1)sedation, (2)orthostatic hypotension, (3)autonomic effects, (4)extrapyramidal effects?

Accepted Answer

A) 1,2,3,4 
B) 1,2,3 
C) 2,3,4 
D) 1,2 
E) 3,4 
A) 1,2,3,4 
B) 1,2,3 
C) 2,3,4 
D) 1,2 
E) 3,4

Question 18

Which of the following medications is used to treat bipolar depression?

Accepted Answer

A) Haloperidol 
B) Lithium 
C) Clozapine 
D) Paroxetine 
A) Haloperidol 
B) Lithium 
C) Clozapine 
D) Paroxetine

Question 19

Which antidepressant is least likely to cause xerostomia?

Accepted Answer

A) Bupropion 
B) Sertraline 
C) Chlorpromazine 
D) Amitriptyline 
E) Trazodone 
A) Bupropion 
B) Sertraline 
C) Chlorpromazine 
D) Amitriptyline 
E) Trazodone

Question 20

Which choice represents the current most commonly prescribed antidepressant agent?

Accepted Answer

A) Monoamine oxidase inhibitor (MAOI) 
B) Tricyclic antidepressant (TC
A)  
C) Selective serotonin uptake inhibitor (SSRI) 
D) Second-generation antipsychotic 
A) Monoamine oxidase inhibitor (MAOI) 
B) Tricyclic antidepressant (TC
A)  
C) Selective serotonin uptake inhibitor (SSRI) 
D) Second-generation antipsychotic

Exam 15: Drugs for the Treatment of Central Nervous System Disorders

Which antidepressant drug carries a "black box" warning regarding its potential to cause life-threatening liver failure?

Interaction of monoamine oxidase inhibitors (MAOIs)with many drugs such as amphetamines,and with foods such as wines,cheese,and fish,can precipitate

Which of the following are anticholinergic effects that may be associated with tricyclic antidepressants?

Patients taking first-generation antipsychotics can experience severe intermittent temporomandibular joint (TMJ)pain.This pain is a consequence of

Which of the following types of dental medicaments must be administered with caution to patients taking tricyclic antidepressants?

First-generation antipsychotics are primarily _____ antagonists.

First-generation antipsychotic therapy must often be combined with _____ drugs such as benztropine to control excessive extrapyramidal stimulation.

Which works most quickly for a suicidal patient?

Which was the first selective serotonin reuptake inhibitor (SSRI)?

Abrupt withdrawal of serotonin-norepinephrine reuptake inhibitors (SNRIs)can lead to symptoms of

The chemoreceptor trigger zone (CTZ)is a site of action for prochlorperazine.

Patients undergoing lithium therapy should be observed for signs of overdose toxicity,including

Which of the following antipsychotic agents have been approved for adjunctive treatment of major depressive disorder?

Bupropion is reserved for patients who are not responsive to other agents because of a potential for

Second-generation antipsychotics have fewer side effects than first-generation antipsychotics.

Which of the following second-generation antipsychotics is associated with agranulocytosis?

Which of the following medications is used to treat bipolar depression?

Which antidepressant is least likely to cause xerostomia?

Which choice represents the current most commonly prescribed antidepressant agent?

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